Metamoodics Gene Information


  Chromosome: chr3    Cytoband: q13.31    Gene: DRD3


BP - Candidate Gene Association Studies for DRD3



Shown here are all published candidate gene association studies of gene DRD3 in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityTCTC
rs6280 [0.91,1.12]1.010.0530.1890.850415311837
Shaikh,1993 [0.47,1.19]0.750.236-1.2210.22197576Caucasian0.6600.3400.5920.408
Rietschel,1993 [0.7,1.71]1.090.2300.3750.707683100Caucasian0.6810.3190.7000.300
Manki,1996 [0.53,1.53]0.90.271-0.3890.697152100Asian0.7310.2690.7100.290
Souery,1996 [0.82,2.41]1.410.2731.2560.20906262Caucasian0.6530.3470.7260.274
Gomez-Casero,1996 [0.45,1.46]0.810.301-0.7010.48335153Caucasian0.7060.2940.6600.340
Savoye,1998 [0.56,1.51]0.920.253-0.3300.74156186Caucasian0.6800.3200.6630.337
Li,1999 [0.55,1.25]0.830.209-0.8920.3725109115Asian0.7390.2610.7000.300
Chiaroni,2000 [0.61,1.99]1.10.3020.3150.75276060Caucasian0.4500.3080.4670.292
Heiden,2000 [0.65,1.59]1.020.2260.0870.930310279Caucasian0.6860.3140.6900.310
Elvidge,2001 [0.78,1.35]1.020.1430.1380.8899229225Caucasian0.6680.3320.6730.327
Monit,2005 [0.77,1.23]0.970.121-0.2510.8015339366Caucasian0.7180.2820.7130.287
Bogaert,2006 [0.84,1.41]1.090.1310.6560.5117182364Caucasian0.6370.3630.6560.344
Parsian,1995 [0.89,2.35]1.440.2501.4590.14456691Caucasian0.6590.3410.7360.264
Chiaroni,2000 [0.63,1.98]1.120.2910.3900.69666060Caucasian0.3580.4420.3330.458






Author Title    Journal Year PMID
Piccardi,et al.  No evidence of association between dopamine D3 receptor gene and bipolar affective disorder.  Am. J. Med. Genet.  1997  9129711 
Savoye,et al.  No association between dopamine D1, D2, and D3 receptor genes and manic-depressive illness.  Biol. Psychiatry  1998  9787891 
Li,et al.  Association analysis between dopamine receptor genes and bipolar affective disorder.  Psychiatry Res  1999  10482338 
Kirov,et al.  Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5.  Mol. Psychiatry  1999  10578238 
Chiaroni,et al.  Possible involvement of the dopamine D3 receptor locus in subtypes of bipolar affective disorder.  Psychiatr. Genet.  2000  10909128 
Heiden,et al.  Association studies of candidate genes in bipolar disorders.  Neuropsychobiology  2000  11093065 
Elvidge,et al.  Allelic variation of a BalI polymorphism in the DRD3 gene does not influence susceptibility to bipolar disorder: results of analysis and meta-analysis.  Am. J. Med. Genet.  2001  11378841 
Massat,et al.  Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders.  Am. J. Med. Genet.  2002  11857579 
Sklar,et al.  Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.  Mol. Psychiatry  2002  12140781 
Leszczyńska-Rodziewicz,et al.  Lack of association between polymorphisms of dopamine receptors, type D2, and bipolar affective illness in a Polish population.  Med. Sci. Monit.  2005  15917720 
Fallin,et al.  Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.  Am. J. Hum. Genet.  2005  16380905 
Van Den Bogaert,et al.  No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.  Psychiatr. Genet.  2006  16969276 
Parsian,et al.  Possible association between the dopamine D3 receptor gene and bipolar affective disorder.  Am. J. Med. Genet.  1995  7573178 
Shaikh,et al.  The dopamine D3 receptor gene: no association with bipolar affective disorder.  J. Med. Genet.  1993  8098068 
Rietschel,et al.  A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.  Psychiatry Res  1993  8493294 
Manki,et al.  Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders.  J Affect Disord  1996  8882909 
Souery,et al.  Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes.  Am. J. Med. Genet.  1996  8950413 
Gómez-Casero,et al.  No association between particular DRD3 and DAT gene polymorphisms and manic-depressive illness in a Spanish sample.  Psychiatr. Genet.  1996  9149327