Metamoodics Gene Information


  Chromosome: chr3    Cytoband: q13.33    Gene: GSK3B


BP - Candidate Gene Association Studies for GSK3B



Shown here are all published candidate gene association studies of gene GSK3B in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityAGAG
rs334558 [0.84,1.09]0.960.065-0.6300.2779951515
Lee,2006 [0.66,1.2]0.890.152-0.7640.352120350asian0.610.390.580.42
Nishiguchi,2006 [0.75,1.18]0.940.116-0.5330.226280407caucasian0.650.350.640.36
Szczepankiewicz,2006 [0.9,1.35]1.110.1001.0450.529416408caucasian0.6230.3770.6460.354
Scassellati,2007 [0.63,1.07]0.830.130-1.4380.823179350caucasian0.6480.3520.6030.397
rs3755557 [0.78,1.17]0.960.101-0.4040.1645791107
Lee,2006 [0.61,1.32]0.900.195-0.5390.229120350asian0.180.820.170.83
Nishiguchi,2006 [0.64,1.22]0.890.161-0.7240.329280407caucasian0.130.880.140.86
Scassellati,2008 [0.78,1.6]1.120.1820.6230.273179350caucasian0.1430.8570.1570.843






Author Title    Journal Year PMID
Benedetti,et al.  A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder.  Neurosci. Lett.  2004  14729229 
Nishiguchi,et al.  Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder.  Neurosci. Lett.  2006  16289783 
Lee,et al.  No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population.  Neurosci. Lett.  2006  16289845 
Szczepankiewicz,et al.  Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder.  Neuropsychobiology  2006  16397405 
Nievergelt,et al.  Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2006  16528748 
Lachman,et al.  Increase in GSK3beta gene copy number variation in bipolar disorder.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2007  17357145