Metamoodics Gene Information


  Chromosome: chrX    Cytoband: q23    Gene: HTR2C


BP - Candidate Gene Association Studies for HTR2C



Shown here are all published candidate gene association studies of gene HTR2C in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityGCGC
rs6318 [0.84,2.03]1.310.2231.2080.22698931074
Gutierez,1996 [0.67,2.9]1.390.3750.8780.380188113caucasian0.8800.1200.9100.090
Oruc,1997 [0.59,5.06]1.730.5481.0010.31684240caucasian0.8500.1500.9100.090
Lerer,2001 [0.81,1.28]1.020.1160.1710.8643649819caucasian0.8200.1800.8120.188
Kumar,2007 [0.95,21.53]4.520.7961.8940.0582114102asian0.9600.0400.9910.009






Author Title    Journal Year PMID
Oruc,et al.  Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder.  Am. J. Med. Genet.  1997  9342201 
Vincent,et al.  Genetic association analysis of serotonin system genes in bipolar affective disorder.  Am J Psychiatry  1999  9892311 
Johansson,et al.  Seasonal affective disorder and serotonin-related polymorphisms.  Neurobiol. Dis.  2001  11300730 
GutiĆ©rrez,et al.  Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder.  Neurosci. Lett.  2001  11502363 
Meyer,et al.  Evolutionary conserved microsatellites in the promoter region of the 5-hydroxytryptamine receptor 2C gene (HTR2C) are not associated with bipolar disorder in females.  J Neural Transm  2002  12111480 
Levitan,et al.  Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder.  Neuropsychopharmacology  2004  14560322 
Kumar,et al.  Serotonergic candidate genes and puerperal psychosis: an association study.  Psychiatr. Genet.  2007  17728663 
GutiĆ©rrez,et al.  Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder.  Neurosci. Lett.  1996  8823764