Metamoodics Gene Information

 

  Chromosome: chr7    Cytoband: p15.3    Gene: NPY

 

BP - Genomewide Expression Studies for NPY


 

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Description

 
Shown here are the results for gene NPY from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.1341-0.2202-1.16[-1.4,1.03]0.110.999206001_at
Harvard.FrontalFrontalHGU133A0.1560.0683 1.05[-1.18,1.3]0.6640.983206001_at
Harvard.HippHippocampusHGU95AV20.1968-0.2407-1.18[-1.54,1.11]0.2450.56538604_at
AltarAFrontalBA46HGU133A0.1-0.259-1.2[-1.37,-1.04]0.01210.1713206001_at
BahnFrontalBA46HGU133A0.1066-0.1909-1.14[-1.32,1.01]0.07840.641206001_at
ChenFrontalBA46HGU133P0.1673-0.2613-1.2[-1.5,1.05]0.1310.781206001_at
DobrinFrontalBA46HGU133P0.1332-0.2977-1.23[-1.47,-1.03]0.03040.948206001_at
KatoFrontalBA46HGU133A0.1158-0.1841-1.14[-1.33,1.03]0.1170.724206001_at
LaengHippocampusHGU133P0.175-0.0391-1.03[-1.3,1.23]0.8250.999206001_at
          
megaanalysisAny_BrainHGU1330.064-0.1641-1.12[-1.22,-1.03]0.01070.369 
megaanalysisFrontal_CortexHGU1330.0711-0.1585-1.12[-1.23,-1.01]0.02670.33343 
megaanalysisHippocampusHGU133&HGU950.138-0.0914-1.07[-1.29,1.13]0.5110.991 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.1997-1.104-2.15[-2.82,-1.64]2.06e-056.21e-05206001_at
FeinbergCerebellumHGU95AV20.03090.0345 1.02[-1.02,1.07]0.2748940.91338604_at
KatoBFrontalBA10HGU95AV20.1408-0.0065-1.00[-1.22,1.21]0.9637750.99138604_at
SklarAFrontalBA8.9HGU95AV20.1375-0.4148-1.33[-1.61,-1.11]0.00741138604_at
SklarBCerebellumHGU95AV20.0592-0.0063-1.00[-1.09,1.08]0.9162150.99738604_at
SokolovTemporal.CortexHGU95AV20.1430-0.0288-1.02[-1.24,1.19]0.8420470.97338604_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.