Metamoodics Gene Information

 

  Chromosome: chrX    Cytoband: p11.3    Gene: MAOA

 

BP - Candidate Gene Association Studies for MAOA


 

Description

 
Shown here are all published candidate gene association studies of gene MAOA in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 

 

 

 

 

 

 

Results Table

 

 

         freq_casesfreq_controls
Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicity
MAOA-CA(114/112) [0.42,1.71]0.840.363-0.4810.200305466
Craddock,1995 [0.13,10.9]1.21.1260.1620.0606762Caucasian0.5900.0400.1500.050
Lim,1995 [0.51,13.63]2.630.8391.1520.6034950Caucasian0.5820.0610.5050.020
Marumatsu,1997 [0.03,2.34]0.271.102-1.1880.6304476Asian0.3180.0110.2960.039
Furlong,1999 [0.16,2.14]0.590.657-0.8030.37580190Caucasian0.5190.0190.5130.032
Lin,2000 [0.22,2.85]0.80.648-0.3440.1366588Asian0.1600.0320.2170.054
 
MAOA-CA(114/116) [0.69,1.58]1.040.2130.1840.068447609
Craddock,1995 [0.23,2.23]0.720.577-0.5700.2456762Caucasian0.5900.1100.1500.040
Lim,1995 [0.72,4.25]1.750.4531.2360.6654950Caucasian0.5820.1840.5050.091
Kawaad,1995 [0.2,1.03]0.460.411-1.8881.2294552Asian0.4000.1330.3880.282
Rubinsztein,1996 [0.27,2.11]0.760.521-0.5270.2233030Caucasian0.6800.1700.4700.150
Parsian,1997 [0.77,9.37]2.680.6391.5440.9116761Caucasian0.0300.5300.0660.434
Marumatsu,1997 [0.22,1.59]0.590.506-1.0430.5274476Asian0.3180.0800.2960.125
Furlong,1999 [0.6,1.76]1.030.2730.1080.03980190Caucasian0.5190.1560.5130.150
Lin,2000 [0.97,4.38]2.060.3851.8781.2196588Asian0.1600.2230.2170.147
 
MAOA-CA(114/118) [0.68,3.39]1.520.4091.0230.514368529
Craddock,1995 [0.08,2.82]0.480.903-0.8120.3806762Caucasian0.5900.0300.1500.020
Kawaad,1995 [0.84,13.28]3.330.7061.7051.0544552Asian0.4000.1000.3880.029
Parsian,1997 [0.67,10.05]2.590.6921.3760.7726761Caucasian0.0300.1640.0660.139
Marumatsu,1997 [0.37,6.95]1.610.7460.6380.2814476Asian0.3180.0450.2960.026
Furlong,1999 [0.03,1.86]0.231.066-1.3780.77480190Caucasian0.5190.0060.5130.026
Lin,2000 [0.45,30.76]3.711.0791.2150.6496588Asian0.1600.0210.2170.008
 
MAOA-CA(114/120) [0.28,1.99]0.750.498-0.5780.249368529
Craddock,1995 [0.02,0.23]0.060.686-4.1044.3916762Caucasian0.5900.0200.1500.100
Kawaad,1995 [0.19,1.63]0.560.545-1.0640.5414552Asian0.4000.0670.3880.117
Parsian,1997 [0.53,14.74]2.80.8471.2150.6496761Caucasian0.0300.0520.0660.041
Marumatsu,1997 [0.27,1.54]0.640.448-0.9960.4964476Asian0.3180.1140.2960.164
Furlong,1999 [0.91,16.76]3.920.7411.8431.18580190Caucasian0.5190.0310.5130.008
Lin,2000 [0.41,2.36]0.990.443-0.0230.0086588Asian0.1600.0960.2170.132
 
MAOA-CA(114/122) [0.31,1.37]0.650.380-1.1320.589447609
Craddock,1995 [0.04,0.17]0.080.385-6.56810.2916762Caucasian0.5900.1800.1500.530
Lim,1995 [0.18,0.97]0.420.427-2.0311.3744950Caucasian0.5820.1020.5050.212
Kawaad,1995 [0.75,4.12]1.760.4341.3030.7154552Asian0.4000.2110.3880.117
Rubinsztein,1996 [0.11,1.02]0.340.561-1.9251.2653030Caucasian0.6800.1000.4700.200
Parsian,1997 [0.23,7.63]1.330.8910.3200.1266761Caucasian0.0300.0300.0660.049
Marumatsu,1997 [0.58,2.32]1.160.3540.4200.1714476Asian0.3180.2950.2960.237
Furlong,1999 [0.54,1.47]0.890.256-0.4550.18880190Caucasian0.5190.1750.5130.195
Lin,2000 [0.69,2.49]1.310.3280.8240.3876588Asian0.1600.4040.2170.419
 
MAOA-CA(114/124) [0.27,2.21]0.770.538-0.4860.203398559
Craddock,1995 [0.01,0.18]0.040.767-4.1954.5636762Caucasian0.5900.0100.1500.100
Kawaad,1995 [0.36,3.48]1.110.5830.1790.0674552Asian0.4000.0780.3880.068
Rubinsztein,1996 [0.04,11.38]0.681.438-0.2680.1033030Caucasian0.6800.0200.4700.020
Parsian,1997 [0.41,6.03]1.570.6870.6570.2916761Caucasian0.0300.1340.0660.189
Marumatsu,1997 [0.49,4.14]1.430.5420.6590.2934476Asian0.3180.0910.2960.059
Furlong,1999 [0.05,4.08]0.471.103-0.6850.30780190Caucasian0.5190.0060.5130.013
Lin,2000 [0.82,11.78]3.10.6811.6611.0156588Asian0.1600.0530.2170.023
 
MAOA-CA(114/126) [0.46,1.45]0.820.291-0.6820.305270407
Lim,1995 [0.08,1.31]0.330.703-1.5760.9394950Caucasian0.5820.0310.5050.081
Rubinsztein,1996 [0.02,2.3]0.231.175-1.2510.6763030Caucasian0.6800.0200.4700.050
Parsian,1997 [0.3,6.53]1.40.7860.4280.1756761Caucasian0.0300.0520.0660.082
Marumatsu,1997 [0.14,4.68]0.80.901-0.2480.0954476Asian0.3180.0230.2960.026
Furlong,1999 [0.5,2.48]1.120.4060.2790.10880190Caucasian0.5190.0630.5130.055
 
MAOA-RFLP-fnu [0.62,1.1]0.820.150-1.3240.732372527
Craddock,1995 [0.45,1.46]0.810.301-0.7010.3166552Caucasian0.7500.2500.7100.290
Lim,1995 [0.19,0.73]0.370.347-2.8682.3844847Europe0.8320.1680.6450.355
Rubinsztein,1996 [0.24,1.25]0.550.419-1.4270.8143030Cambrigde0.7900.2100.6700.330
Marumatsu,1997 [0.65,1.89]1.110.2720.3840.1544476Asian0.4090.5910.4340.566
Sasaki,1998 [0.7,1.46]1.010.1880.0530.019105131Asian0.5300.4700.5300.470
Furlong,1999 [0.66,1.48]0.990.205-0.0490.01780191Caucasian0.7060.2940.7030.297
 
MA0A-VNTR [0.35,1.29]0.670.334-1.1980.637229295
Craddock,1995 [0.44,1.57]0.830.325-0.5730.2475843Caucasian0.7500.2400.7200.280
Lim,1995 [0.16,0.62]0.320.337-3.3773.1345759Caucasian0.8060.1740.5860.394
Marumatsu,1997 [0.04,5.08]0.441.248-0.6580.2924476Asian0.0230.4430.0070.289
Gutierrez,2003 [0.7,1.75]1.110.2320.4490.18570117Caucasian0.2860.6930.3090.678
 

 

 

References

 

 

Author Title    Journal Year PMID
Parsian,et al.  Genetic association between monoamine oxidase and manic-depressive illness: comparison of relative risk and haplotype relative risk data.  Am. J. Med. Genet.  1997  9342194 
Muramatsu,et al.  Monoamine oxidase genes polymorphisms and mood disorder.  Am. J. Med. Genet.  1997  9342198 
Sasaki,et al.  The monoamine oxidase-A gene and major psychosis in Japanese subjects.  Biol. Psychiatry  1998  9807650 
Furlong,et al.  Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter.  Am. J. Med. Genet.  1999  10402508 
Kunugi,et al.  A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders.  Mol. Psychiatry  1999  10483059 
Lin,et al.  Association analysis between mood disorder and monoamine oxidase gene.  Am. J. Med. Genet.  2000  10686545 
Preisig,et al.  Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study.  Am J Psychiatry  2000  10831475 
Syagailo,et al.  Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders.  Am. J. Med. Genet.  2001  11304831 
Serretti,et al.  Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders.  Am. J. Med. Genet.  2002  11992558 
Gutiérrez,et al.  Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders.  Psychiatr. Genet.  2004  15564894 
Müller,et al.  Further evidence of MAO-A gene variants associated with bipolar disorder.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2007  16958037 
Craddock,et al.  No evidence for allelic association between bipolar disorder and monoamine oxidase A gene polymorphisms.  Am. J. Med. Genet.  1995  7485269 
Lim,et al.  Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder.  Am. J. Med. Genet.  1995  7485270 
Nöthen,et al.  Association analysis of the monoamine oxidase A gene in bipolar affective disorder by using family-based internal controls.  Am. J. Hum. Genet.  1995  7573065 
Kawada,et al.  Possible association between monoamine oxidase A gene and bipolar affective disorder.  Am. J. Hum. Genet.  1995  7880306 
Rubinsztein,et al.  Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and meta-analysis.  Hum. Mol. Genet.  1996  8776592 
Huang,et al.  Neither single-marker nor haplotype analyses support an association between monoamine oxidase A gene and bipolar disorder.  Eur Arch Psychiatry Clin Neurosci  2008  18437281