Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q23.31    Gene: HTR7

 

BP - Genomewide Expression Studies for HTR7


 

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Description

 
Shown here are the results for gene HTR7 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.HippHippocampusHGU95AV20.08530.0031 1[-1.12,1.13]0.9720.99134634_s_at
KemetherThalamusHGU133P0.1267-0.2461-1.19[-1.41,1]0.06560.702236281_x_at
          
 
* Additional studies not included in megaanalysis     
FeinbergCerebellumHGU95AV20.03380.0393 1.03[-1.02,1.08]0.2573200.91234634_s_at
KatoBFrontalBA10HGU95AV20.04870.1005 1.07[1.00,1.15]0.0500550.39534634_s_at
SklarAFrontalBA8.9HGU95AV20.0755-0.0406-1.03[-1.14,1.08]0.59755134634_s_at
SklarBCerebellumHGU95AV20.08950.0197 1.01[-1.11,1.14]0.8280860.99534634_s_at
SokolovTemporal.CortexHGU95AV20.04660.0556 1.04[-1.03,1.11]0.2456880.78734634_s_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.