Metamoodics Gene Information


  Chromosome: chr11    Cytoband: q23.1-q23.2    Gene: DRD2


BP - Candidate Gene Association Studies for DRD2



Shown here are all published candidate gene association studies of gene DRD2 in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityC-C-
rs1799732 [0.87,1.44]1.120.1280.8840.4248151257
Stober,1998 [0.32,1.36]0.660.369-1.1260.58570290Caucasian0.9360.0640.9050.095
Furlong,1998 [0.76,1.93]1.210.2380.8000.373131262Caucasian0.8780.1220.8970.103
Li,1999 [1.04,2.98]1.760.2692.1041.451118196Asian0.8700.1300.9200.080
Li,1999 [0.57,1.67]0.970.277-0.1100.040157143Caucasian0.9000.1000.9000.100
Leszczynska-Rodziewicz,2005 [0.76,1.48]1.060.1700.3420.135339366Caucasian0.8880.1120.8930.107
rs1800497 [0.78,1.85]1.200.2210.8260.388328501
Savoye,1998 [0.47,1.58]0.860.310-0.4860.20350162Caucasian0.8400.1600.8200.180
Li,1999 [1.24,2.48]1.750.1783.1462.781121196Asian0.6200.3800.7400.260
Li,1999 [0.7,1.48]1.020.1900.1040.038157143Caucasian0.7200.2800.7300.270
rs1801028 [0.59,1.74]1.010.2780.0360.013396695
Craddock,1995 [0.16,19.68]1.771.2290.4650.1928272Caucasian0.9880.0120.9930.007
Sasaki,1996 [0.3,4.03]1.110.6580.1590.05963255Caucasian0.9760.0240.9780.022
Manaki,1996 [0.71,8.02]2.390.6181.4110.80052100Asian0.9420.0580.9750.025
Li,1999 [0.35,1.89]0.810.432-0.4870.20397189Asian0.9600.0400.9500.050
Heiden,2000 [0.14,1.83]0.510.652-1.0330.52110279Caucasian0.9800.0200.9600.040






Author Title    Journal Year PMID
Stöber,et al.  Insertion/deletion variant (-141C Ins/Del) in the 5' regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder. Short communication.  J Neural Transm  1998  9588764 
Furlong,et al.  No association of a functional polymorphism in the dopamine D2 receptor promoter region with bipolar or unipolar affective disorders.  Am. J. Med. Genet.  1998  9754623 
Savoye,et al.  No association between dopamine D1, D2, and D3 receptor genes and manic-depressive illness.  Biol. Psychiatry  1998  9787891 
Li,et al.  Association analysis between dopamine receptor genes and bipolar affective disorder.  Psychiatry Res  1999  10482338 
Bocchetta,et al.  Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia.  Am. J. Med. Genet.  1999  10490710 
Kirov,et al.  Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5.  Mol. Psychiatry  1999  10578238 
Gorwood,et al.  The DRD2 gene and the risk for alcohol dependence in bipolar patients.  Eur. Psychiatry  2000  10881206 
Heiden,et al.  Association studies of candidate genes in bipolar disorders.  Neuropsychobiology  2000  11093065 
Massat,et al.  Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders.  Am. J. Med. Genet.  2002  11857579 
Sklar,et al.  Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.  Mol. Psychiatry  2002  12140781 
Leszczyńska-Rodziewicz,et al.  Lack of association between polymorphisms of dopamine receptors, type D2, and bipolar affective illness in a Polish population.  Med. Sci. Monit.  2005  15917720 
Fallin,et al.  Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.  Am. J. Hum. Genet.  2005  16380905 
Nöthen,et al.  Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder.  Am J Psychiatry  1992  1346486 
Craddock,et al.  Association study of bipolar disorder using a functional polymorphism (Ser311-->Cys) in the dopamine D2 receptor gene.  Psychiatr. Genet.  1995  7551964 
Pérez de Castro,et al.  A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.  J. Med. Genet.  1995  7760324 
Arinami,et al.  Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorders.  Am. J. Med. Genet.  1996  8723039 
Sasaki,et al.  No evidence for association of dopamine D2 receptor variant (Ser311/Cys311) with major psychosis.  Am. J. Med. Genet.  1996  8837713 
Manki,et al.  Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders.  J Affect Disord  1996  8882909 
Souery,et al.  Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes.  Am. J. Med. Genet.  1996  8950413