Metamoodics Gene Information

 

  Chromosome: chr7    Cytoband: q22.1    Gene: RELN

 

BP - Genomewide Expression Studies for RELN


 

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Description

 
Shown here are the results for gene RELN from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.0826-0.0226-1.02[-1.14,1.1]0.7860.999205923_at
Harvard.FrontalFrontalHGU133A0.1123-0.0045-1[-1.17,1.16]0.9680.997205923_at
Harvard.HippHippocampusHGU95AV20.1018-0.0716-1.05[-1.21,1.09]0.4950.75737530_s_at
AltarAFrontalBA46HGU133A0.0678-0.1281-1.09[-1.2,1]0.06390.3291205923_at
BahnFrontalBA46HGU133A0.0824-0.1721-1.13[-1.26,-1.01]0.04110.581205923_at
ChenFrontalBA46HGU133P0.1419-0.087-1.06[-1.29,1.14]0.5450.933205923_at
DobrinFrontalBA46HGU133P0.0811-0.142-1.1[-1.23,1.01]0.08650.948205923_at
KatoFrontalBA46HGU133A0.0677-0.1083-1.08[-1.18,1.02]0.1150.724205923_at
KemetherThalamusHGU133P0.1664-0.1115-1.08[-1.35,1.16]0.510.891205923_at
LaengHippocampusHGU133P0.0993-0.1809-1.13[-1.3,1.01]0.07650.999205923_at
          
megaanalysisAny_BrainHGU1330.0425-0.0923-1.07[-1.13,-1.01]0.03040.479 
megaanalysisFrontal_CortexHGU1330.0501-0.0948-1.07[-1.14,1]0.05940.43686 
megaanalysisHippocampusHGU133&HGU950.0775-0.1526-1.11[-1.23,-1]0.05430.877 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.1449-0.2301-1.17[-1.43,1.04]0.1280.153105205923_at
FeinbergCerebellumHGU95AV20.0584-0.0446-1.03[-1.12,1.05]0.4522250.93337530_s_at
KatoBFrontalBA10HGU95AV20.1216-0.0688-1.05[-1.24,1.12]0.5767730.85337530_s_at
SklarAFrontalBA8.9HGU95AV20.0945-0.0138-1.01[-1.15,1.13]0.88553137530_s_at
SklarBCerebellumHGU95AV20.1190-0.0991-1.07[-1.26,1.10]0.4149040.97837530_s_at
SokolovTemporal.CortexHGU95AV20.10690.1435 1.10[-1.05,1.28]0.1927730.77937530_s_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.