Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q21.2    Gene: ANK3

 

BP - Genomewide Expression Studies for ANK3


 

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Description

 
Shown here are the results for gene ANK3 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.0894-0.0433-1.03[-1.16,1.1]0.6310.999206385_s_at
Harvard.FrontalFrontalHGU133A0.053-0.1016-1.07[-1.15,1]0.06180.93206385_s_at
Harvard.HippHippocampusHGU95AV20.06060.0958 1.07[-1.02,1.16]0.140.44936965_at
AltarAFrontalBA46HGU133A0.0355-0.0642-1.05[-1.1,1]0.07550.3513206385_s_at
BahnFrontalBA46HGU133A0.0403-0.0454-1.03[-1.09,1.02]0.2640.802206385_s_at
ChenFrontalBA46HGU133P0.0588-0.0608-1.04[-1.13,1.04]0.3110.865238786_at
DobrinFrontalBA46HGU133P0.0581-0.0856-1.06[-1.15,1.02]0.1480.948238786_at
KatoFrontalBA46HGU133A0.0369-0.0311-1.02[-1.07,1.03]0.4030.878206385_s_at
KemetherThalamusHGU133P0.0885-0.1499-1.11[-1.25,1.02]0.1050.719238786_at
LaengHippocampusHGU133P0.0460.0058 1[-1.06,1.07]0.90.999238786_at
          
megaanalysisAny_BrainHGU1330.0225-0.066-1.05[-1.08,-1.02]0.003540.261 
megaanalysisFrontal_CortexHGU1330.0228-0.0687-1.05[-1.08,-1.02]0.002850.14763 
megaanalysisHippocampusHGU133&HGU950.03730.0291 1.02[-1.03,1.07]0.4390.99 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.0523-0.1817-1.13[-1.22,-1.06]0.00240.003849206385_s_at
FeinbergCerebellumHGU95AV20.0454-0.1238-1.09[-1.16,-1.02]0.0117960.89436965_at
KatoBFrontalBA10HGU95AV20.0386-0.0935-1.07[-1.12,-1.01]0.0233400.33636965_at
SklarAFrontalBA8.9HGU95AV20.1370-0.1571-1.12[-1.34,1.08]0.26668136965_at
SklarBCerebellumHGU95AV20.1304-0.0051-1.00[-1.20,1.19]0.9689930.99736965_at
SokolovTemporal.CortexHGU95AV20.0962-0.1552-1.11[-1.27,1.02]0.1203520.75936965_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.