Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q14.1    Gene: MYO6

 

BP - Genomewide Expression Studies for MYO6


 

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Description

 
Shown here are the results for gene MYO6 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.0834-0.2155-1.16[-1.3,-1.04]0.01430.999203216_s_at
Harvard.FrontalFrontalHGU133A0.0796-0.0054-1[-1.12,1.11]0.9460.997203216_s_at
Harvard.HippHippocampusHGU95AV20.04430.0617 1.04[-1.02,1.11]0.1890.50733375_at
AltarAFrontalBA46HGU133A0.05540.0082 1.01[-1.07,1.08]0.8830.962203216_s_at
BahnFrontalBA46HGU133A0.0653-0.0425-1.03[-1.13,1.06]0.5170.9203216_s_at
ChenFrontalBA46HGU133P0.07580.0699 1.05[-1.06,1.16]0.3650.883203216_s_at
DobrinFrontalBA46HGU133P0.05720.0766 1.05[-1.02,1.14]0.1870.952203216_s_at
KatoFrontalBA46HGU133A0.06360.1283 1.09[1,1.19]0.04820.625203216_s_at
KemetherThalamusHGU133P0.068-0.0637-1.05[-1.15,1.05]0.3590.836203216_s_at
LaengHippocampusHGU133P0.03870.0157 1.01[-1.04,1.07]0.6870.999203216_s_at
          
megaanalysisAny_BrainHGU1330.0285-0.0059-1[-1.04,1.04]0.8350.977 
megaanalysisFrontal_CortexHGU1330.03170.0344 1.02[-1.02,1.07]0.2780.71461 
megaanalysisHippocampusHGU133&HGU950.03060.0276 1.02[-1.02,1.06]0.370.989 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.123-0.3822-1.3[-1.54,-1.1]0.005540.008287203216_s_at
FeinbergCerebellumHGU95AV20.02590.0150 1.01[-1.03,1.05]0.5691160.95533375_at
KatoBFrontalBA10HGU95AV20.04550.0909 1.07[1.00,1.13]0.0572090.41833375_at
SklarAFrontalBA8.9HGU95AV20.0713-0.0382-1.03[-1.13,1.07]0.59850133375_at
SklarBCerebellumHGU95AV20.07920.1541 1.11[-1.00,1.24]0.0665670.97833375_at
SokolovTemporal.CortexHGU95AV20.0648-0.0186-1.01[-1.11,1.08]0.7769490.9633375_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.