Metamoodics Gene Information

 

  Chromosome: chr11    Cytoband: q23.1-q23.2    Gene: DRD2

 

BP - Genomewide Expression Studies for DRD2


 

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Description

 
Shown here are the results for gene DRD2 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.0515-0.0217-1.02[-1.09,1.06]0.6760.999216938_x_at
Harvard.FrontalFrontalHGU133A0.0352-0.0335-1.02[-1.07,1.02]0.3460.954216938_x_at
Harvard.HippHippocampusHGU95AV20.04220.1054 1.08[1.02,1.14]0.0280.26640371_at
AltarAFrontalBA46HGU133A0.02110.0635 1.05[1.02,1.08]0.003880.1084216938_x_at
BahnFrontalBA46HGU133A0.0330.0152 1.01[-1.03,1.06]0.6460.928216938_x_at
ChenFrontalBA46HGU133P0.0506-0.0277-1.02[-1.09,1.05]0.5890.945216938_x_at
DobrinFrontalBA46HGU133P0.0488-0.0335-1.02[-1.09,1.04]0.4960.969216938_x_at
KatoFrontalBA46HGU133A0.02620.0509 1.04[-1,1.07]0.05630.642216938_x_at
KemetherThalamusHGU133P0.0477-0.0391-1.03[-1.1,1.04]0.4220.862216938_x_at
LaengHippocampusHGU133P0.0387-0.0547-1.04[-1.09,1.01]0.1650.999216938_x_at
          
megaanalysisAny_BrainHGU1330.01248e-04 1[-1.02,1.02]0.9480.994 
megaanalysisFrontal_CortexHGU1330.01440.0132 1.01[-1.01,1.03]0.3610.78004 
megaanalysisHippocampusHGU133&HGU950.0318-0.0132-1.01[-1.05,1.03]0.680.992 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.05630.4054 1.32[1.23,1.43]5.76e-074.95e-06216938_x_at
FeinbergCerebellumHGU95AV20.0274-0.0198-1.01[-1.05,1.02]0.4776960.93540371_at
KatoBFrontalBA10HGU95AV20.0299-0.0298-1.02[-1.06,1.02]0.3287180.72140371_at
SklarAFrontalBA8.9HGU95AV20.05250.0050 1.00[-1.07,1.08]0.92484140371_at
SklarBCerebellumHGU95AV20.04600.0332 1.02[-1.04,1.09]0.4787920.97840371_at
SokolovTemporal.CortexHGU95AV20.0614-0.0163-1.01[-1.10,1.07]0.7923940.96340371_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.