Metamoodics Gene Information


  Chromosome: chr1    Cytoband: p36.22    Gene: MTHFR


BP - Candidate Gene Association Studies for MTHFR



Shown here are all published candidate gene association studies of gene MTHFR in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityCTCT
rs1801133 [0.89,1.4]1.120.1140.9950.319512601911
Arinami,1997 [0.62,1.59]0.990.242-0.0420.966840419asian0.6250.3750.6230.377
Kunugi,1998 [1.01,1.81]1.350.1502.0060.0449143258asian0.5450.4550.6180.382
Tan,2004 [0.8,1.82]1.210.2080.9150.3601167120asian0.7720.2280.8040.196
Reif,2005 [0.53,1.15]0.780.198-1.2540.209792176caucasian0.7070.2930.6530.347
Kempisty,2006 [1.4,2.58]1.900.1564.1123.921E-05200300caucasian0.7230.2780.8320.168
Jonsson,2008 [0.58,1.18]0.830.180-1.0380.2993117177caucasian0.7050.2950.6640.336
Chen,2009 [0.84,1.2]1.000.0930.0001.0000501461asian0.5860.4140.5870.413






Author Title    Journal Year PMID
Arinami,et al.  Methylenetetrahydrofolate reductase variant and schizophrenia/depression.  Am. J. Med. Genet.  1997  9342205 
Kunugi,et al.  C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses.  Mol. Psychiatry  1998  9774778 
Tan,et al.  Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders.  Psychiatr. Genet.  2004  15564899 
Kempisty,et al.  Association of 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophrenia.  Neurosci. Lett.  2006  16545905 
Kempisty,et al.  Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia.  Eur. Psychiatry  2007  17188847 
Kempisty,et al.  MTHFD 1958G>A and MTR 2756A>G polymorphisms are associated with bipolar disorder and schizophrenia.  Psychiatr. Genet.  2007  17417062 
Chen,et al.  C677T methylenetetrahydrofolate reductase gene polymorphisms in bipolar disorder: an association study in the Chinese population and a meta-analysis of genetic association studies.  Neurosci. Lett.  2009  18983889 
J├Ânsson,et al.  Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2008  18165967