Metamoodics Gene Information

 

  Chromosome: chr11    Cytoband: q14.1    Gene: ODZ4

 

BP - Genomewide Expression Studies for ODZ4


 

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Description

 
Shown here are the results for gene ODZ4 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.07330.053 1.04[-1.06,1.15]0.4750.999213273_at
Harvard.FrontalFrontalHGU133A0.05370.0324 1.02[-1.05,1.1]0.550.973213273_at
Harvard.HippHippocampusHGU95AV20.12770.1241 1.09[-1.09,1.3]0.350.65836078_at
AltarAFrontalBA46HGU133A0.03050.0344 1.02[-1.02,1.07]0.2640.6095213273_at
BahnFrontalBA46HGU133A0.04380.0165 1.01[-1.05,1.07]0.7070.944213273_at
ChenFrontalBA46HGU133P0.048-0.0157-1.01[-1.08,1.06]0.7450.972213273_at
DobrinFrontalBA46HGU133P0.05580.077 1.05[-1.02,1.14]0.1740.949213273_at
KatoFrontalBA46HGU133A0.04210.0298 1.02[-1.04,1.08]0.4820.905213273_at
KemetherThalamusHGU133P0.0683-0.1993-1.15[-1.26,-1.05]0.008210.701213273_at
LaengHippocampusHGU133P0.04260.0138 1.01[-1.05,1.07]0.7480.999213273_at
          
megaanalysisAny_BrainHGU1330.02080.0154 1.01[-1.02,1.04]0.4590.891 
megaanalysisFrontal_CortexHGU1330.02280.0294 1.02[-1.01,1.05]0.1980.64693 
megaanalysisHippocampusHGU133&HGU950.04470.0424 1.03[-1.03,1.09]0.3480.987 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.0653-0.29-1.22[-1.34,-1.12]0.000250.00051213273_at
FeinbergCerebellumHGU95AV20.0411-0.0052-1.00[-1.06,1.05]0.8999240.9936078_at
KatoBFrontalBA10HGU95AV20.06400.0473 1.03[-1.06,1.13]0.4670020.80336078_at
SklarAFrontalBA8.9HGU95AV20.08130.0010 1.00[-1.12,1.12]0.99012136078_at
SklarBCerebellumHGU95AV20.04920.0061 1.00[-1.06,1.07]0.9019680.99736078_at
SokolovTemporal.CortexHGU95AV20.0829-0.1513-1.11[-1.24,1.01]0.0808300.75936078_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.