Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: p21.31    Gene: FKBP5

 

BP - Genomewide Expression Studies for FKBP5


 

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Description

 
Shown here are the results for gene FKBP5 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.08390.008 1.01[-1.11,1.13]0.9240.999204560_at
Harvard.HippHippocampusHGU95AV20.15960.0353 1.02[-1.21,1.27]0.8290.93434721_at
BahnFrontalBA46HGU133A0.06450.0226 1.02[-1.07,1.11]0.7270.951204560_at
ChenFrontalBA46HGU133P0.14560.2759 1.21[-1.01,1.48]0.06970.741224840_at
DobrinFrontalBA46HGU133P0.15650.5647 1.48[1.2,1.83]0.0007570.948224840_at
KatoFrontalBA46HGU133A0.0590.1397 1.1[1.02,1.19]0.02110.546204560_at
KemetherThalamusHGU133P0.25890.446 1.36[-1.04,1.94]0.09960.714224840_at
LaengHippocampusHGU133P0.08160.0762 1.05[-1.06,1.18]0.3560.999224840_at
          
megaanalysisAny_BrainHGU1330.050.1896 1.14[1.07,1.22]0.0001830.114 
megaanalysisFrontal_CortexHGU1330.05560.2236 1.17[1.08,1.26]8.27e-050.05661 
megaanalysisHippocampusHGU133&HGU950.07160.0656 1.05[-1.05,1.15]0.3640.987 
 
* Additional studies not included in megaanalysis     
FeinbergCerebellumHGU95AV20.06800.1069 1.08[-1.02,1.18]0.1290560.89434721_at
KatoBFrontalBA10HGU95AV20.06330.1142 1.08[-1.01,1.18]0.0837510.46834721_at
SklarAFrontalBA8.9HGU95AV20.12010.0140 1.01[-1.17,1.19]0.90842134721_at
SklarBCerebellumHGU95AV20.0978-0.1658-1.12[-1.28,1.02]0.1062870.97834721_at
SokolovTemporal.CortexHGU95AV20.11810.1839 1.14[-1.03,1.33]0.1332770.76634721_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.