Shown here are the results for gene MT2A from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

 

STUDY	BRAIN_REGION	ARRAY_PLATFORM	SE	BETA_EST.	FC	95%_CI	PVAL	FDR_PVAL	PROBESET
Harvard.CC	CingularCortex	HGU133A	0.1266	0.1707	1.13	[-1.06,1.34]	0.187	0.999	212185_x_at
Harvard.Frontal	Frontal	HGU133A	0.0874	-0.0886	-1.06	[-1.2,1.06]	0.317	0.953	212185_x_at
Harvard.Hipp	Hippocampus	HGU95AV2	0.1273	0.1742	1.13	[-1.05,1.34]	0.196	0.514	39081_at
AltarA	FrontalBA46	HGU133A	0.0883	0.2882	1.22	[1.08,1.38]	0.00183	0.0752	212185_x_at
Bahn	FrontalBA46	HGU133A	0.0944	0.1749	1.13	[-1.01,1.28]	0.0687	0.639	212185_x_at
Chen	FrontalBA46	HGU133P	0.1281	0.3174	1.25	[1.05,1.48]	0.0204	0.677	212185_x_at
Dobrin	FrontalBA46	HGU133P	0.1165	0.2713	1.21	[1.03,1.41]	0.0243	0.948	212185_x_at
Kato	FrontalBA46	HGU133A	0.0848	0.2239	1.17	[1.04,1.31]	0.0105	0.5	212185_x_at
Kemether	Thalamus	HGU133P	0.0801	0.0889	1.06	[-1.05,1.19]	0.28	0.821	212185_x_at
Laeng	Hippocampus	HGU133P	0.0732	0.1408	1.1	[-1,1.22]	0.0619	0.999	212185_x_at
megaanalysis	Any_Brain	HGU133	0.0456	0.1511	1.11	[1.04,1.18]	0.000992	0.183
megaanalysis	Frontal_Cortex	HGU133	0.0534	0.163	1.12	[1.04,1.2]	0.00247	0.13762
megaanalysis	Hippocampus	HGU133&HGU95	0.0622	0.1495	1.11	[1.02,1.21]	0.0199	0.756
* Additional studies not included in megaanalysis
AltarC	FrontalBA46.10	HGU133A	0.11	0.2909	1.22	[1.05,1.42]	0.0155	0.021447	212185_x_at
Feinberg	Cerebellum	HGU95AV2	0.2110	0.1672	1.12	[-1.19,1.50]	0.435945	0.926	39081_at
KatoB	FrontalBA10	HGU95AV2	0.1518	0.1614	1.12	[-1.10,1.37]	0.298389	0.704	39081_at
SklarA	FrontalBA8.9	HGU95AV2	0.2825	0.7497	1.68	[1.15,2.47]	0.01615	1	39081_at
SklarB	Cerebellum	HGU95AV2	0.2003	0.3594	1.28	[-1.02,1.68]	0.088704	0.978	39081_at
Sokolov	Temporal.Cortex	HGU95AV2	0.1589	0.0118	1.01	[-1.23,1.25]	0.941356	0.991	39081_at

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.