Metamoodics Gene Information


  Chromosome: chr11    Cytoband: p15.1    Gene: TPH1


BP - Candidate Gene Association Studies for TPH1



Shown here are all published candidate gene association studies of gene TPH1 in bipolar disorder as of 05/01/2013. For genes with three or more case-control studies, a meta-analysis has been carried out. The results of meta-analysis are graphically displayed in the Results Figure, and key data from each of the studies are provided in the Results Table. Details of the methods for carrying out the meta-analysis are provided here.



Results Figure








Results Table



Var/Study 95%_CIORSEz-statistic-log(p)casescontrolsethnicityGTGT
rs1800532 [1.09,1.41]1.240.0663.2820.001018482075
Bellevier,1998 [1.33,2.8]1.930.1903.4630.000515294caucasian0.4800.5200.6400.360
Furlong,1998 [0.88,1.58]1.180.1491.1110.2664118437caucasian0.5680.4320.6090.391
Kunugi,1999 [0.99,1.82]1.340.1561.8740.0610141208asian0.4110.5890.4830.517
Tsai,1999 [0.9,1.86]1.30.1831.4360.151183200asian0.4880.5120.5530.448
Souery,2001 [0.85,1.21]1.020.0870.2270.8203527527caucasian0.5800.4200.5900.410
Serretti,2001 [0.95,1.37]1.140.0941.3970.1623627380caucasian0.5910.4090.6220.378
Rotondo,2002 [0.95,1.96]1.370.1831.7230.0849111127caucasian0.4500.5500.5200.480
Lai,2005 [0.88,1.99]1.320.2091.3260.185089102asian0.5400.4600.6100.390






Author Title    Journal Year PMID
Bellivier,et al.  Association between the tryptophan hydroxylase gene and manic-depressive illness.  Arch. Gen. Psychiatry  1998  9435758 
Furlong,et al.  No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder.  Am. J. Med. Genet.  1998  9603613 
Kunugi,et al.  No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients.  Am J Psychiatry  1999  10327914 
Tsai,et al.  Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.  Neuroreport  1999  10716208 
Rietschel,et al.  Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls.  Am. J. Med. Genet.  2000  10898906 
Souery,et al.  Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study.  Biol. Psychiatry  2001  11274651 
Serretti,et al.  Tryptophan hydroxylase gene and major psychoses.  Psychiatry Res  2001  11472792 
Rotondo,et al.  Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder.  Am J Psychiatry  2002  11772685 
Serretti,et al.  Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders.  Am. J. Med. Genet.  2002  11992558 
Lai,et al.  Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan.  BMC Med. Genet.  2005  15799788