Metamoodics Gene Information

 

  Chromosome: chrX    Cytoband: p11.3    Gene: MAOA

 

BP - Genomewide Expression Studies for MAOA


 

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Description

 
Shown here are the results for gene MAOA from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.06940.076 1.05[-1.04,1.16]0.2820.999212741_at
Harvard.FrontalFrontalHGU133A0.062-0.0783-1.06[-1.15,1.03]0.2140.94212741_at
Harvard.HippHippocampusHGU95AV20.0863-0.0614-1.04[-1.17,1.08]0.490.75541771_g_at
AltarAFrontalBA46HGU133A0.05020.1832 1.14[1.06,1.22]0.0005570.0496212741_at
BahnFrontalBA46HGU133A0.05490.1336 1.1[1.02,1.18]0.0180.517212741_at
ChenFrontalBA46HGU133P0.05520.1296 1.09[1.01,1.18]0.02720.699212741_at
DobrinFrontalBA46HGU133P0.07520.2302 1.17[1.06,1.3]0.003670.948212741_at
KatoFrontalBA46HGU133A0.05830.1137 1.08[-1,1.17]0.05590.641212741_at
KemetherThalamusHGU133P0.09610.0417 1.03[-1.11,1.17]0.6680.932212741_at
LaengHippocampusHGU133P0.0390.0514 1.04[-1.02,1.09]0.1950.999212741_at
          
megaanalysisAny_BrainHGU1330.02690.0909 1.07[1.03,1.1]0.000810.182 
megaanalysisFrontal_CortexHGU1330.03140.098 1.07[1.03,1.12]0.001990.12885 
megaanalysisHippocampusHGU133&HGU950.03630.0221 1.02[-1.03,1.07]0.5440.991 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.0529-0.4288-1.35[-1.45,-1.25]9.49e-082.04e-06212741_at
FeinbergCerebellumHGU95AV20.0356-0.0222-1.02[-1.07,1.03]0.5374410.9541771_g_at
KatoBFrontalBA10HGU95AV20.0491-0.0305-1.02[-1.09,1.05]0.5396980.83841771_g_at
SklarAFrontalBA8.9HGU95AV20.08750.2100 1.16[1.03,1.30]0.02738141771_g_at
SklarBCerebellumHGU95AV20.05840.0956 1.07[-1.01,1.16]0.1179200.97841771_g_at
SokolovTemporal.CortexHGU95AV20.10310.0879 1.06[-1.08,1.22]0.4029740.85141771_g_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.