Metamoodics Gene Information

 

  Chromosome: chr3    Cytoband: q27.3    Gene: SST

 

BP - Genomewide Expression Studies for SST


 

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Description

 
Shown here are the results for gene SST from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.1652-0.2014-1.15[-1.44,1.09]0.2310.999213921_at
Harvard.FrontalFrontalHGU133A0.210.0988 1.07[-1.24,1.42]0.640.982213921_at
Harvard.HippHippocampusHGU95AV20.2895-0.8047-1.75[-2.59,-1.18]0.01670.2337782_at
AltarAFrontalBA46HGU133A0.1505-0.4696-1.38[-1.7,-1.13]0.00280.0899213921_at
BahnFrontalBA46HGU133A0.1348-0.4197-1.34[-1.61,-1.11]0.002830.467213921_at
ChenFrontalBA46HGU133P0.2559-0.444-1.36[-1.93,1.04]0.0950.779213921_at
DobrinFrontalBA46HGU133P0.173-0.4708-1.39[-1.75,-1.1]0.009160.948213921_at
KatoFrontalBA46HGU133A0.1373-0.4729-1.39[-1.67,-1.15]0.001050.355213921_at
KemetherThalamusHGU133P0.5449-0.4905-1.4[-2.95,1.49]0.3780.846213921_at
LaengHippocampusHGU133P0.1639-0.3442-1.27[-1.59,-1.02]0.04240.999213921_at
          
megaanalysisAny_BrainHGU1330.0927-0.3092-1.24[-1.41,-1.09]0.000930.183 
megaanalysisFrontal_CortexHGU1330.0973-0.302-1.23[-1.41,-1.08]0.00210.13068 
megaanalysisHippocampusHGU133&HGU950.1426-0.4636-1.38[-1.67,-1.14]0.002020.756 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.2731-1.3567-2.56[-3.71,-1.77]7.42e-050.000178213921_at
FeinbergCerebellumHGU95AV20.0299-0.0148-1.01[-1.05,1.03]0.6253980.9637782_at
KatoBFrontalBA10HGU95AV20.1817-0.4017-1.32[-1.69,-1.03]0.0368450.37137782_at
SklarAFrontalBA8.9HGU95AV20.2259-0.6628-1.58[-2.15,-1.16]0.00886137782_at
SklarBCerebellumHGU95AV20.05790.0292 1.02[-1.06,1.10]0.6201540.98137782_at
SokolovTemporal.CortexHGU95AV20.14160.0827 1.06[-1.14,1.28]0.5647920.91237782_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.