Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q25.3    Gene: HABP2

 

BP - Genomewide Expression Studies for HABP2


 

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Description

 
Shown here are the results for gene HABP2 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.05470.0616 1.04[-1.03,1.12]0.2670.999206010_at
Harvard.FrontalFrontalHGU133A0.0342-0.0286-1.02[-1.07,1.03]0.4080.96206010_at
Harvard.HippHippocampusHGU95AV20.04340.2113 1.16[1.09,1.23]0.0003850.196742_at
AltarAFrontalBA46HGU133A0.02550.0392 1.03[-1.01,1.06]0.1310.4535206010_at
BahnFrontalBA46HGU133A0.0321-0.0417-1.03[-1.08,1.01]0.1990.763206010_at
ChenFrontalBA46HGU133P0.04770.0073 1.01[-1.06,1.07]0.8790.985206010_at
DobrinFrontalBA46HGU133P0.0640.0282 1.02[-1.07,1.11]0.6620.982206010_at
KatoFrontalBA46HGU133A0.03580.0093 1.01[-1.04,1.06]0.7960.969206010_at
          
megaanalysisAny_BrainHGU1330.01550.0084 1.01[-1.02,1.03]0.5890.931 
megaanalysisFrontal_CortexHGU1330.01610.0023 1[-1.02,1.02]0.8880.97287 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.04510.2524 1.19[1.12,1.27]1.77e-055.54e-05206010_at
FeinbergCerebellumHGU95AV20.0372-0.0284-1.02[-1.07,1.03]0.4524730.933742_at
KatoBFrontalBA10HGU95AV20.0328-0.0195-1.01[-1.06,1.03]0.5579750.845742_at
SklarAFrontalBA8.9HGU95AV20.0811-0.0408-1.03[-1.15,1.09]0.621161742_at
SklarBCerebellumHGU95AV20.0714-0.1347-1.10[-1.21,1.00]0.0746600.978742_at
SokolovTemporal.CortexHGU95AV20.05050.1500 1.11[1.04,1.19]0.0068520.759742_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.