|
Chromosome: chr17
Cytoband: q11.2
Gene: SLC6A4
|
|
BP - Candidate Gene Association Studies for SLC6A4
Shown here are all published candidate gene association studies of gene SLC6A4 in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.
|
rs4795541
 |
rs57098334
 |
rs57098334
 |
|
|
|
|
| | | | | | | | | freq_cases | freq_controls | Var/Study | 95%_CI | OR | SE | z-statistic | -log(p) | cases | controls | ethnicity | long | short | long | short | rs4795541 | [0.95,1.16] | 1.05 | 0.051 | 0.960 | 0.472 | 3495 | 4870 | | | | | | Collier,1996 | [1.07,1.59] | 1.3 | 0.103 | 2.554 | 1.972 | 305 | 570 | Caucasian | 0.520 | 0.480 | 0.573 | 0.426 | Rees,1997 | [0.61,1.19] | 0.85 | 0.172 | -0.947 | 0.464 | 168 | 118 | Caucasian | 0.590 | 0.410 | 0.550 | 0.450 | Oruc,1997 | [0.77,2.97] | 1.51 | 0.345 | 1.194 | 0.634 | 42 | 40 | Caucasian | 0.440 | 0.560 | 0.550 | 0.450 | Kunugi,1997 | [0.59,1.28] | 0.87 | 0.197 | -0.707 | 0.319 | 140 | 207 | Asian | 0.186 | 0.814 | 0.208 | 0.792 | Hoehe,1998 | [0.78,1.59] | 1.11 | 0.183 | 0.569 | 0.245 | 79 | 281 | Caucasian | 0.557 | 0.443 | 0.584 | 0.416 | Furlong,1998 | [0.77,1.61] | 1.11 | 0.190 | 0.550 | 0.235 | 87 | 174 | Caucasian | 0.563 | 0.436 | 0.590 | 0.411 | Oliveira,1998 | [0.63,1.73] | 1.05 | 0.255 | 0.192 | 0.072 | 47 | 98 | Caucasian | 0.596 | 0.404 | 0.617 | 0.383 | Gutierrez,1998 | [0.71,1.57] | 1.06 | 0.200 | 0.291 | 0.113 | 88 | 113 | Caucasian | 0.517 | 0.483 | 0.531 | 0.469 | Ohara,1998 | [0.56,2.02] | 1.06 | 0.329 | 0.177 | 0.066 | 34 | 92 | Asian | 0.250 | 0.750 | 0.239 | 0.761 | Bellivier,1998 | [0.87,1.74] | 1.23 | 0.177 | 1.170 | 0.616 | 204 | 99 | Caucasian | 0.534 | 0.466 | 0.586 | 0.414 | Ospina-Duque,2000 | [0.58,1.24] | 0.85 | 0.193 | -0.844 | 0.399 | 103 | 112 | Caucasian | 0.470 | 0.530 | 0.510 | 0.490 | Mellerup,2001 | [0.56,1.36] | 0.87 | 0.228 | -0.611 | 0.267 | 66 | 108 | Caucasian | 0.620 | 0.380 | 0.590 | 0.410 | Rotondo,2002 | [1.09,2.25] | 1.57 | 0.184 | 2.457 | 1.853 | 111 | 127 | Caucasian | 0.460 | 0.540 | 0.570 | 0.430 | Hauser,2003 | [1.18,2.19] | 1.61 | 0.157 | 3.034 | 2.617 | 132 | 213 | Caucasian | 0.489 | 0.511 | 0.606 | 0.394 | Mendlewicz,2004 | [0.91,1.24] | 1.06 | 0.080 | 0.728 | 0.331 | 572 | 821 | Caucasian | 0.540 | 0.460 | 0.555 | 0.445 | Sun,2004 | [0.51,1.3] | 0.82 | 0.235 | -0.844 | 0.399 | 85 | 80 | Asian | 0.288 | 0.712 | 0.331 | 0.669 | Meira-Lima,2005 | [0.69,1] | 0.83 | 0.095 | -1.960 | 1.301 | 429 | 495 | Caucasian | 0.603 | 0.397 | 0.563 | 0.437 | Ikeda,2006 | [0.58,1.27] | 0.86 | 0.199 | -0.758 | 0.348 | 109 | 288 | Asian | 0.193 | 0.807 | 0.217 | 0.783 | Bogaert,2006 | [0.82,1.38] | 1.06 | 0.135 | 0.433 | 0.177 | 182 | 364 | Caucasian | 0.589 | 0.411 | 0.604 | 0.396 | Kumar,2007 | [0.94,2.01] | 1.38 | 0.192 | 1.679 | 1.031 | 102 | 114 | Asian | 0.505 | 0.495 | 0.425 | 0.575 | Vincze,2008 | [0.63,0.95] | 0.78 | 0.101 | -2.470 | 1.869 | 410 | 356 | Caucasian | 0.588 | 0.412 | 0.586 | 0.414 | | | | | | | | | | | | | | rs57098334(12/10) | [0.79,1.07] | 0.92 | 0.077 | -1.082 | 0.554 | 1839 | 2737 | | | | | | Collier,1996 | [0.41,0.75] | 0.55 | 0.158 | -3.778 | 3.801 | 191 | 187 | Caucasian | 0.670 | 0.310 | 0.540 | 0.450 | Ogilvie,1996 | [0.81,2.08] | 1.3 | 0.240 | 1.094 | 0.562 | 44 | 193 | Caucasian | 0.523 | 0.455 | 0.593 | 0.396 | Bellivier,1997 | [0.67,1.53] | 1.01 | 0.212 | 0.047 | 0.017 | 109 | 86 | Caucasian | 0.615 | 0.380 | 0.616 | 0.378 | Rees,1997 | [0.52,1.03] | 0.73 | 0.176 | -1.792 | 1.136 | 171 | 121 | Caucasian | 0.640 | 0.350 | 0.560 | 0.420 | Kunugi,1997 | [0.33,1] | 0.58 | 0.278 | -1.960 | 1.301 | 142 | 212 | Asian | 0.933 | 0.067 | 0.889 | 0.111 | Hoehe,1998 | [0.9,1.84] | 1.29 | 0.181 | 1.405 | 0.796 | 79 | 294 | Caucasian | 0.544 | 0.449 | 0.602 | 0.386 | Furlong,1998 | [0.6,1.28] | 0.87 | 0.197 | -0.707 | 0.319 | 87 | 174 | Caucasian | 0.615 | 0.356 | 0.583 | 0.388 | Gutierrez,1998 | [0.75,1.76] | 1.15 | 0.217 | 0.644 | 0.284 | 88 | 113 | Caucasian | 0.661 | 0.333 | 0.682 | 0.300 | Bellivier,1998 | [0.7,1.43] | 1 | 0.182 | 0.000 | 0.000 | 199 | 96 | Caucasian | 0.621 | 0.362 | 0.625 | 0.300 | Liu,1999 | [0.6,1.67] | 1 | 0.262 | 0.000 | 0.000 | 137 | 362 | Asian | 0.920 | 0.080 | 0.919 | 0.080 | Saleem,2000 | [0.42,1.45] | 0.78 | 0.316 | -0.785 | 0.364 | 50 | 50 | Asian | 0.750 | 0.250 | 0.700 | 0.300 | Heiden,2000 | [0.35,0.84] | 0.54 | 0.225 | -2.733 | 2.203 | 102 | 79 | Caucasian | 0.680 | 0.290 | 0.550 | 0.440 | Mellerup,2001 | [0.82,2.01] | 1.29 | 0.226 | 1.125 | 0.584 | 66 | 108 | Caucasian | 0.570 | 0.420 | 0.620 | 0.360 | Yen,2003 | [0.57,2.12] | 1.1 | 0.335 | 0.285 | 0.110 | 83 | 169 | Asian | 0.910 | 0.090 | 0.097 | 0.083 | Sun,2004 | [0.44,1.95] | 0.93 | 0.378 | -0.192 | 0.072 | 80 | 91 | Asian | 0.913 | 0.088 | 0.907 | 0.093 | Ikeda,2006 | [0.55,1.74] | 0.97 | 0.298 | -0.102 | 0.037 | 109 | 288 | Asian | 0.922 | 0.078 | 0.920 | 0.079 | Kumar,2007 | [0.78,1.82] | 1.19 | 0.217 | 0.802 | 0.374 | 102 | 114 | Asian | 0.700 | 0.300 | 0.737 | 0.263 | | | | | | | | | | | | | | rs57098334(12/9) | [0.57,1.59] | 0.95 | 0.263 | -0.195 | 0.073 | 1136 | 1451 | | | | | | Collier,1996 | [0.16,3.91] | 0.78 | 0.822 | -0.302 | 0.118 | 191 | 187 | Caucasian | 0.670 | 0.008 | 0.540 | 0.008 | Ogilvie,1996 | [0.44,13.92] | 2.48 | 0.880 | 1.032 | 0.520 | 44 | 193 | Caucasian | 0.523 | 0.023 | 0.593 | 0.010 | Bellivier,1997 | [0.05,12.8] | 0.79 | 1.421 | -0.166 | 0.061 | 109 | 86 | Caucasian | 0.615 | 0.005 | 0.616 | 0.006 | Rees,1997 | [0.18,2.19] | 0.62 | 0.644 | -0.742 | 0.339 | 171 | 121 | Caucasian | 0.640 | 0.010 | 0.560 | 0.020 | Hoehe,1998 | [0.07,4.84] | 0.59 | 1.074 | -0.491 | 0.205 | 79 | 294 | Caucasian | 0.544 | 0.006 | 0.602 | 0.012 | Furlong,1998 | [0.32,2.85] | 0.95 | 0.561 | -0.092 | 0.033 | 87 | 174 | Caucasian | 0.615 | 0.029 | 0.583 | 0.029 | Gutierrez,1998 | [0.04,2.96] | 0.33 | 1.119 | -0.990 | 0.492 | 88 | 113 | Caucasian | 0.661 | 0.006 | 0.682 | 0.018 | Bellivier,1998 | [0.35,8.31] | 1.7 | 0.810 | 0.655 | 0.291 | 199 | 96 | Caucasian | 0.621 | 0.017 | 0.625 | 0.010 | Heiden,2000 | [0.3,8.24] | 1.56 | 0.849 | 0.524 | 0.221 | 102 | 79 | Caucasian | 0.680 | 0.030 | 0.550 | 0.010 | Mellerup,2001 | [0.16,5.03] | 0.9 | 0.878 | -0.120 | 0.044 | 66 | 108 | Caucasian | 0.570 | 0.010 | 0.620 | 0.020 | | | | | | | | | | | | | |
|
|
|
|
Author |
Title |
Journal |
Year |
PMID |
Bellivier,et al. | Serotonin transporter gene and manic depressive illness: an association study. | Biol. Psychiatry | 1997 | 9067001 | Rees,et al. | Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). | Mol. Psychiatry | 1997 | 9322234 | Oruc,et al. | Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder. | Am. J. Med. Genet. | 1997 | 9342201 | Kunugi,et al. | Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. | Mol. Psychiatry | | 9399688 | Hoehe,et al. | Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. | Am. J. Med. Genet. | 1998 | 9514579 | Esterling,et al. | Serotonin transporter (5-HTT) gene and bipolar affective disorder. | Am. J. Med. Genet. | 1998 | 9514585 | Furlong,et al. | Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. | Am. J. Med. Genet. | 1998 | 9514589 | Mendes de Oliveira,et al. | Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia. | Am. J. Med. Genet. | 1998 | 9603609 | Gutiérrez,et al. | Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population. | Biol. Psychiatry | 1998 | 9611675 | Ohara,et al. | Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders. | Biol. Psychiatry | 1998 | 9787878 | Bellivier,et al. | Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. | Neurosci. Lett. | 1998 | 9832193 | Geller,et al. | Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity. | Biol. Psychiatry | 1999 | 10331118 | Bocchetta,et al. | Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia. | Am. J. Med. Genet. | 1999 | 10490710 | Kirov,et al. | Bipolar disorder and the serotonin transporter gene: a family-based association study. | Psychol Med | 1999 | 10576317 | Liu,et al. | Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. | Pharmacogenetics | 1999 | 10780268 | Saleem,et al. | Association analysis of 5HT transporter gene in bipolar disorder in the Indian population. | Am. J. Med. Genet. | 2000 | 10893491 | Mundo,et al. | Lack of linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and bipolar disorder. | Am. J. Med. Genet. | 2000 | 10898918 | Ospina-Duque,et al. | An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia. | Neurosci. Lett. | 2000 | 11018311 | Heiden,et al. | Association studies of candidate genes in bipolar disorders. | Neuropsychobiology | 2000 | 11093065 | Mynett-Johnson,et al. | Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder. | Am. J. Med. Genet. | 2000 | 11121194 | Mellerup,et al. | Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients. | Acta Psychiatr Scand | 2001 | 11240581 | Rotondo,et al. | Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. | Am J Psychiatry | 2002 | 11772685 | Serretti,et al. | Serotonin transporter gene (5-HTTLPR) and major psychoses. | Mol. Psychiatry | 2002 | 11803453 | Piccardi,et al. | Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes. | Psychiatr. Genet. | 2002 | 11901356 | Serretti,et al. | Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders. | Am. J. Med. Genet. | 2002 | 11992558 | Sklar,et al. | Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. | Mol. Psychiatry | 2002 | 12140781 | Dimitrova,et al. | Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studies. | Psychiatr. Genet. | 2002 | 12218657 | Hauser,et al. | Association analysis of the insertion/deletion polymorphism in serotonin transporter gene in patients with affective disorder. | Eur. Psychiatry | 2003 | 12763299 | Yen,et al. | Association study of serotonin transporter gene VNTR polymorphism and mood disorders, onset age and suicide attempts in a Chinese sample. | Neuropsychobiology | 2003 | 12886033 | Mendlewicz,et al. | Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. | Eur. J. Hum. Genet. | 2004 | 14735161 | Sun,et al. | Sequence variants and haplotype analysis of serotonin transporter gene and association with bipolar affective disorder in Taiwan. | Pharmacogenetics | 2004 | 15167705 | Ikeda,et al. | No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: association analysis based on linkage disequilibrium. | J Neural Transm | 2006 | 16082508 | Meira-Lima,et al. | Allelic association analysis of the functional insertion/deletion polymorphism in the promoter region of the serotonin transporter gene in bipolar affective disorder. | J. Mol. Neurosci. | 2005 | 16186633 | Van Den Bogaert,et al. | No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population. | Psychiatr. Genet. | 2006 | 16969276 | Kumar,et al. | Serotonergic candidate genes and puerperal psychosis: an association study. | Psychiatr. Genet. | 2007 | 17728663 | Collier,et al. | The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. | Neuroreport | 1996 | 8904780 | Battersby,et al. | Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. | Psychiatr. Genet. | 1996 | 9149321 | Collier,et al. | A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. | Mol. Psychiatry | 1996 | 9154246 | Alaerts,et al. | Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population. | Am. J. Med. Genet. B Neuropsychiatr. Genet. | 2009 | 18792946 | Vincze,et al. | Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene. | Bipolar Disord | 2008 | 18657242 | Neves,et al. | Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients? | Am. J. Med. Genet. B Neuropsychiatr. Genet. | 2008 | 17579356 |
|
|