Metamoodics Gene Information

 

  Chromosome: chr22    Cytoband: q11.21    Gene: COMT

 

BP - Genomewide Expression Studies for COMT


 

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Description

 
Shown here are the results for gene COMT from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.04060.0407 1.03[-1.03,1.09]0.3230.999213981_at
Harvard.FrontalFrontalHGU133A0.0308-0.0287-1.02[-1.06,1.02]0.3560.958213981_at
Harvard.HippHippocampusHGU95AV20.1253-0.0266-1.02[-1.21,1.16]0.8350.93734651_at
AltarAFrontalBA46HGU133A0.01770.006 1[-1.02,1.03]0.7340.9017213981_at
BahnFrontalBA46HGU133A0.032-0.0365-1.03[-1.07,1.02]0.2580.799213981_at
ChenFrontalBA46HGU133P0.05130.0575 1.04[-1.03,1.12]0.2730.846213981_at
DobrinFrontalBA46HGU133P0.06390.0763 1.05[-1.03,1.15]0.2380.953213981_at
KatoFrontalBA46HGU133A0.03260.0093 1.01[-1.04,1.05]0.7770.966213981_at
KemetherThalamusHGU133P0.0804-0.063-1.04[-1.17,1.07]0.4420.867213981_at
LaengHippocampusHGU133P0.03850.0095 1.01[-1.05,1.06]0.8070.999213981_at
          
megaanalysisAny_BrainHGU1330.01540.0084 1.01[-1.02,1.03]0.5880.931 
megaanalysisFrontal_CortexHGU1330.0170.0078 1.01[-1.02,1.03]0.6480.90733 
megaanalysisHippocampusHGU133&HGU950.04181e-04 1[-1.06,1.06]0.9980.999 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.0480.2005 1.15[1.08,1.23]0.0004690.000886213981_at
FeinbergCerebellumHGU95AV20.0481-0.0052-1.00[-1.07,1.06]0.9149400.99334651_at
KatoBFrontalBA10HGU95AV20.06470.0067 1.00[-1.09,1.10]0.9179260.97934651_at
SklarAFrontalBA8.9HGU95AV20.09110.0211 1.01[-1.12,1.15]0.81908134651_at
SklarBCerebellumHGU95AV20.07030.0642 1.05[-1.05,1.15]0.3722210.97834651_at
SokolovTemporal.CortexHGU95AV20.0599-0.0672-1.05[-1.14,1.04]0.2732930.79934651_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.