Metamoodics Gene Information

 

  Chromosome: chr17    Cytoband: q11.2    Gene: SLC6A4

 

BP - Genomewide Expression Studies for SLC6A4


 

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Description

 
Shown here are the results for gene SLC6A4 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.08640.0205 1.01[-1.11,1.14]0.8140.999207519_at
Harvard.FrontalFrontalHGU133A0.0424-0.0074-1.01[-1.06,1.05]0.8620.988207519_at
Harvard.HippHippocampusHGU95AV20.05340.0151 1.01[-1.06,1.09]0.7830.91434604_at
AltarAFrontalBA46HGU133A0.0299-0.0201-1.01[-1.06,1.03]0.5050.7829207519_at
BahnFrontalBA46HGU133A0.03470.0109 1.01[-1.04,1.06]0.7550.956207519_at
KatoFrontalBA46HGU133A0.03780.0187 1.01[-1.04,1.07]0.6230.941207519_at
          
megaanalysisAny_BrainHGU1330.0190.0038 1[-1.02,1.03]0.8420.978 
megaanalysisFrontal_CortexHGU1330.01770.0013 1[-1.02,1.03]0.9440.98675 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.07360.491 1.41[1.27,1.55]1.71e-061e-05207519_at
FeinbergCerebellumHGU95AV20.0303-0.0069-1.00[-1.05,1.04]0.8220070.98234604_at
KatoBFrontalBA10HGU95AV20.0402-0.0389-1.03[-1.09,1.03]0.3432040.72834604_at
SklarAFrontalBA8.9HGU95AV20.0877-0.0111-1.01[-1.14,1.12]0.90064134604_at
SklarBCerebellumHGU95AV20.09510.0373 1.03[-1.11,1.17]0.6996180.9934604_at
SokolovTemporal.CortexHGU95AV20.0514-0.0091-1.01[-1.08,1.07]0.8613680.97734604_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.