Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT1X

 

BP - Genomewide Expression Studies for MT1X


 

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Description

 
Shown here are the results for gene MT1X from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.14510.1738 1.13[-1.08,1.37]0.2390.999204326_x_at
Harvard.FrontalFrontalHGU133A0.1082-0.1187-1.09[-1.26,1.07]0.2790.944204326_x_at
Harvard.HippHippocampusHGU95AV20.25230.0323 1.02[-1.38,1.44]0.90.96439120_at
AltarAFrontalBA46HGU133A0.13920.5036 1.42[1.17,1.71]0.0006190.0516204326_x_at
BahnFrontalBA46HGU133A0.15890.229 1.17[-1.06,1.45]0.1550.716204326_x_at
ChenFrontalBA46HGU133P0.13230.3703 1.29[1.08,1.55]0.009720.631204326_x_at
DobrinFrontalBA46HGU133P0.12340.4164 1.33[1.13,1.58]0.001510.948204326_x_at
KatoFrontalBA46HGU133A0.1310.3016 1.23[1.03,1.47]0.02480.559204326_x_at
KemetherThalamusHGU133P0.11980.0671 1.05[-1.12,1.23]0.5810.916204326_x_at
LaengHippocampusHGU133P0.09730.096 1.07[-1.07,1.22]0.330.999204326_x_at
          
megaanalysisAny_BrainHGU1330.06340.2011 1.15[1.05,1.25]0.001620.197 
megaanalysisFrontal_CortexHGU1330.07490.2335 1.18[1.06,1.3]0.001990.12885 
megaanalysisHippocampusHGU133&HGU950.09460.0795 1.06[-1.08,1.2]0.4040.99 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.12140.0132 1.01[-1.17,1.19]0.9150.925571204326_x_at
FeinbergCerebellumHGU95AV20.18670.1684 1.12[-1.15,1.45]0.3760100.91639120_at
KatoBFrontalBA10HGU95AV20.16460.5875 1.50[1.20,1.88]0.0015480.21739120_at
SklarAFrontalBA8.9HGU95AV20.18970.2234 1.17[-1.11,1.51]0.25438139120_at
SklarBCerebellumHGU95AV20.15010.1695 1.12[-1.09,1.38]0.2726680.97839120_at
SokolovTemporal.CortexHGU95AV20.19990.3675 1.29[-1.02,1.69]0.0790340.75939120_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.