Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT1G

 

BP - Genomewide Expression Studies for MT1G


 

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Description

 
Shown here are the results for gene MT1G from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.10240.2189 1.16[1.01,1.34]0.03980.999204745_x_at
Harvard.FrontalFrontalHGU133A0.0872-0.02-1.01[-1.14,1.11]0.820.985204745_x_at
Harvard.HippHippocampusHGU95AV20.2857-0.1121-1.08[-1.59,1.36]0.7020.872926_at
AltarAFrontalBA46HGU133A0.08230.1749 1.13[1.01,1.26]0.03770.2654204745_x_at
BahnFrontalBA46HGU133A0.07980.1556 1.11[-1,1.24]0.05580.625204745_x_at
ChenFrontalBA46HGU133P0.10610.2458 1.19[1.03,1.37]0.02890.699204745_x_at
DobrinFrontalBA46HGU133P0.09630.2201 1.16[1.02,1.33]0.02690.948204745_x_at
KatoFrontalBA46HGU133A0.08010.1551 1.11[-1,1.24]0.05740.642204745_x_at
KemetherThalamusHGU133P0.07770.0322 1.02[-1.09,1.14]0.6830.936204745_x_at
LaengHippocampusHGU133P0.07250.1261 1.09[-1.01,1.2]0.08990.999204745_x_at
          
megaanalysisAny_BrainHGU1330.04090.1301 1.09[1.04,1.16]0.001580.197 
megaanalysisFrontal_CortexHGU1330.0480.1311 1.1[1.03,1.17]0.006690.20951 
megaanalysisHippocampusHGU133&HGU950.08910.0643 1.05[-1.08,1.18]0.4730.991 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.080.1107 1.08[-1.03,1.2]0.1820.212269204745_x_at
FeinbergCerebellumHGU95AV20.0389-0.0222-1.02[-1.07,1.04]0.5739810.955926_at
KatoBFrontalBA10HGU95AV20.13370.0994 1.07[-1.12,1.28]0.4641230.801926_at
SklarAFrontalBA8.9HGU95AV20.08760.1525 1.11[-1.01,1.25]0.098861926_at
SklarBCerebellumHGU95AV20.12480.1921 1.14[-1.04,1.35]0.1402190.978926_at
SokolovTemporal.CortexHGU95AV20.14160.2389 1.18[-1.03,1.43]0.1051320.759926_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.