Metamoodics Gene Information


  Chromosome: chr17    Cytoband: q11.2    Gene: SLC6A4


BP - Candidate Gene Association Studies for SLC6A4



Shown here are all published candidate gene association studies of gene SLC6A4 in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicitylongshortlongshort
rs4795541 [0.95,1.16]1.050.0510.9600.47234954870
Collier,1996 [1.07,1.59]1.30.1032.5541.972305570Caucasian0.5200.4800.5730.426
Rees,1997 [0.61,1.19]0.850.172-0.9470.464168118Caucasian0.5900.4100.5500.450
Oruc,1997 [0.77,2.97]1.510.3451.1940.6344240Caucasian0.4400.5600.5500.450
Kunugi,1997 [0.59,1.28]0.870.197-0.7070.319140207Asian0.1860.8140.2080.792
Hoehe,1998 [0.78,1.59]1.110.1830.5690.24579281Caucasian0.5570.4430.5840.416
Furlong,1998 [0.77,1.61]1.110.1900.5500.23587174Caucasian0.5630.4360.5900.411
Oliveira,1998 [0.63,1.73]1.050.2550.1920.0724798Caucasian0.5960.4040.6170.383
Gutierrez,1998 [0.71,1.57]1.060.2000.2910.11388113Caucasian0.5170.4830.5310.469
Ohara,1998 [0.56,2.02]1.060.3290.1770.0663492Asian0.2500.7500.2390.761
Bellivier,1998 [0.87,1.74]1.230.1771.1700.61620499Caucasian0.5340.4660.5860.414
Ospina-Duque,2000 [0.58,1.24]0.850.193-0.8440.399103112Caucasian0.4700.5300.5100.490
Mellerup,2001 [0.56,1.36]0.870.228-0.6110.26766108Caucasian0.6200.3800.5900.410
Rotondo,2002 [1.09,2.25]1.570.1842.4571.853111127Caucasian0.4600.5400.5700.430
Hauser,2003 [1.18,2.19]1.610.1573.0342.617132213Caucasian0.4890.5110.6060.394
Mendlewicz,2004 [0.91,1.24]1.060.0800.7280.331572821Caucasian0.5400.4600.5550.445
Sun,2004 [0.51,1.3]0.820.235-0.8440.3998580Asian0.2880.7120.3310.669
Meira-Lima,2005 [0.69,1]0.830.095-1.9601.301429495Caucasian0.6030.3970.5630.437
Ikeda,2006 [0.58,1.27]0.860.199-0.7580.348109288Asian0.1930.8070.2170.783
Bogaert,2006 [0.82,1.38]1.060.1350.4330.177182364Caucasian0.5890.4110.6040.396
Kumar,2007 [0.94,2.01]1.380.1921.6791.031102114Asian0.5050.4950.4250.575
Vincze,2008 [0.63,0.95]0.780.101-2.4701.869410356Caucasian0.5880.4120.5860.414
rs57098334(12/10)¬† [0.79,1.07]0.920.077-1.0820.55418392737
Collier,1996 [0.41,0.75]0.550.158-3.7783.801191187Caucasian0.6700.3100.5400.450
Ogilvie,1996 [0.81,2.08]1.30.2401.0940.56244193Caucasian0.5230.4550.5930.396
Bellivier,1997 [0.67,1.53]1.010.2120.0470.01710986Caucasian0.6150.3800.6160.378
Rees,1997 [0.52,1.03]0.730.176-1.7921.136171121Caucasian0.6400.3500.5600.420
Kunugi,1997 [0.33,1]0.580.278-1.9601.301142212Asian0.9330.0670.8890.111
Hoehe,1998 [0.9,1.84]1.290.1811.4050.79679294Caucasian0.5440.4490.6020.386
Furlong,1998 [0.6,1.28]0.870.197-0.7070.31987174Caucasian0.6150.3560.5830.388
Gutierrez,1998 [0.75,1.76]1.150.2170.6440.28488113Caucasian0.6610.3330.6820.300
Bellivier,1998 [0.7,1.43]10.1820.0000.00019996Caucasian0.6210.3620.6250.300
Liu,1999 [0.6,1.67]10.2620.0000.000137362Asian0.9200.0800.9190.080
Saleem,2000 [0.42,1.45]0.780.316-0.7850.3645050Asian0.7500.2500.7000.300
Heiden,2000 [0.35,0.84]0.540.225-2.7332.20310279Caucasian0.6800.2900.5500.440
Mellerup,2001 [0.82,2.01]1.290.2261.1250.58466108Caucasian0.5700.4200.6200.360
Yen,2003 [0.57,2.12]1.10.3350.2850.11083169Asian0.9100.0900.0970.083
Sun,2004 [0.44,1.95]0.930.378-0.1920.0728091Asian0.9130.0880.9070.093
Ikeda,2006 [0.55,1.74]0.970.298-0.1020.037109288Asian0.9220.0780.9200.079
Kumar,2007 [0.78,1.82]1.190.2170.8020.374102114Asian0.7000.3000.7370.263
rs57098334(12/9) [0.57,1.59]0.950.263-0.1950.07311361451
Collier,1996 [0.16,3.91]0.780.822-0.3020.118191187Caucasian0.6700.0080.5400.008
Ogilvie,1996 [0.44,13.92]2.480.8801.0320.52044193Caucasian0.5230.0230.5930.010
Bellivier,1997 [0.05,12.8]0.791.421-0.1660.06110986Caucasian0.6150.0050.6160.006
Rees,1997 [0.18,2.19]0.620.644-0.7420.339171121Caucasian0.6400.0100.5600.020
Hoehe,1998 [0.07,4.84]0.591.074-0.4910.20579294Caucasian0.5440.0060.6020.012
Furlong,1998 [0.32,2.85]0.950.561-0.0920.03387174Caucasian0.6150.0290.5830.029
Gutierrez,1998 [0.04,2.96]0.331.119-0.9900.49288113Caucasian0.6610.0060.6820.018
Bellivier,1998 [0.35,8.31]1.70.8100.6550.29119996Caucasian0.6210.0170.6250.010
Heiden,2000 [0.3,8.24]1.560.8490.5240.22110279Caucasian0.6800.0300.5500.010
Mellerup,2001 [0.16,5.03]0.90.878-0.1200.04466108Caucasian0.5700.0100.6200.020






Author Title    Journal Year PMID
Bellivier,et al.  Serotonin transporter gene and manic depressive illness: an association study.  Biol. Psychiatry  1997  9067001 
Rees,et al.  Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT).  Mol. Psychiatry  1997  9322234 
Oruc,et al.  Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder.  Am. J. Med. Genet.  1997  9342201 
Kunugi,et al.  Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder.  Mol. Psychiatry    9399688 
Hoehe,et al.  Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders.  Am. J. Med. Genet.  1998  9514579 
Esterling,et al.  Serotonin transporter (5-HTT) gene and bipolar affective disorder.  Am. J. Med. Genet.  1998  9514585 
Furlong,et al.  Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders.  Am. J. Med. Genet.  1998  9514589 
Mendes de Oliveira,et al.  Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia.  Am. J. Med. Genet.  1998  9603609 
Guti√©rrez,et al.  Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population.  Biol. Psychiatry  1998  9611675 
Ohara,et al.  Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders.  Biol. Psychiatry  1998  9787878 
Bellivier,et al.  Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression.  Neurosci. Lett.  1998  9832193 
Geller,et al.  Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity.  Biol. Psychiatry  1999  10331118 
Bocchetta,et al.  Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia.  Am. J. Med. Genet.  1999  10490710 
Kirov,et al.  Bipolar disorder and the serotonin transporter gene: a family-based association study.  Psychol Med  1999  10576317 
Liu,et al.  Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese.  Pharmacogenetics  1999  10780268 
Saleem,et al.  Association analysis of 5HT transporter gene in bipolar disorder in the Indian population.  Am. J. Med. Genet.  2000  10893491 
Mundo,et al.  Lack of linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and bipolar disorder.  Am. J. Med. Genet.  2000  10898918 
Ospina-Duque,et al.  An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia.  Neurosci. Lett.  2000  11018311 
Heiden,et al.  Association studies of candidate genes in bipolar disorders.  Neuropsychobiology  2000  11093065 
Mynett-Johnson,et al.  Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder.  Am. J. Med. Genet.  2000  11121194 
Mellerup,et al.  Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients.  Acta Psychiatr Scand  2001  11240581 
Rotondo,et al.  Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder.  Am J Psychiatry  2002  11772685 
Serretti,et al.  Serotonin transporter gene (5-HTTLPR) and major psychoses.  Mol. Psychiatry  2002  11803453 
Piccardi,et al.  Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes.  Psychiatr. Genet.  2002  11901356 
Serretti,et al.  Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders.  Am. J. Med. Genet.  2002  11992558 
Sklar,et al.  Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.  Mol. Psychiatry  2002  12140781 
Dimitrova,et al.  Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studies.  Psychiatr. Genet.  2002  12218657 
Hauser,et al.  Association analysis of the insertion/deletion polymorphism in serotonin transporter gene in patients with affective disorder.  Eur. Psychiatry  2003  12763299 
Yen,et al.  Association study of serotonin transporter gene VNTR polymorphism and mood disorders, onset age and suicide attempts in a Chinese sample.  Neuropsychobiology  2003  12886033 
Mendlewicz,et al.  Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study.  Eur. J. Hum. Genet.  2004  14735161 
Sun,et al.  Sequence variants and haplotype analysis of serotonin transporter gene and association with bipolar affective disorder in Taiwan.  Pharmacogenetics  2004  15167705 
Ikeda,et al.  No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: association analysis based on linkage disequilibrium.  J Neural Transm  2006  16082508 
Meira-Lima,et al.  Allelic association analysis of the functional insertion/deletion polymorphism in the promoter region of the serotonin transporter gene in bipolar affective disorder.  J. Mol. Neurosci.  2005  16186633 
Van Den Bogaert,et al.  No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.  Psychiatr. Genet.  2006  16969276 
Kumar,et al.  Serotonergic candidate genes and puerperal psychosis: an association study.  Psychiatr. Genet.  2007  17728663 
Collier,et al.  The serotonin transporter is a potential susceptibility factor for bipolar affective disorder.  Neuroreport  1996  8904780 
Battersby,et al.  Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder.  Psychiatr. Genet.  1996  9149321 
Collier,et al.  A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.  Mol. Psychiatry  1996  9154246 
Alaerts,et al.  Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population.  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2009  18792946 
Vincze,et al.  Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene.  Bipolar Disord  2008  18657242 
Neves,et al.  Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients?  Am. J. Med. Genet. B Neuropsychiatr. Genet.  2008  17579356