Metamoodics Gene Information


  Chromosome: chr12    Cytoband: p13.31    Gene: GNB3


BP - Candidate Gene Association Studies for GNB3



Shown here are all published candidate gene association studies of gene GNB3 in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityCTCT
rs5443 [0.68,1.8]1.10.2510.3790.7044282346
Zill,2000 [1.02,6.48]2.570.4722.0000.045510111caucasian0.5000.5000.7200.280
Corson,2001 [0.55,1.68]0.960.286-0.1430.886310837caucasian0.6710.3290.6620.338
Kunugi,2002 [0.65,1.17]0.870.151-0.9210.3569164198asian0.4910.5090.5250.475






Author Title    Journal Year PMID
Zill,et al.  Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment.  Neuroreport  2000  10884039 
Lin,et al.  Association analysis of a functional G protein beta3 subunit gene polymorphism (C825T) in mood disorders.  Neuropsychobiology  2001  11586049 
Kunugi,et al.  Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders.  J Neural Transm  2002  12075862 
Willeit,et al.  C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder.  Biol. Psychiatry  2003  14512207 
Johansson,et al.  Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism.  Biol. Psychiatry  2004  14744475 
Corson,et al.  Association analysis of G-protein beta 3 subunit gene with altered Ca(2+) homeostasis in bipolar disorder.  Mol. Psychiatry  2001  11317211