Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q25.1-q25.2    Gene: SYNE1

 

BP - Genomewide Expression Studies for SYNE1


 

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Description

 
Shown here are the results for gene SYNE1 from a meta-analysis of genomewide expression studies of bipolar disorder using microarrays with autopsy brain samples from humans. Details of the methods for carrying out the meta-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: The figure shows a Forest Plot with the estimated fold change of gene expression comparing cases and controls and 95% confidence interval for each study. Summary estimates are provided for all studies, studies with samples from the pre-frontal cortex, studies with samples specifically from BA46 of the pre-frontal cortex, and from the hippocampus. Details of the results are provided in the Results Table below.

 

 

Results Table

 

 

 

STUDYBRAIN_REGIONARRAY_PLATFORMSEBETA_EST.FC95%_CIPVALFDR_PVALPROBESET
Harvard.CCCingularCortexHGU133A0.0865-0.0101-1.01[-1.13,1.12]0.9080.999209447_at
Harvard.FrontalFrontalHGU133A0.087-0.0806-1.06[-1.19,1.06]0.3590.96209447_at
Harvard.HippHippocampusHGU95AV20.1109-0.0015-1[-1.16,1.16]0.990.99738113_at
AltarAFrontalBA46HGU133A0.04210.0787 1.06[-1,1.12]0.06640.3329209447_at
BahnFrontalBA46HGU133A0.05340.1563 1.11[1.04,1.2]0.004850.517209447_at
ChenFrontalBA46HGU133P0.11310.0502 1.04[-1.13,1.21]0.6610.96209447_at
DobrinFrontalBA46HGU133P0.08020.1788 1.13[1.02,1.26]0.03070.948209447_at
KatoFrontalBA46HGU133A0.0370.0781 1.06[1,1.11]0.03890.594209447_at
KemetherThalamusHGU133P0.0652-0.144-1.1[-1.21,-1.01]0.03850.701209447_at
LaengHippocampusHGU133P0.04440.0709 1.05[-1.01,1.12]0.1180.999209447_at
          
megaanalysisAny_BrainHGU1330.02830.0442 1.03[-1.01,1.07]0.1190.655 
megaanalysisFrontal_CortexHGU1330.03320.0645 1.05[-1,1.09]0.05330.42074 
megaanalysisHippocampusHGU133&HGU950.04270.0521 1.04[-1.02,1.1]0.2270.98 
 
* Additional studies not included in megaanalysis     
AltarCFrontalBA46.10HGU133A0.06490.1765 1.13[1.03,1.23]0.01320.018472209447_at
FeinbergCerebellumHGU95AV20.0924-0.0370-1.03[-1.16,1.10]0.6922450.97138113_at
KatoBFrontalBA10HGU95AV20.0555-0.0036-1.00[-1.08,1.08]0.9482460.98738113_at
SklarAFrontalBA8.9HGU95AV20.08600.1188 1.09[-1.04,1.22]0.18442138113_at
SklarBCerebellumHGU95AV20.07230.2353 1.18[1.07,1.30]0.0041460.97838113_at
SokolovTemporal.CortexHGU95AV20.0918-0.1012-1.07[-1.22,1.06]0.2816240.80538113_at

 

 

References

 

Systematic Review of Genome-wide Gene Expression Studies of Bipolar Disorder Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T. Judy, Fernando S. Goes, James B. Potash and Peter P. Zandi. Manuscript submitted.