Shown here are all published candidate gene association studies of gene SLC6A4 in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.

 

 

 

 

 

 

 

									freq_cases		freq_controls
Var/Study	95%_CI	OR	SE	z-statistic	-log(p)	cases	controls	ethnicity	long	short	long	short
rs4795541	[0.95,1.16]	1.05	0.051	0.960	0.472	3495	4870
Collier,1996	[1.07,1.59]	1.3	0.103	2.554	1.972	305	570	Caucasian	0.520	0.480	0.573	0.426
Rees,1997	[0.61,1.19]	0.85	0.172	-0.947	0.464	168	118	Caucasian	0.590	0.410	0.550	0.450
Oruc,1997	[0.77,2.97]	1.51	0.345	1.194	0.634	42	40	Caucasian	0.440	0.560	0.550	0.450
Kunugi,1997	[0.59,1.28]	0.87	0.197	-0.707	0.319	140	207	Asian	0.186	0.814	0.208	0.792
Hoehe,1998	[0.78,1.59]	1.11	0.183	0.569	0.245	79	281	Caucasian	0.557	0.443	0.584	0.416
Furlong,1998	[0.77,1.61]	1.11	0.190	0.550	0.235	87	174	Caucasian	0.563	0.436	0.590	0.411
Oliveira,1998	[0.63,1.73]	1.05	0.255	0.192	0.072	47	98	Caucasian	0.596	0.404	0.617	0.383
Gutierrez,1998	[0.71,1.57]	1.06	0.200	0.291	0.113	88	113	Caucasian	0.517	0.483	0.531	0.469
Ohara,1998	[0.56,2.02]	1.06	0.329	0.177	0.066	34	92	Asian	0.250	0.750	0.239	0.761
Bellivier,1998	[0.87,1.74]	1.23	0.177	1.170	0.616	204	99	Caucasian	0.534	0.466	0.586	0.414
Ospina-Duque,2000	[0.58,1.24]	0.85	0.193	-0.844	0.399	103	112	Caucasian	0.470	0.530	0.510	0.490
Mellerup,2001	[0.56,1.36]	0.87	0.228	-0.611	0.267	66	108	Caucasian	0.620	0.380	0.590	0.410
Rotondo,2002	[1.09,2.25]	1.57	0.184	2.457	1.853	111	127	Caucasian	0.460	0.540	0.570	0.430
Hauser,2003	[1.18,2.19]	1.61	0.157	3.034	2.617	132	213	Caucasian	0.489	0.511	0.606	0.394
Mendlewicz,2004	[0.91,1.24]	1.06	0.080	0.728	0.331	572	821	Caucasian	0.540	0.460	0.555	0.445
Sun,2004	[0.51,1.3]	0.82	0.235	-0.844	0.399	85	80	Asian	0.288	0.712	0.331	0.669
Meira-Lima,2005	[0.69,1]	0.83	0.095	-1.960	1.301	429	495	Caucasian	0.603	0.397	0.563	0.437
Ikeda,2006	[0.58,1.27]	0.86	0.199	-0.758	0.348	109	288	Asian	0.193	0.807	0.217	0.783
Bogaert,2006	[0.82,1.38]	1.06	0.135	0.433	0.177	182	364	Caucasian	0.589	0.411	0.604	0.396
Kumar,2007	[0.94,2.01]	1.38	0.192	1.679	1.031	102	114	Asian	0.505	0.495	0.425	0.575
Vincze,2008	[0.63,0.95]	0.78	0.101	-2.470	1.869	410	356	Caucasian	0.588	0.412	0.586	0.414
rs57098334(12/10)	[0.79,1.07]	0.92	0.077	-1.082	0.554	1839	2737
Collier,1996	[0.41,0.75]	0.55	0.158	-3.778	3.801	191	187	Caucasian	0.670	0.310	0.540	0.450
Ogilvie,1996	[0.81,2.08]	1.3	0.240	1.094	0.562	44	193	Caucasian	0.523	0.455	0.593	0.396
Bellivier,1997	[0.67,1.53]	1.01	0.212	0.047	0.017	109	86	Caucasian	0.615	0.380	0.616	0.378
Rees,1997	[0.52,1.03]	0.73	0.176	-1.792	1.136	171	121	Caucasian	0.640	0.350	0.560	0.420
Kunugi,1997	[0.33,1]	0.58	0.278	-1.960	1.301	142	212	Asian	0.933	0.067	0.889	0.111
Hoehe,1998	[0.9,1.84]	1.29	0.181	1.405	0.796	79	294	Caucasian	0.544	0.449	0.602	0.386
Furlong,1998	[0.6,1.28]	0.87	0.197	-0.707	0.319	87	174	Caucasian	0.615	0.356	0.583	0.388
Gutierrez,1998	[0.75,1.76]	1.15	0.217	0.644	0.284	88	113	Caucasian	0.661	0.333	0.682	0.300
Bellivier,1998	[0.7,1.43]	1	0.182	0.000	0.000	199	96	Caucasian	0.621	0.362	0.625	0.300
Liu,1999	[0.6,1.67]	1	0.262	0.000	0.000	137	362	Asian	0.920	0.080	0.919	0.080
Saleem,2000	[0.42,1.45]	0.78	0.316	-0.785	0.364	50	50	Asian	0.750	0.250	0.700	0.300
Heiden,2000	[0.35,0.84]	0.54	0.225	-2.733	2.203	102	79	Caucasian	0.680	0.290	0.550	0.440
Mellerup,2001	[0.82,2.01]	1.29	0.226	1.125	0.584	66	108	Caucasian	0.570	0.420	0.620	0.360
Yen,2003	[0.57,2.12]	1.1	0.335	0.285	0.110	83	169	Asian	0.910	0.090	0.097	0.083
Sun,2004	[0.44,1.95]	0.93	0.378	-0.192	0.072	80	91	Asian	0.913	0.088	0.907	0.093
Ikeda,2006	[0.55,1.74]	0.97	0.298	-0.102	0.037	109	288	Asian	0.922	0.078	0.920	0.079
Kumar,2007	[0.78,1.82]	1.19	0.217	0.802	0.374	102	114	Asian	0.700	0.300	0.737	0.263
rs57098334(12/9)	[0.57,1.59]	0.95	0.263	-0.195	0.073	1136	1451
Collier,1996	[0.16,3.91]	0.78	0.822	-0.302	0.118	191	187	Caucasian	0.670	0.008	0.540	0.008
Ogilvie,1996	[0.44,13.92]	2.48	0.880	1.032	0.520	44	193	Caucasian	0.523	0.023	0.593	0.010
Bellivier,1997	[0.05,12.8]	0.79	1.421	-0.166	0.061	109	86	Caucasian	0.615	0.005	0.616	0.006
Rees,1997	[0.18,2.19]	0.62	0.644	-0.742	0.339	171	121	Caucasian	0.640	0.010	0.560	0.020
Hoehe,1998	[0.07,4.84]	0.59	1.074	-0.491	0.205	79	294	Caucasian	0.544	0.006	0.602	0.012
Furlong,1998	[0.32,2.85]	0.95	0.561	-0.092	0.033	87	174	Caucasian	0.615	0.029	0.583	0.029
Gutierrez,1998	[0.04,2.96]	0.33	1.119	-0.990	0.492	88	113	Caucasian	0.661	0.006	0.682	0.018
Bellivier,1998	[0.35,8.31]	1.7	0.810	0.655	0.291	199	96	Caucasian	0.621	0.017	0.625	0.010
Heiden,2000	[0.3,8.24]	1.56	0.849	0.524	0.221	102	79	Caucasian	0.680	0.030	0.550	0.010
Mellerup,2001	[0.16,5.03]	0.9	0.878	-0.120	0.044	66	108	Caucasian	0.570	0.010	0.620	0.020

 

 

Author	Title	Journal	Year	PMID
Bellivier,et al.	Serotonin transporter gene and manic depressive illness: an association study.	Biol. Psychiatry	1997	9067001
Rees,et al.	Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT).	Mol. Psychiatry	1997	9322234
Oruc,et al.	Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder.	Am. J. Med. Genet.	1997	9342201
Kunugi,et al.	Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder.	Mol. Psychiatry		9399688
Hoehe,et al.	Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders.	Am. J. Med. Genet.	1998	9514579
Esterling,et al.	Serotonin transporter (5-HTT) gene and bipolar affective disorder.	Am. J. Med. Genet.	1998	9514585
Furlong,et al.	Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders.	Am. J. Med. Genet.	1998	9514589
Mendes de Oliveira,et al.	Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia.	Am. J. Med. Genet.	1998	9603609
Gutiérrez,et al.	Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population.	Biol. Psychiatry	1998	9611675
Ohara,et al.	Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders.	Biol. Psychiatry	1998	9787878
Bellivier,et al.	Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression.	Neurosci. Lett.	1998	9832193
Geller,et al.	Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity.	Biol. Psychiatry	1999	10331118
Bocchetta,et al.	Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia.	Am. J. Med. Genet.	1999	10490710
Kirov,et al.	Bipolar disorder and the serotonin transporter gene: a family-based association study.	Psychol Med	1999	10576317
Liu,et al.	Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese.	Pharmacogenetics	1999	10780268
Saleem,et al.	Association analysis of 5HT transporter gene in bipolar disorder in the Indian population.	Am. J. Med. Genet.	2000	10893491
Mundo,et al.	Lack of linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and bipolar disorder.	Am. J. Med. Genet.	2000	10898918
Ospina-Duque,et al.	An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia.	Neurosci. Lett.	2000	11018311
Heiden,et al.	Association studies of candidate genes in bipolar disorders.	Neuropsychobiology	2000	11093065
Mynett-Johnson,et al.	Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder.	Am. J. Med. Genet.	2000	11121194
Mellerup,et al.	Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients.	Acta Psychiatr Scand	2001	11240581
Rotondo,et al.	Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder.	Am J Psychiatry	2002	11772685
Serretti,et al.	Serotonin transporter gene (5-HTTLPR) and major psychoses.	Mol. Psychiatry	2002	11803453
Piccardi,et al.	Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes.	Psychiatr. Genet.	2002	11901356
Serretti,et al.	Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders.	Am. J. Med. Genet.	2002	11992558
Sklar,et al.	Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.	Mol. Psychiatry	2002	12140781
Dimitrova,et al.	Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studies.	Psychiatr. Genet.	2002	12218657
Hauser,et al.	Association analysis of the insertion/deletion polymorphism in serotonin transporter gene in patients with affective disorder.	Eur. Psychiatry	2003	12763299
Yen,et al.	Association study of serotonin transporter gene VNTR polymorphism and mood disorders, onset age and suicide attempts in a Chinese sample.	Neuropsychobiology	2003	12886033
Mendlewicz,et al.	Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study.	Eur. J. Hum. Genet.	2004	14735161
Sun,et al.	Sequence variants and haplotype analysis of serotonin transporter gene and association with bipolar affective disorder in Taiwan.	Pharmacogenetics	2004	15167705
Ikeda,et al.	No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: association analysis based on linkage disequilibrium.	J Neural Transm	2006	16082508
Meira-Lima,et al.	Allelic association analysis of the functional insertion/deletion polymorphism in the promoter region of the serotonin transporter gene in bipolar affective disorder.	J. Mol. Neurosci.	2005	16186633
Van Den Bogaert,et al.	No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.	Psychiatr. Genet.	2006	16969276
Kumar,et al.	Serotonergic candidate genes and puerperal psychosis: an association study.	Psychiatr. Genet.	2007	17728663
Collier,et al.	The serotonin transporter is a potential susceptibility factor for bipolar affective disorder.	Neuroreport	1996	8904780
Battersby,et al.	Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder.	Psychiatr. Genet.	1996	9149321
Collier,et al.	A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.	Mol. Psychiatry	1996	9154246
Alaerts,et al.	Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population.	Am. J. Med. Genet. B Neuropsychiatr. Genet.	2009	18792946
Vincze,et al.	Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene.	Bipolar Disord	2008	18657242
Neves,et al.	Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients?	Am. J. Med. Genet. B Neuropsychiatr. Genet.	2008	17579356