Metamoodics Gene Information


  Chromosome: chr11    Cytoband: p15.5    Gene: DRD4


BP - Candidate Gene Association Studies for DRD4



Shown here are all published candidate gene association studies of gene DRD4 in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicity
exonIII-repeat(4/2) [1.01,1.59]1.270.1152.0851.431596986
Lim,1994 [0.53,1.64]0.940.284-0.2180.082147150caucasian0.6360.0920.8950.060
Manki,1996 [0.63,3.8]1.540.4610.9370.45752100asian0.8370.0870.8950.060
Oruc,1997 [0.39,2.89]1.060.5120.1140.0413965caucasian0.6800.0900.6800.080
Li,1999 [0.74,1.91]1.190.2410.7210.32784154asian0.7560.2080.7700.179
Serretti,1999 [1.12,2.23]1.580.1762.6022.033210471caucasian0.6500.1500.7000.100
Castro,1999 [0.36,1.94]0.840.427-0.4080.1666446caucasian0.6600.1100.6600.130
exonIII-repeat(4/3) [0.5,1.57]0.890.290-0.4020.163544886
Lim,1994 [0.26,1.14]0.550.372-1.6080.967147150caucasian0.6360.0410.6270.073
Oruc,1997 [0.27,5.78]1.250.7810.2860.1113965caucasian0.6800.0400.6800.030
Li,1999 [0.14,3.9]0.750.841-0.3420.13584154asian0.7560.0120.7700.016
Serretti,1999 [0.88,3.4]1.730.3451.5900.951210471caucasian0.6500.0400.7000.030
Castro,1999 [0.18,1.63]0.540.564-1.0930.5626446caucasian0.6600.0500.6600.090
exonIII-repeat(4/5) [0.89,2.92]1.610.3041.5680.932532940
Lim,1994 [0.39,7.11]1.680.7360.7050.318147150caucasian0.6360.0170.6270.010
Manki,1996 [0.7,6.05]2.060.5501.3150.72552100asian0.8370.0670.8950.035
Oruc,1997 [0.06,5.46]0.551.171-0.5110.2153965caucasian0.6800.0100.6800.020
Li,1999 [0.14,3.9]0.750.841-0.3420.13584154asian0.7560.0120.7700.016
Serretti,1999 [0.76,5.89]2.110.5241.4260.813210471caucasian0.6500.0200.7000.010
exonIII-repeat(4/7) [0.83,1.33]1.050.1210.4050.164460732
Lim,1994 [0.14,7.21]1.011.0030.0100.003147150caucasian0.6360.0070.6270.006
Li,1999 [0.04,2.61]0.311.087-1.0770.55184154asian0.7560.0060.7700.020
Serretti,1999 [0.14,3.35]0.690.806-0.4600.190210471caucasian0.6500.0000.7000.010
exonIII-repeat(4/6) [0.22,1.83]0.630.544-0.8490.403441775
Lim,1994 [0.72,1.66]1.10.2100.4540.187147150caucasian0.6360.2070.6270.187
Oruc,1997 [0.35,1.81]0.790.423-0.5570.2393965caucasian0.6800.1300.6800.170
Serretti,1999 [0.73,1.41]1.010.1700.0580.021210471caucasian0.6500.1400.7000.150
Castro,1999 [0.63,3.28]1.440.4200.8680.4146446caucasian0.6600.1600.6600.110






Author Title    Journal Year PMID
Oruc,et al.  Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients.  Am. J. Med. Genet.  1997  9129719 
Li,et al.  Association analysis between dopamine receptor genes and bipolar affective disorder.  Psychiatry Res  1999  10482338 
Serretti,et al.  Dopamine receptor D4 gene is not associated with major psychoses.  Am. J. Med. Genet.  1999  10490704 
Bocchetta,et al.  Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia.  Am. J. Med. Genet.  1999  10490710 
Serretti,et al.  DRD4 exon 3 variants associated with delusional symptomatology in major psychoses: a study on 2,011 affected subjects.  Am. J. Med. Genet.  2001  11353451 
Serretti,et al.  Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders.  Am. J. Med. Genet.  2002  11992558 
Muglia,et al.  Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4.  Mol. Psychiatry  2002  12232779 
Chotai,et al.  Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms.  Psychiatry Res  2003  12860364 
Leszczyńska-Rodziewicz,et al.  Lack of association between polymorphisms of dopamine receptors, type D2, and bipolar affective illness in a Polish population.  Med. Sci. Monit.  2005  15917720 
Fallin,et al.  Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.  Am. J. Hum. Genet.  2005  16380905 
Aguirre,et al.  Association analysis of exon III and exon I polymorphisms of the dopamine D4 receptor locus in Mexican psychotic patients.  Psychiatry Res  2007  17822780 
Lim,et al.  No evidence of association between dopamine D4 receptor variants and bipolar affective disorder.  Am. J. Med. Genet.  1994  7810585 
Pérez de Castro,et al.  No association between dopamine D4 receptor polymorphism and manic depressive illness.  J. Med. Genet.  1994  7853381 
Manki,et al.  Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders.  J Affect Disord  1996  8882909 
Di Bella,et al.  Association study of a null mutation in the dopamine D4 receptor gene in Italian patients with obsessive-compulsive disorder, bipolar mood disorder and schizophrenia.  Psychiatr. Genet.  1996  8902887