Metamoodics Gene Information


  Chromosome: chr6    Cytoband: p21.33    Gene: TNF


BP - Candidate Gene Association Studies for TNF



Shown here are all published candidate gene association studies of gene TNF in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityGAGA
rs1800629 [0.64,2.09]1.150.3050.4590.64666671205
Middle,2000 [0.47,1.57]0.860.307-0.4910.62335672caucasian0.800000.200000.780000.22000
Meira-Lima,2003 [0.62,1.36]0.920.199-0.4180.6759161657caucasian0.895000.105000.885000.11500
Pae,2004 [1.92,6.37]3.50.3064.1004.126E-0589125asian0.787000.213000.928000.07200
Czerski,2008 [0.55,0.98]0.730.150-2.0940.0362361351caucasian0.868000.132000.829000.17100






Author Title    Journal Year PMID
Middle,et al.  Tumour necrosis factor alpha and bipolar affective puerperal psychosis.  Psychiatr. Genet.  2000  11324946 
Meira-Lima,et al.  Analysis of a polymorphism in the promoter region of the tumor necrosis factor alpha gene in schizophrenia and bipolar disorder: further support for an association with schizophrenia.  Mol. Psychiatry  2003  12888800 
Pae,et al.  Tumor necrosis factor alpha gene-G308A polymorphism associated with bipolar I disorder in the Korean population.  Psychiatry Res  2004  14967554 
Czerski,et al.  Association of tumor necrosis factor -308G/A promoter polymorphism with schizophrenia and bipolar affective disorder in a Polish population.  Neuropsychobiology  2008  18515978