Metamoodics Gene Information


  Chromosome: chr13    Cytoband: q33.2    Gene: DAOA


BP - Candidate Gene Association Studies for DAOA



Shown here are all published candidate gene association studies of gene DAOA in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityATAT
rs1421292 [0.95,1.18]1.060.0551.0650.286913002027
Schumacher,2004 [0.97,1.53]1.220.1161.7210.0852300300caucasian0.4500.5500.5000.500
Schulze,2005 [0.77,1.2]0.960.114-0.3590.7199294311caucasian0.4800.5200.4900.510
Williams,2006 [0.92,1.18]1.040.0640.6090.54277061416caucasian0.4800.5200.4900.510
rs2391191 [0.85,1.16]0.990.081-0.1240.901115562409
Chen,2004 [0.57,1.16]0.810.183-1.1500.2501139113caucasian0.6300.3700.5800.420
Schumacher,2004 [0.9,1.44]1.140.1191.0990.2716300300caucasian0.6100.3900.6400.360
Williams,2006 [0.78,1.01]0.890.065-1.8060.07097061416caucasian0.6310.3690.6030.397
Zhang,2009 [0.93,1.34]1.120.0921.2390.2155411580asian0.6080.3920.5810.419
rs3918342 [1.01,1.3]1.140.0671.9550.050510511197
Schumacher,2004 [1.06,1.66]1.320.1172.3740.0176300300caucasian0.4700.5300.5400.460
Schulze,2005 [0.86,1.36]1.080.1180.6540.5129294311caucasian0.5100.4900.5300.470
Zhang,2009 [0.91,1.29]1.080.0910.8490.3959457586asian0.5360.4640.5160.484
rs778294 [0.74,1.13]0.910.110-0.8540.393314652302
Schumacher,2004 [0.68,1.11]0.870.124-1.1200.2625300300caucasian0.7200.2800.6900.310
Williams,2006 [0.93,1.24]1.070.0750.8990.36857061416caucasian0.6980.3020.7130.287
Zhang,2009 [0.59,1]0.770.133-1.9600.0500459586asian0.1100.8900.1390.861






Author Title    Journal Year PMID
Hattori,et al.  Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series.  Am. J. Hum. Genet.  2003  12647258 
Chen,et al.  Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33.  Mol. Psychiatry  2004  14699445 
Schumacher,et al.  Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder.  Mol. Psychiatry  2004  14966479 
Schulze,et al.  Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes.  Am J Psychiatry  2005  16263850 
Fallin,et al.  Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.  Am. J. Hum. Genet.  2005  16380905 
Williams,et al.  Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.  Arch. Gen. Psychiatry  2006  16585465 
Zhang,et al.  First evidence of association between G72 and bipolar disorder in the Chinese Han population.  Psychiatr. Genet.  2009  19339914 
Soronen,et al.  Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample.  Biol. Psychiatry  2008  18466879 
Prata,et al.  Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2008  18165970 
Shi,et al.  Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis.  Schizophr. Res.  2008  18023149