Metamoodics Gene Information

 

  Chromosome: chr3    Cytoband: p26.1    Gene: GRM7

 

BP - Genomewide Expression Studies for GRM7


 

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Description

 
Shown here are the results for gene GRM7 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.FrontalFrontalHGU133A0.0821-0.0171-1.01[-1.13,1.1]0.8360.986207548_at
Harvard.HippHippocampusHGU95AV20.0459-0.0545-1.04[-1.11,1.02]0.2580.5831585_at
AltarAFrontalBA46HGU133A0.04620.0202 1.01[-1.05,1.08]0.6630.8686207548_at
BahnFrontalBA46HGU133A0.05910.0799 1.06[-1.03,1.15]0.1820.75207548_at
ChenFrontalBA46HGU133P0.1108-0.1629-1.12[-1.3,1.04]0.1540.798207548_at
DobrinFrontalBA46HGU133P0.07860.0134 1.01[-1.1,1.12]0.8660.997207548_at
KatoFrontalBA46HGU133A0.0541-0.0171-1.01[-1.09,1.06]0.7530.961207548_at
KemetherThalamusHGU133P0.069-0.0099-1.01[-1.11,1.09]0.8870.983207548_at
LaengHippocampusHGU133P0.0447-0.0175-1.01[-1.08,1.05]0.6980.999207548_at
          
megaanalysisAny_BrainHGU1330.027-0.002-1[-1.04,1.04]0.9420.993 
megaanalysisFrontal_CortexHGU1330.0311-0.0017-1[-1.04,1.04]0.9560.99049 
megaanalysisHippocampusHGU133&HGU950.0348-0.0271-1.02[-1.07,1.03]0.4410.99 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.1156-0.4984-1.41[-1.65,-1.21]0.0003390.000666207548_at
FeinbergCerebellumHGU95AV20.0215-0.0523-1.04[-1.07,-1.01]0.0226920.89431585_at
KatoBFrontalBA10HGU95AV20.05070.0159 1.01[-1.06,1.08]0.7565360.92431585_at
SklarAFrontalBA8.9HGU95AV20.0841-0.1483-1.11[-1.24,1.01]0.09483131585_at
SklarBCerebellumHGU95AV20.08540.0201 1.01[-1.11,1.14]0.8165010.99531585_at
SokolovTemporal.CortexHGU95AV20.0477-0.0078-1.01[-1.07,1.06]0.8711390.97931585_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.