Metamoodics Gene Information

 

  Chromosome: chr9    Cytoband: p21.3    Gene: ELAVL2

 

BP - Genomewide Expression Studies for ELAVL2


 

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Description

 
Shown here are the results for gene ELAVL2 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.0956-0.0154-1.01[-1.15,1.13]0.8730.999208427_s_at
Harvard.FrontalFrontalHGU133A0.0957-0.0525-1.04[-1.18,1.1]0.5870.98208427_s_at
Harvard.HippHippocampusHGU95AV20.1298-0.2083-1.16[-1.38,1.03]0.1350.44336410_f_at
ChenFrontalBA46HGU133P0.07480.0285 1.02[-1.09,1.13]0.7060.965228260_at
DobrinFrontalBA46HGU133P0.05990.0844 1.06[-1.02,1.15]0.1660.948228260_at
KatoFrontalBA46HGU133A0.0523-2e-04-1[-1.07,1.07]0.9960.998208427_s_at
KemetherThalamusHGU133P0.0650.0459 1.03[-1.06,1.13]0.4880.885228260_at
LaengHippocampusHGU133P0.0588-0.1009-1.07[-1.16,1.01]0.09420.999228260_at
          
megaanalysisAny_BrainHGU1330.0272-0.0035-1[-1.04,1.04]0.8970.987 
megaanalysisFrontal_CortexHGU1330.03720.009 1.01[-1.05,1.06]0.8080.95311 
megaanalysisHippocampusHGU133&HGU950.0541-0.1288-1.09[-1.18,-1.02]0.02090.756 
 
* Additional studies not included in megaanalysis     
FeinbergCerebellumHGU95AV20.1004-0.1524-1.11[-1.27,1.03]0.1420610.89436410_f_at
KatoBFrontalBA10HGU95AV20.1145-0.0823-1.06[-1.24,1.10]0.4791580.8136410_f_at
SklarAFrontalBA8.9HGU95AV20.1078-0.0493-1.03[-1.20,1.12]0.65297136410_f_at
SklarBCerebellumHGU95AV20.0738-0.0408-1.03[-1.14,1.07]0.5870510.97836410_f_at
SokolovTemporal.CortexHGU95AV20.1336-0.2013-1.15[-1.38,1.04]0.1453880.76836410_f_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.