Metamoodics Gene Information

 

  Chromosome: chr11    Cytoband: p15.5    Gene: TH

 

BP - Candidate Gene Association Studies for TH


 

Description

 
Shown here are all published candidate gene association studies of gene TH in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 

 

 

 

 

 

 

Results Table

 

 

         freq_casesfreq_controls
Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicity
HUMTH01(5/1) [0.77,1.09]0.920.087-0.9640.47510241182
Korner,1994 [0.68,1.5]1.010.2020.0490.017183209caucasian0.2000.3200.2100.330
Meloni,1995 [0.55,2.04]1.060.3340.1740.0656464caucasian0.3440.2580.3200.227
Castro,1995 [0.72,3.2]1.520.3801.1020.5686048caucasian0.2830.3580.2500.208
Sourey,1996 [0.56,2.05]1.070.3320.2040.0776667caucasian0.2200.2580.3060.336
Oruc,1997 [0.47,2.05]0.980.377-0.0540.0194270caucasian0.2500.2900.2600.310
Serretti,1998 [0.27,0.94]0.510.312-2.1581.5108884caucasian0.2220.2050.1960.357
Furlong,1999 [0.47,1.11]0.720.221-1.4870.864120239caucasian0.2380.2580.2240.339
Souery,1999 [0.72,1.24]0.950.136-0.3770.151401401caucasian0.2470.2810.2460.294
 
HUMTH01(5/2) [0.94,1.37]1.130.0981.2440.67010981260
Korner,1994 [0.69,1.74]1.090.2390.3610.144183209caucasian0.2000.1600.2100.160
Kawada,1995 [0.56,1.98]1.050.3240.1510.0557478asian0.4530.1690.5060.179
Meloni,1995 [0.64,2.81]1.350.3740.8020.3746464caucasian0.3440.2030.3200.141
Castro,1995 [0.25,1.24]0.550.415-1.4410.8256048caucasian0.2830.1500.2500.240
Sourey,1996 [1.04,4.85]2.250.3922.0691.4146667caucasian0.2200.2050.3060.127
Oruc,1997 [0.38,1.91]0.850.413-0.3930.1594270caucasian0.2500.1900.2600.240
Serretti,1998 [0.85,3.24]1.660.3411.4850.8628884caucasian0.2220.2780.1960.149
Furlong,1999 [0.59,1.67]0.990.267-0.0380.013120239caucasian0.2380.1500.2240.142
Souery,1999 [0.83,1.55]1.130.1610.7580.348401401caucasian0.2470.1760.2460.155
 
HUMTH01(5/3) [0.88,1.37]1.10.1120.8510.404763926
Korner,1994 [0.8,2.27]1.350.2651.1320.589183209caucasian0.2000.1300.2100.100
Kawada,1995 [0.74,2.19]1.270.2780.8600.4097478asian0.4530.2840.5060.250
Meloni,1995 [0.18,1.09]0.440.463-1.7741.1196464caucasian0.3440.0700.3200.148
Castro,1995 [0.19,1.16]0.470.461-1.6380.9946048caucasian0.2830.1000.2500.188
Sourey,1996 [0.65,3.45]1.50.4250.9540.4696667caucasian0.2200.1290.3060.120
Oruc,1997 [0.57,3.91]1.490.4920.8100.3794270caucasian0.2500.1300.2600.090
Serretti,1998 [0.54,2.4]1.140.3800.3450.1378884caucasian0.2220.1530.1960.119
Furlong,1999 [0.69,2.05]1.190.2770.6270.275120239caucasian0.2380.1380.2240.109
Souery,1999 [0.78,1.54]1.10.1720.5550.2386667caucasian0.2470.1330.2460.121
 
HUMTH01(5/4) [0.82,1.2]0.990.098-0.1020.03710981260
Korner,1994 [0.65,1.56]10.2270.0000.000183209caucasian0.2000.1900.2100.200
Kawada,1995 [0.48,3.63]1.330.5120.5570.2387478asian0.4530.0610.5060.051
Meloni,1995 [0.33,1.54]0.710.395-0.8670.4136464caucasian0.3440.1250.3200.164
Castro,1995 [0.32,2.17]0.830.490-0.3800.1526048caucasian0.2830.1080.2500.115
Sourey,1996 [1.06,5.23]2.360.4062.1151.4636667caucasian0.2200.1890.3060.111
Oruc,1997 [0.59,3.86]1.510.4790.8610.4104270caucasian0.2500.1400.2600.100
Serretti,1998 [0.35,1.43]0.710.357-0.9590.4718884caucasian0.2220.1420.1960.179
Furlong,1999 [0.69,1.77]1.110.2380.4380.180120239caucasian0.2380.2170.2240.184
Souery,1999 [0.65,1.2]0.880.158-0.8080.378401401caucasian0.2470.1630.2460.185
 

 

 

References

 

 

Author Title    Journal Year PMID
Oruc,et al.  Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients.  Am. J. Med. Genet.  1997  9129719 
Malafosse,et al.  Manic depressive illness and tyrosine hydroxylase gene: linkage heterogeneity and association.  Neurobiol. Dis.  1997  9440122 
Serretti,et al.  Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders.  Mol. Psychiatry  1998  9577842 
Burgert,et al.  No association between the tyrosine hydroxylase microsatellite marker HUMTH01 and schizophrenia or bipolar I disorder.  Psychiatr. Genet.  1998  9686421 
Furlong,et al.  Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders.  Am. J. Med. Genet.  1999  10050974 
Souery,et al.  Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: a multicenter association study.  Am. J. Med. Genet.  1999  10490711 
Sklar,et al.  Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.  Mol. Psychiatry  2002  12140781 
Muglia,et al.  Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4.  Mol. Psychiatry  2002  12232779 
Gill,et al.  Tyrosine hydroxylase polymorphisms and bipolar affective disorder.  J Psychiatr Res  1991  1685750 
Leboyer,et al.  Tyrosine hydroxylase polymorphisms associated with manic-depressive illness.  Lancet  1990  1971057 
Körner,et al.  RFLP alleles at the tyrosine hydroxylase locus: no association found to affective disorders.  Psychiatry Res  1990  1975102 
Kawada,et al.  No evidence of linkage or association between tyrosine hydroxylase gene and affective disorder.  J Affect Disord  1995  7665810 
Meloni,et al.  Association of manic-depressive illness with tyrosine hydroxylase microsatellite marker.  Lancet  1995  7707843 
Körner,et al.  Association and haplotype analysis at the tyrosine hydroxylase locus in a combined German-British sample of manic depressive patients and controls.  Psychiatr. Genet.  1994  7719703 
Pérez de Castro,et al.  A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.  J. Med. Genet.  1995  7760324 
Inayama,et al.  Lack of association between bipolar affective disorder and tyrosine hydroxylase DNA marker.  Am. J. Med. Genet.  1993  8103293 
Souery,et al.  Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes.  Am. J. Med. Genet.  1996  8950413