Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q23.3    Gene: MAP3K5

 

BP - Genomewide Expression Studies for MAP3K5


 

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Description

 
Shown here are the results for gene MAP3K5 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.0671-0.0461-1.03[-1.13,1.06]0.4970.999203837_at
Harvard.FrontalFrontalHGU133A0.0484-0.0997-1.07[-1.14,-1]0.04570.93203837_at
Harvard.HippHippocampusHGU95AV20.0449-0.0108-1.01[-1.07,1.05]0.8140.9281327_s_at
AltarAFrontalBA46HGU133A0.03640.0698 1.05[-1,1.1]0.05990.3206203837_at
BahnFrontalBA46HGU133A0.0501-0.078-1.06[-1.13,1.01]0.1250.688203837_at
ChenFrontalBA46HGU133P0.0739-0.0858-1.06[-1.17,1.04]0.2560.839203837_at
DobrinFrontalBA46HGU133P0.06050.067 1.05[-1.04,1.14]0.2740.958203837_at
KatoFrontalBA46HGU133A0.0499-0.0156-1.01[-1.08,1.06]0.7560.962203837_at
KemetherThalamusHGU133P0.0814-0.0896-1.06[-1.19,1.05]0.2840.822203837_at
LaengHippocampusHGU133P0.04360.0543 1.04[-1.02,1.1]0.220.999203837_at
          
megaanalysisAny_BrainHGU1330.02-0.021-1.01[-1.04,1.01]0.2940.828 
megaanalysisFrontal_CortexHGU1330.023-0.0215-1.02[-1.05,1.02]0.350.77211 
megaanalysisHippocampusHGU133&HGU950.03410.0374 1.03[-1.02,1.08]0.2780.987 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.0964-0.7562-1.69[-1.93,-1.48]1.57e-072.54e-06203837_at
FeinbergCerebellumHGU95AV20.0662-0.0431-1.03[-1.13,1.06]0.5209590.9451327_s_at
KatoBFrontalBA10HGU95AV20.0540-0.0724-1.05[-1.13,1.02]0.1927100.6071327_s_at
SklarAFrontalBA8.9HGU95AV20.10050.0445 1.03[-1.11,1.18]0.6630611327_s_at
SklarBCerebellumHGU95AV20.1523-0.0945-1.07[-1.31,1.15]0.5423610.9781327_s_at
SokolovTemporal.CortexHGU95AV20.0888-0.0331-1.02[-1.15,1.10]0.7123460.9461327_s_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.