Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: p13.3    Gene: ADCY9

 

BP - Genomewide Expression Studies for ADCY9


 

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Description

 
Shown here are the results for gene ADCY9 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.07270.0467 1.03[-1.07,1.14]0.5250.999204497_at
Harvard.FrontalFrontalHGU133A0.0547-0.0702-1.05[-1.13,1.03]0.2060.94204497_at
Harvard.HippHippocampusHGU95AV20.125-0.0738-1.05[-1.25,1.13]0.5660.80133800_at
AltarAFrontalBA46HGU133A0.04740.0845 1.06[-1.01,1.13]0.07950.3611204497_at
BahnFrontalBA46HGU133A0.05680.0577 1.04[-1.04,1.12]0.3140.831204497_at
ChenFrontalBA46HGU133P0.06950.0284 1.02[-1.08,1.12]0.6860.965204497_at
DobrinFrontalBA46HGU133P0.05970.0896 1.06[-1.02,1.15]0.1410.948204497_at
KatoFrontalBA46HGU133A0.03790.0767 1.05[1,1.11]0.04760.625204497_at
KemetherThalamusHGU133P0.0715-0.0809-1.06[-1.17,1.04]0.2710.815204497_at
LaengHippocampusHGU133P0.034-0.0074-1.01[-1.05,1.04]0.8280.999204497_at
          
megaanalysisAny_BrainHGU1330.02360.027 1.02[-1.01,1.05]0.2520.801 
megaanalysisFrontal_CortexHGU1330.02690.0365 1.03[-1.01,1.06]0.1750.62204 
megaanalysisHippocampusHGU133&HGU950.0397-0.0246-1.02[-1.07,1.04]0.5380.991 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.0807-0.4364-1.35[-1.51,-1.21]2.71e-057.75e-05204497_at
FeinbergCerebellumHGU95AV20.0478-0.0063-1.00[-1.07,1.06]0.8959180.98933800_at
KatoBFrontalBA10HGU95AV20.06480.0871 1.06[-1.03,1.16]0.1912170.60733800_at
SklarAFrontalBA8.9HGU95AV20.13890.2776 1.21[1.00,1.46]0.06097133800_at
SklarBCerebellumHGU95AV20.08100.0123 1.01[-1.11,1.13]0.8813830.99733800_at
SokolovTemporal.CortexHGU95AV20.07640.0210 1.01[-1.09,1.13]0.7857530.96133800_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.