Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT1E

 

BP - Genomewide Expression Studies for MT1E


 

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Description

 
Shown here are the results for gene MT1E from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.12130.0569 1.04[-1.13,1.23]0.6420.999212859_x_at
Harvard.FrontalFrontalHGU133A0.0873-0.105-1.08[-1.21,1.05]0.2360.94212859_x_at
Harvard.HippHippocampusHGU95AV20.1389-0.023-1.02[-1.23,1.19]0.8710.9536130_f_at
AltarAFrontalBA46HGU133A0.08830.3095 1.24[1.1,1.4]0.0008790.0573212859_x_at
BahnFrontalBA46HGU133A0.10150.2018 1.15[1,1.32]0.05140.612212859_x_at
ChenFrontalBA46HGU133P0.10320.4071 1.33[1.15,1.53]0.0005720.42212859_x_at
DobrinFrontalBA46HGU133P0.11090.2765 1.21[1.04,1.41]0.01630.948212859_x_at
KatoFrontalBA46HGU133A0.08610.2165 1.16[1.03,1.31]0.01460.53212859_x_at
KemetherThalamusHGU133P0.08690.115 1.08[-1.04,1.22]0.20.793212859_x_at
LaengHippocampusHGU133P0.08690.1614 1.12[-1.01,1.26]0.07110.999212859_x_at
          
megaanalysisAny_BrainHGU1330.04620.1544 1.11[1.05,1.18]0.0009030.183 
megaanalysisFrontal_CortexHGU1330.05370.1799 1.13[1.05,1.22]0.0009180.08454 
megaanalysisHippocampusHGU133&HGU950.07330.1136 1.08[-1.02,1.2]0.1270.938 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.09390.2681 1.2[1.06,1.37]0.00980.014034212859_x_at
FeinbergCerebellumHGU95AV20.12790.1558 1.11[-1.07,1.33]0.2351780.9136130_f_at
KatoBFrontalBA10HGU95AV20.10310.3046 1.24[1.07,1.42]0.0069140.25736130_f_at
SklarAFrontalBA8.9HGU95AV20.16600.4235 1.34[1.07,1.68]0.02004136130_f_at
SklarBCerebellumHGU95AV20.11870.1882 1.14[-1.03,1.34]0.1291570.97836130_f_at
SokolovTemporal.CortexHGU95AV20.11000.3374 1.26[1.09,1.47]0.0054550.75836130_f_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.