Metamoodics Gene Information


  Chromosome: chr17    Cytoband: q23.3    Gene: ACE


BP - Candidate Gene Association Studies for ACE



Shown here are all published candidate gene association studies of gene ACE in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityidid
rs4340 [0.77,1.2]0.960.114-0.3590.1434971351
Arinami,1995 [1.01,2.85]1.70.2642.0131.35531459Japanese0.5300.4700.6600.340
Furlong,2000 [0.67,1.16]0.880.141-0.9070.438157313Caucasian0.4430.5570.4740.526
Meira-Lima,2000 [0.78,1.43]1.060.1530.3810.153115323Caucasian0.4500.5500.4400.560
Pauls,2000 [0.58,1.16]0.820.177-1.1210.581106169Caucasian0.5520.4480.5030.497
Segman,2002 [0.48,1.16]0.750.223-1.2930.7088887Caucasian0.6800.3200.6100.390






Author Title    Journal Year PMID
Meira-Lima,et al.  Angiotensinogen and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humans.  Neurosci. Lett.  2000  11027844 
Furlong,et al.  No association of an insertion/deletion polymorphism in the angiotensin I converting enzyme gene with bipolar or unipolar affective disorders.  Am. J. Med. Genet.  2000  11121171 
Pauls,et al.  Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder.  J Neural Transm  2000  11145009 
Segman,et al.  Angiotensin converting enzyme gene insertion/deletion polymorphism: case-control association studies in schizophrenia, major affective disorder, and tardive dyskinesia and a family-based association study in schizophrenia.  Am. J. Med. Genet.  2002  11920854 
Arinami,et al.  An insertion/deletion polymorphism in the angiotensin converting enzyme gene is associated with both brain substance P contents and affective disorders.  Biol. Psychiatry  1996  8931914