Metamoodics Gene Information

 

  Chromosome: chr12    Cytoband: p13.33    Gene: CACNA1C

 

BP - Genomewide Expression Studies for CACNA1C


 

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Description

 
Shown here are the results for gene CACNA1C from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.HippHippocampusHGU95AV20.13970.2012 1.15[-1.05,1.39]0.1760.49138001_at
ChenFrontalBA46HGU133P0.05770.0571 1.04[-1.04,1.13]0.3320.87242973_at
DobrinFrontalBA46HGU133P0.0556-0.0284-1.02[-1.1,1.06]0.6110.981242973_at
KemetherThalamusHGU133P0.1138-8e-04-1[-1.17,1.17]0.9940.998242973_at
LaengHippocampusHGU133P0.04950.071 1.05[-1.02,1.12]0.160.999242973_at
          
megaanalysisAny_BrainHGU1330.03210.0217 1.02[-1.03,1.06]0.4990.907 
megaanalysisHippocampusHGU133&HGU950.05060.1048 1.08[1,1.15]0.04330.856 
 
* Additional studies not included in megaanalysis     
FeinbergCerebellumHGU95AV20.04620.0169 1.01[-1.05,1.08]0.7174730.97238001_at
KatoBFrontalBA10HGU95AV20.05350.0201 1.01[-1.06,1.09]0.7103120.90938001_at
SklarAFrontalBA8.9HGU95AV20.0955-0.0279-1.02[-1.16,1.12]0.77371138001_at
SklarBCerebellumHGU95AV20.08540.0396 1.03[-1.09,1.15]0.6479350.98938001_at
SokolovTemporal.CortexHGU95AV20.07530.1223 1.09[-1.02,1.21]0.1181330.75938001_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.