Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT2A

 

BP - Genomewide Expression Studies for MT2A


 

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Description

 
Shown here are the results for gene MT2A from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.12660.1707 1.13[-1.06,1.34]0.1870.999212185_x_at
Harvard.FrontalFrontalHGU133A0.0874-0.0886-1.06[-1.2,1.06]0.3170.953212185_x_at
Harvard.HippHippocampusHGU95AV20.12730.1742 1.13[-1.05,1.34]0.1960.51439081_at
AltarAFrontalBA46HGU133A0.08830.2882 1.22[1.08,1.38]0.001830.0752212185_x_at
BahnFrontalBA46HGU133A0.09440.1749 1.13[-1.01,1.28]0.06870.639212185_x_at
ChenFrontalBA46HGU133P0.12810.3174 1.25[1.05,1.48]0.02040.677212185_x_at
DobrinFrontalBA46HGU133P0.11650.2713 1.21[1.03,1.41]0.02430.948212185_x_at
KatoFrontalBA46HGU133A0.08480.2239 1.17[1.04,1.31]0.01050.5212185_x_at
KemetherThalamusHGU133P0.08010.0889 1.06[-1.05,1.19]0.280.821212185_x_at
LaengHippocampusHGU133P0.07320.1408 1.1[-1,1.22]0.06190.999212185_x_at
          
megaanalysisAny_BrainHGU1330.04560.1511 1.11[1.04,1.18]0.0009920.183 
megaanalysisFrontal_CortexHGU1330.05340.163 1.12[1.04,1.2]0.002470.13762 
megaanalysisHippocampusHGU133&HGU950.06220.1495 1.11[1.02,1.21]0.01990.756 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.110.2909 1.22[1.05,1.42]0.01550.021447212185_x_at
FeinbergCerebellumHGU95AV20.21100.1672 1.12[-1.19,1.50]0.4359450.92639081_at
KatoBFrontalBA10HGU95AV20.15180.1614 1.12[-1.10,1.37]0.2983890.70439081_at
SklarAFrontalBA8.9HGU95AV20.28250.7497 1.68[1.15,2.47]0.01615139081_at
SklarBCerebellumHGU95AV20.20030.3594 1.28[-1.02,1.68]0.0887040.97839081_at
SokolovTemporal.CortexHGU95AV20.15890.0118 1.01[-1.23,1.25]0.9413560.99139081_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.