lncBodyMap

To functionally characterize the lncRNAs integrated from various resources, we have performed gene expression quantification, weighted gene co-expression network analysis (WGCNA), expression quantitative trail loci (eQTL), and summary mendelian randomization (SMR) using the GTEx data from 30 tissues and UK biobank data. Shown below is a cartoon for the human body and the list of tissues for which the above-listed information is available.

 

Adipose Tissue Adrenal Gland Bladder Blood Blood Vessel Bone Marrow Brain Breast Cervix Uteri Colon Esophagus Heart Kidney Liver Lung Muscle Nerve Ovary Pancreas Pituitary Prostate Salivary Gland Skin Small Intestine Spleen Stomach Testis Thyroid Uterus Vagina

Summary Table

 

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Tissue RNA seq samples with WGS SNPs (MAF>0.05) Genes lncRNAs eQTLs eQTL perm p < 0.05
Adipose_Tissue 363 5,952,169 27,029 11,854 54,871,184 5,766
Adrenal_Gland 146 5,886,806 25,943 10,970 51,879,876 4,077
Bladder 9 5,462,615 28,695 13,098 * *
Blood 356 5,953,536 18,412 6,624 37,414,178 2,877
Blood_Vessel 378 5,963,536 25,614 10,844 51,947,442 5,854
Bone_Marrow 91 * 12,612 9,959 * *
Brain 170 5,857,467 31,339 15,191 62,844,553 3,488
Breast 184 5,901,708 28,839 13,159 58,130,064 4,267
Cervix_Uteri 8 5,522,234 28,706 13,057 * *
Colon 250 5,907,992 28,297 12,516 57,063,773 4,767
Esophagus 353 5,941,386 26,803 11,364 54,314,052 *
Fallopian_Tube 7 * 16,552 1,940 * 4,815
Heart 251 5,913,705 24,959 10,171 50,153,256 4,375
Kidney 29 5,742,588 28,917 13,191 * *
Liver 118 5,871,833 23,846 9,642 47,689,780 2,759
Lung 274 5,926,605 29,045 13,301 58,884,074 5,461
Muscle 359 5,962,131 22,042 8,484 44,548,539 4,454
Nerve 268 5,941,274 29,326 13,854 59,363,204 7,416
Ovary 99 5,873,449 27,292 12,447 54,588,663 3,466
Pancreas 167 5,905,087 23,569 9,359 47,408,959 *
Pituitary 108 5,814,865 30,586 14,738 60,707,019 3,949
Prostate 101 5,810,666 30,373 14,442 60,377,553 *
Salivary_Gland 63 5,771,591 28,409 12,730 * *
Skin 442 5,966,760 27,316 11,874 55,698,051 6,210
Small_Intestine 90 5,777,092 30,046 14,096 59,426,622 2,987
Spleen 108 5,874,443 28,284 13,315 56,914,604 4,743
Stomach 182 5,890,077 26,974 11,444 54,242,450 3,804
Testis 171 5,875,543 47,909 30,132 98,376,057 8,951
Thyroid 286 5,941,584 29,715 14,111 60,217,108 7,611
Uterus 82 5,795,583 28,175 13,009 55,748,102 3,037
Vagina 87 5,837,620 28,423 12,794 56,861,978 2,865

 

 * :No data due to small sample size or lack of genotype data

 Required sample size is 80 for eQTL and 20 for WGCNA.

 No Genotype data for Bone Marrow tissue