Metamoodics Gene Information


  Chromosome: chr13    Cytoband: q14.2    Gene: HTR2A


BP - Candidate Gene Association Studies for HTR2A



Shown here are all published candidate gene association studies of gene HTR2A in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityGTGT
rs1805055 [0.32,2.47]0.900.515-0.2050.8379486618
Maria,1997 [0.81,3.4]1.660.3661.3860.1659305413caucasian0.9700.0300.9800.020
Gutierrez,1997 [0.12,3.52]0.640.870-0.5130.607988113caucasian0.9890.0110.9820.018
Ranade,2003 [0.06,1.74]0.330.848-1.3070.19129392caucasian0.9900.0100.9700.030
rs2070040 [0.76,1.16]0.940.107-0.5770.56419551474
Johansson,2001 [0.61,1.47]0.950.223-0.2300.81798282caucasian0.5730.4270.5610.439
Chee,2001 [0.46,0.88]0.640.162-2.7470.0060142148asian0.5920.4080.4800.520
Bonnier,2002 [1.05,2.09]1.480.1762.2260.0260127142caucasian0.5390.4610.6340.366
Ranade,2003 [0.56,1.28]0.850.209-0.7780.43659392caucasian0.6100.3900.5700.430
Etain,2004 [0.81,1.32]1.030.1270.2340.8153356208caucasian0.5420.4580.5500.450
Kishi,2009 [0.68,1.11]0.870.124-1.1200.2625155802asian0.5940.4060.5600.440
rs6305 [0.45,2.84]1.140.4660.2810.7784480617
Maria,1997 [0.95,3.45]1.810.3291.8030.0714299412caucasian0.9600.0400.9800.020
Gutierrez,1997 [0.12,1.19]0.380.582-1.6610.096688113caucasian0.9770.0230.9420.058
Ranade,2003 [0.58,4.98]1.700.5480.9680.33329392caucasian0.9500.0500.9700.030
rs6313 [0.88,1.08]0.980.050-0.4080.683613732386
Zhang,1997 [0.41,1.25]0.710.289-1.1870.235331150asian0.6130.3870.5300.470
Maria,1997 [0.68,1.04]0.840.109-1.6000.1096298435caucasian0.6000.4000.5650.435
Mahieu,1997 [0.68,1.48]1.000.2000.0001.000083129caucasian0.5540.4460.5540.446
Gutierrez,1997 [0.67,1.48]1.000.2000.0001.000088113caucasian0.5850.4150.5840.416
Tut,1999 [0.82,2.16]1.330.2471.1530.24917274asian0.3200.6800.3900.610
Massat,2000 [0.82,1.28]1.030.1110.2670.7898309309caucasian0.5230.4770.5290.471
Blairy,2000 [0.46,1.33]0.780.272-0.9130.36154089caucasian0.6000.4000.5400.460
Heiden,2000 [0.64,1.46]0.960.214-0.1910.848710279caucasian0.5300.4700.5300.470
Ranade,2003 [0.55,1.29]0.840.219-0.7970.42579392caucasian0.6500.3500.6100.390
Kumar,2007 [0.63,1.34]0.920.192-0.4350.6639102114asian0.5740.4260.5500.450
Kishi,2009 [0.96,1.56]1.220.1251.5850.1129155802asian0.4650.5350.5150.485
rs6314 [0.6,1.78]1.030.2790.1060.91579881004
Maria,1997 [0.83,1.7]1.190.1820.9560.3391298432caucasian0.9050.0950.9150.085
Gutierrez,1997 [0.68,2.93]1.410.3730.9210.357288113caucasian0.9090.0910.9340.066
Johansson,2001 [0.3,1.29]0.620.374-1.2790.20108282caucasian0.9210.0790.8780.122
Ranade,2003 [0.14,0.8]0.340.437-2.4710.01359392caucasian0.9600.0400.8900.110
Etain,2004 [0.49,1.22]0.770.235-1.1130.2657325171caucasian0.9220.0780.9010.099
Kumar,2007 [1.95,7.64]3.860.3483.8780.0001102114asian0.8240.1760.9470.053






Author Title    Journal Year PMID
Zhang,et al.  Serotonin2A receptor gene polymorphism in mood disorders.  Biol. Psychiatry  1997  9084895 
Arranz,et al.  5-HT2A receptor and bipolar affective disorder: association studies in affected patients.  Neurosci. Lett.  1997  9086465 
Mahieu,et al.  No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism.  Psychiatry Res  1997  9194200 
GutiĆ©rrez,et al.  Genetic variation of the 5-HT2A receptor gene and bipolar affective disorder.  Hum. Genet.  1997  9341875 
Vincent,et al.  Genetic association analysis of serotonin system genes in bipolar affective disorder.  Am J Psychiatry  1999  9892311 
Tut,et al.  Negative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese.  J Affect Disord  2000  10802129 
Massat,et al.  A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder.  Am. J. Med. Genet.  2000  10893484 
Blairy,et al.  5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait.  Am. J. Med. Genet.  2000  10898915 
Heiden,et al.  Association studies of candidate genes in bipolar disorders.  Neuropsychobiology  2000  11093065 
Johansson,et al.  Seasonal affective disorder and serotonin-related polymorphisms.  Neurobiol. Dis.  2001  11300730 
Murphy,et al.  No association between 5HT-2A and bipolar disorder irrespective of genomic imprinting.  Am. J. Med. Genet.  2001  11449393 
Chee,et al.  5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder.  Psychiatr. Genet.  2001  11702051 
Bonnier,et al.  Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk.  Biol. Psychiatry  2002  11983190 
Sklar,et al.  Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.  Mol. Psychiatry  2002  12140781 
Ni,et al.  Family-based association study of the serotonin-2A receptor gene (5-HT2A) and bipolar disorder.  Neuromolecular Med.  2002  12622403 
Ranade,et al.  Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2003  12898571 
Etain,et al.  Lack of association between 5HT2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2004  15274035 
Fallin,et al.  Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.  Am. J. Hum. Genet.  2005  16380905 
De Luca,et al.  Parent-of-origin effect and genomic imprinting of the HTR2A receptor gene T102C polymorphism in psychosis.  Psychiatry Res  2007  17407792 
Kumar,et al.  Serotonergic candidate genes and puerperal psychosis: an association study.  Psychiatr. Genet.  2007  17728663 
Kishi,et al.  Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population.  Neurosci. Res.  2009  19428704