Metamoodics Gene Information


  Chromosome: chr22    Cytoband: q11.21    Gene: COMT


BP - Candidate Gene Association Studies for COMT



Shown here are all published candidate gene association studies of gene COMT in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityAGAG
rs165599 [0.8,1.55]1.110.1700.6130.54015506703
Shifman,2004 [0.63,0.93]0.770.096-2.7130.00672175952caucasian0.5600.4400.6200.380
Funke,2005 [0.97,1.91]1.360.1731.7750.076082467caucasian0.6050.3950.6740.326
Prata,2006 [0.8,1.46]1.080.1540.5000.6168199182caucasian0.6580.3420.6400.360
Burdick,2007 [0.97,2.56]1.580.2461.8580.063252102caucasian0.5480.4520.6570.343
rs4680 [0.88,1.15]1.010.0660.1500.880628897086
Gutierrez,1997 [0.68,1.5]1.010.2020.0490.960788113caucasian0.5700.4300.5700.430
Kunugi,1997 [0.64,1.34]0.920.192-0.4350.6639107121caucasian0.5300.4700.5100.490
Lachman,1997 [0.6,1.53]0.960.238-0.1720.86376387caucasian0.6000.4000.6000.400
BIOMED,1997 [0.75,1.11]0.910.101-0.9300.3521412368caucasian0.5000.5000.5200.480
Li,1997 [0.3,0.8]0.490.250-2.8520.00439398asian0.6900.3100.8200.180
Kirov,1998 [0.68,1.25]0.920.156-0.5330.5939165161caucasian0.5300.4700.5100.490
Ohara,1998 [0.6,1.7]1.010.2660.0370.970140135asian0.6500.3500.6500.350
Mynett-Johnson,1998 [1.04,2]1.450.1642.2650.0235147147caucasian0.5600.4400.4700.530
Rotondo,2002 [0.4,0.83]0.570.192-2.9320.0034111127caucasian0.5300.4700.3900.610
Shifman,2004 [0.73,1.08]0.880.104-1.2230.22122144018caucasian0.5500.4500.5200.480
Funke,2005 [0.99,1.92]1.380.1681.9120.055982467caucasian0.5570.4430.4750.525
Prata,2006 [0.88,1.53]1.160.1411.0510.2934209193caucasian0.5220.4780.4840.516
Bogaert,2006 [0.73,1.21]0.940.129-0.4800.6310182364caucasian0.5590.4410.5420.458
Serretti,2006 [0.86,1.54]1.150.1490.9380.3482446116caucasian0.5560.4440.5910.409
Burdick,2007 [0.8,2.07]1.290.2411.0550.291252102caucasian0.5480.4520.4850.515
Zhang,2009 [1.16,1.74]1.420.1043.3820.0007478469asian0.6860.3140.7570.243
rs737865 [0.81,1.08]0.930.076-0.9510.34155474651
Shifman,2004 [0.71,1.05]0.860.102-1.4810.13862143894caucasian0.5600.4400.5900.410
Funke,2005 [0.77,1.56]1.100.1780.5350.592982467caucasian0.6730.3270.6910.309
Prata,2006 [0.72,1.34]0.980.160-0.1270.8993199188caucasian0.7090.2910.7130.287
Burdick,2007 [0.6,1.64]0.990.258-0.0390.968952102caucasian0.6730.3270.6720.328






Author Title    Journal Year PMID
Gutiérrez,et al.  Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.  Am J Psychiatry  1997  8988970 
Lachman,et al.  Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder.  Psychiatr. Genet.  1997  9264133 
Kunugi,et al.  No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene.  Biol. Psychiatry  1997  9270905 
,et al.  No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group.  Br J Psychiatry  1997  9330018 
Li,et al.  Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder.  Pharmacogenetics  1997  9352569 
Ohara,et al.  Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.  Neuroreport  1998  9631418 
Mynett-Johnson,et al.  Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.  Psychiatr. Genet.  1998  9861640 
Rotondo,et al.  Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder.  Am J Psychiatry  2002  11772685 
Sklar,et al.  Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.  Mol. Psychiatry  2002  12140781 
Shifman,et al.  COMT: a common susceptibility gene in bipolar disorder and schizophrenia.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2004  15211633 
Funke,et al.  COMT genetic variation confers risk for psychotic and affective disorders: a case control study.  Behav Brain Funct  2005  16232322 
Fallin,et al.  Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.  Am. J. Hum. Genet.  2005  16380905 
Szöke,et al.  Lack of influence of COMT and NET genes variants on executive functions in schizophrenic and bipolar patients, their first-degree relatives and controls.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2006  16741933 
Serretti,et al.  Catechol-O-methyltransferase gene variants in mood disorders in the Italian population.  Psychiatr. Genet.  2006  16969269 
Van Den Bogaert,et al.  No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.  Psychiatr. Genet.  2006  16969276 
Prata,et al.  Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes.  Psychiatr. Genet.  2006  17106420 
Burdick,et al.  COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance.  Bipolar Disord  2007  17547583 
Zhang,et al.  The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis.  J Neural Transm  2009  19578924