Metamoodics Gene Information


  Chromosome: chr11    Cytoband: p14.1    Gene: BDNF


BP - Candidate Gene Association Studies for BDNF



Shown here are all published candidate gene association studies of gene BDNF in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityCTCT
rs6265 [0.87,1]0.930.037-1.9600.050038976807
Nakata,2003 [0.71,1.35]0.980.163-0.1240.9016130190Asian0.5850.4150.5790.421
Hong,2003 [0.66,1.21]0.890.157-0.7440.4571108392Asian0.5460.4540.5180.482
Oswald,2004 [0.74,1.69]1.120.2100.5400.5893108158Caucasian0.7690.2310.7880.212
Kunugi,2004 [0.86,1.21]1.020.0870.2270.8203519588Asian0.5920.4080.5970.403
Skibinska,2004 [0.67,1.16]0.880.141-0.9070.3644352375Caucasian0.8350.1650.8170.183
Schumacher,2005 [0.79,1.27]10.1220.0001.00002811097Caucasian0.8100.1900.8100.190
Lohoff,2005 [0.68,0.98]0.820.091-2.1820.0291621998Caucasian0.8210.1790.7900.210
Green,2006 [0.82,1.08]0.940.071-0.8740.38249622100Caucasian0.8200.1800.8100.190
Tramontia,2007 [0.81,2.03]1.290.2311.1010.2710114137Caucasian0.8030.1970.8390.161
Kim,2008 [0.71,1.23]0.940.137-0.4510.6520169251Asian0.5500.4500.5340.466
Vincze,2008 [0.63,1.06]0.810.137-1.5350.1247336313Caucasian0.7920.2080.7560.244
Tang,2008 [0.64,1.13]0.850.145-1.1190.2633197208Asian0.6040.3960.5650.435






Author Title    Journal Year PMID
Sklar,et al.  Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.  Mol. Psychiatry  2002  12140781 
Neves-Pereira,et al.  The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.  Am. J. Hum. Genet.  2002  12161822 
Nakata,et al.  Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder.  Neurosci. Lett.  2003  12524161 
Hong,et al.  Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior.  Neuropsychobiology  2003  14673216 
Oswald,et al.  Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2004  15274036 
Kunugi,et al.  No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study.  Biol. Psychiatry  2004  15336520 
Skibinska,et al.  Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.  World J. Biol. Psychiatry  2004  15543516 
Schumacher,et al.  Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.  Biol. Psychiatry  2005  16005437 
Lohoff,et al.  Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2005  16152572 
Green,et al.  Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK.  Br J Psychiatry  2006  16388065 
Kremeyer,et al.  Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2006  16741941 
Müller,et al.  Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: family-based association study.  Br J Psychiatry  2006  17012654 
Tramontina,et al.  Val66met polymorphism and serum brain-derived neurotrophic factor levels in bipolar disorder.  Mol. Psychiatry  2007  17325716 
Mick,et al.  Family and genetic association studies of bipolar disorder in children.  Child Adolesc Psychiatr Clin N Am  2009  19264272 
Kim,et al.  Brain-derived neurotrophic factor Val/Met polymorphism and bipolar disorder. Association of the Met allele with suicidal behavior of bipolar patients.  Neuropsychobiology  2008  18843195 
Vincze,et al.  Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene.  Bipolar Disord  2008  18657242 
Fan,et al.  Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism.  Novartis Found. Symp.  2008  18497095 
Tang,et al.  Association of the brain-derived neurotrophic factor gene and bipolar disorder with early age of onset in mainland China.  Neurosci. Lett.  2008  18242852