Metamoodics Gene Information

 

  Chromosome: chr12    Cytoband: p13.31    Gene: GNB3

 

BP - Genomewide Expression Studies for GNB3


 

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Description

 
Shown here are the results for gene GNB3 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.0826-0.0462-1.03[-1.16,1.08]0.5790.999206047_at
Harvard.FrontalFrontalHGU133A0.02690.049 1.03[-1,1.07]0.07560.93206047_at
Harvard.HippHippocampusHGU95AV20.05360.0319 1.02[-1.05,1.1]0.5630.801225_at
AltarAFrontalBA46HGU133A0.0264-0.032-1.02[-1.06,1.01]0.2290.5791206047_at
BahnFrontalBA46HGU133A0.04180.0434 1.03[-1.03,1.09]0.3030.823206047_at
ChenFrontalBA46HGU133P0.0431-0.0344-1.02[-1.09,1.04]0.4330.904206047_at
DobrinFrontalBA46HGU133P0.04680.0162 1.01[-1.05,1.08]0.7320.989206047_at
KatoFrontalBA46HGU133A0.03950.0618 1.04[-1.01,1.1]0.1220.728206047_at
KemetherThalamusHGU133P0.0609-0.036-1.03[-1.11,1.06]0.5610.911206047_at
LaengHippocampusHGU133P0.0380.0272 1.02[-1.03,1.07]0.4790.999206047_at
          
megaanalysisAny_BrainHGU1330.01620.0114 1.01[-1.01,1.03]0.4830.902 
megaanalysisFrontal_CortexHGU1330.01710.0216 1.02[-1.01,1.04]0.2070.65555 
megaanalysisHippocampusHGU133&HGU950.03090.0284 1.02[-1.02,1.06]0.3620.987 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.06040.1574 1.12[1.03,1.21]0.01690.023246206047_at
FeinbergCerebellumHGU95AV20.03450.0358 1.03[-1.02,1.07]0.3095280.913225_at
KatoBFrontalBA10HGU95AV20.03000.0302 1.02[-1.02,1.06]0.3248290.719225_at
SklarAFrontalBA8.9HGU95AV20.03080.0020 1.00[-1.04,1.04]0.949231225_at
SklarBCerebellumHGU95AV20.06120.0173 1.01[-1.07,1.10]0.7803770.994225_at
SokolovTemporal.CortexHGU95AV20.0390-0.0055-1.00[-1.06,1.05]0.8893340.98225_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.