Metamoodics Gene Information

 

  Chromosome: chr3    Cytoband: q27.1    Gene: DVL3

 

BP - Genomewide Expression Studies for DVL3


 

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Description

 
Shown here are the results for gene DVL3 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.1291-0.1699-1.12[-1.34,1.06]0.1970.999201908_at
Harvard.FrontalFrontalHGU133A0.0685-0.1329-1.1[-1.2,1]0.0590.93201908_at
Harvard.HippHippocampusHGU95AV20.05320.0259 1.02[-1.06,1.09]0.6350.83940873_at
AltarAFrontalBA46HGU133A0.04820.051 1.04[-1.03,1.11]0.2940.6352201908_at
BahnFrontalBA46HGU133A0.04880.0119 1.01[-1.06,1.08]0.8090.968201908_at
ChenFrontalBA46HGU133P0.07060.1 1.07[-1.03,1.18]0.1690.803201908_at
DobrinFrontalBA46HGU133P0.08020.1221 1.09[-1.02,1.21]0.1350.948201908_at
KatoFrontalBA46HGU133A0.0370.0576 1.04[-1.01,1.09]0.1240.73201908_at
KemetherThalamusHGU133P0.0948-0.308-1.24[-1.41,-1.09]0.003850.701201908_at
LaengHippocampusHGU133P0.0369-0.0243-1.02[-1.07,1.03]0.5140.999201908_at
          
megaanalysisAny_BrainHGU1330.0251-0.0182-1.01[-1.05,1.02]0.4680.894 
megaanalysisFrontal_CortexHGU1330.02560.0299 1.02[-1.01,1.06]0.2440.6833 
megaanalysisHippocampusHGU133&HGU950.0302-0.0113-1.01[-1.05,1.03]0.7110.993 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.074-0.1154-1.08[-1.2,1.02]0.1350.160934201908_at
FeinbergCerebellumHGU95AV20.05020.0005 1.00[-1.07,1.07]0.9924650.99940873_at
KatoBFrontalBA10HGU95AV20.0778-0.0460-1.03[-1.15,1.08]0.5596040.84640873_at
SklarAFrontalBA8.9HGU95AV20.1291-0.0806-1.06[-1.26,1.13]0.53993140873_at
SklarBCerebellumHGU95AV20.11510.0332 1.02[-1.14,1.20]0.7760400.99440873_at
SokolovTemporal.CortexHGU95AV20.0604-0.0162-1.01[-1.10,1.07]0.7913840.96240873_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.