Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: p13.3    Gene: ADCY9

 

BP - Genomewide Association Studies for ADCY9


 

View in Genome Browser

 

Description

 
Shown here are the results for gene ADCY9 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
Download:
   
Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
16rs80470384051526AG0.91641.06280.02801.52797530229972(Index SNP)
16rs7314714076158AG0.96101.05200.02401.461175011062100.46809
16rs3840674084812AC0.96680.94790.02541.458920232223370.54253
16rs4426114086696AG0.95380.94810.02551.437350327788080.54961
16rs110768084110105CG0.96071.05140.02491.360015751958410.14388
16rs3872124076419CT0.96151.05150.02541.323306390375130.569
16rs3884304075563CT0.95730.95110.02541.315423912611540.54253
16rs133380874044513GT0.92441.05010.02501.300509154727800.07596
16rs3992184091588CT0.96381.04700.02551.14393604666690.56897
16rs25262974113629CG1.00141.04140.02381.054236076888830.39217
16rs4321664096858AC0.97761.04050.02381.022733787572710.41924
16rs4229554115360AG1.00091.04010.02371.009927665307850.39217
16rs22393053977919AG0.71171.05560.03290.9982662871910.0053
16rs172563224067620AT0.91040.95950.02550.9804683154687450.18907
16rs25319773983702CG0.96690.96250.02400.9535048356652920.00193
16rs26017913983176AG0.96431.03890.02400.9480760839538930.00193
16rs24442173978388AG0.89320.96130.02490.9476909003526770.00351
16rs26017773975069AG0.78631.04300.02700.9237237445957820
16rs4371154096424CT0.92901.03740.02420.8873949984654250.31034
16rs47864503976156CT0.66390.94940.03480.8677403104689560.01018
16rs4099634072923CT0.96821.04370.02900.8541822855081720.57412
16rs25262964113728CT0.92221.07130.04720.8395314688809630.01649
16rs22834923977526CT0.66521.05140.03470.8268137315877260.0107
16rs22393043977395AG0.77331.04360.02980.8161609629435790.0069
16rs99353433985273CT0.63320.94950.03620.8158766457603290.00079
16rs20723393979717AC0.70560.95360.03380.7964232250220270.01279
16rs116492873979969AG0.78870.95990.02940.7875460389597240.01249
16rs22561564102761CT0.95850.96640.02510.7612014372860830.51254
16rs25320154068632CT0.97740.96790.02420.7535014192041990.54961
16rs25320184066532AG0.94470.96730.02470.7503125721946980.58914
16rs4054704082513AT0.95200.96820.02400.7471469690201070.33921
16rs25319994110524GT0.97971.05540.04080.7304870557820840.03448
16rs25319673992487AG0.50231.05030.03910.6788159726976860.00232
16rs47859473985500AG0.58930.95590.03700.6518899315197620.0142
16rs71959134110412CG1.00181.04660.03740.6501399178076690.05419
16rs110768034036303AT0.67470.96670.02880.6216020990518620.2599
16rs80454264093207CT0.99631.04180.03520.6120765330265630.03448
16rs71935524073077AC1.00370.97410.02320.5867002359187480.35905
16rs22384383970796AG0.54130.96460.03210.58153297905344e-05
16rs71933694073014CT0.99971.02630.02330.5793842293742350.37931
16rs47859534094852AG1.00531.03890.03490.5622494371796120.03448
16rs22384493999716CG0.54761.03580.03260.5519123333076590.06568
16rs121499234080476CT0.12591.40300.31590.5469876088785450.02285
16rs22384524008564AC0.42250.93570.06350.5292955702772120.01687
16rs110767973994296CG0.67611.03680.03450.5287082889410610.00467
16rs22834994077857CT0.96461.02570.02470.5147045612739110.18966
16rs129250703993016CT0.47011.05820.05600.506263197723160.00312
16rs124484534005413AG0.42061.06580.06390.4964816872759250.01824
16rs22384554071884AG0.95950.97590.02490.4845235586176240.18263
16rs22393104000662AG0.54921.03150.03250.4692881620183430.0552
16rs22384574079673AT0.97431.03510.03630.4668637117213610.03537
16rs72035424041006CG0.63241.03170.03310.4611750110620960.00226
16rs25320124070156CG0.98220.97810.02390.4509967379742120.49438
16rs20581664040325CT0.74190.97220.03070.4458744184869870.1354
16rs25320074084433CT0.86900.96420.03990.4421320384319780.03075
16rs21076054075790AG0.96440.96740.03640.4400933749638880.03279
16rs22393093983293CG0.61831.03720.04050.4354522882440520.00404
16rs25320114070205CT0.98030.97880.02390.4329736338409400.50867
16rs171366924008814AG0.50951.05070.05640.420216403383190.02656
16rs22393114006192CT0.42320.94590.06380.4161214015013740.01687
16rs20412454056832AT0.94750.96890.03670.4087127349415010.04215
16rs107753494019824CG0.85890.96770.03940.392116255643010.04231
16rs71968324016753AG0.52581.02830.03370.3905123101467150.018
16rs129358103989366AG0.54221.02690.03260.3820565651710270.0938
16rs26018284043872CT0.79390.97520.03080.3818472666214810.00028
16rs47864564023362CT0.92870.96900.03890.379031564355710.03448
16rs4371874092000GT0.98540.96930.03860.3773715738706750.02709
16rs22384363965386GT0.78550.97660.03060.3572387967346800.0015
16rs72061424111702AG1.00750.97560.03220.3549709352788580.07586
16rs25319614029075CT0.91960.97040.03920.3536943197152410.01436
16rs25319604029232CT0.91541.02950.03930.338565949606080.03135
16rs172562603993514AT0.49910.96420.04990.3320803146826390.02808
16rs99265864031050AG0.91451.02840.03930.3227581540533460.03448
16rs72034734080232CG0.93450.97520.03870.2868455981627020.0501
16rs10755814075899AG0.94710.97590.03880.2766264329810160.04608
16rs26017883947087CT0.70800.97950.03370.2694599635228810.00379
16rs116477783991381CG0.55550.98170.03140.2547690154718590.01294
16rs22384343954270CG0.33120.92590.13220.2512694439015060.01015
16rs121492743994691CT0.95680.97810.03810.25034096790510.02083
16rs26017964027977AG0.95790.98380.02850.2472603060646720.09982
16rs129177113989440AG0.51101.01910.03310.2468000858005840.05311
16rs107753504026862GT0.94411.01610.02810.2435160355573910.07762
16rs22384323954142AG0.33171.07770.13260.242148656314420.00962
16rs26018043987747CT0.50910.98150.03310.2416180582253250.0397
16rs110768004014909CT0.43660.95750.07790.2385232204552980.00182
16rs25319733989160CG0.45550.98160.03540.2216316566441260.06622
16rs129216973999747CT0.47180.96930.06140.2141009716156160.01908
16rs22384393971349AG0.82861.01570.03060.2140298748679900.00337
16rs72020493983242AG0.46751.03330.06580.208590084332840.01047
16rs22384433975898AG0.67810.98500.03070.2068384707544490.00154
16rs19673094005584AG0.54910.98450.03200.2039115713193310.00915
16rs125958574002593AG0.56931.01510.03100.2016947179780230.04299
16rs25319923961735AG0.83911.01640.03480.1940915449258030
16rs125986543997005CG0.89351.01780.03810.1915189434340490.02352
16rs65005774062423AT0.94401.01140.02490.1885590563258420.19474
16rs129205213987701GT0.43670.97520.06020.1692830505631020.00896
16rs25319953953468CT0.72701.01170.02800.1687062556229900.00919
16rs129205084006892CG0.54211.01340.03210.1683221508085330.01054
16rs116435963997896CT0.90071.01570.03780.1673633724032970.01054
16rs4457464089768AT0.97580.98500.03800.1611509092627450.03075
16rs116456554000336AG0.95571.01490.03810.1566426215620440.00278
16rs26017874003552AG0.43301.02610.06720.1538485234711850.01008
16rs21089874048908CT0.95140.98950.02850.1482525808667360.08637
16rs47864524011659CG0.47630.98350.04550.1457547029338810.00074
16rs108526393989841AG0.87911.01380.03820.1429692017273760.01054
16rs8796203955730CT0.72401.01010.02810.1425468829647330.0067
16rs9333923972717GT0.94730.98880.03200.1393625832262450.00403
16rs38275264015907AT0.41290.97380.08060.129537568411080.00335
16rs65005754062131CG0.93810.99190.02490.1288942990144150.20398
16rs25320134069973AT0.94681.01290.03920.1283103343144850.02778
16rs121489743975500AC0.64701.01540.04730.1265631367779630.01675
16rs20797313997134GT0.99680.98870.03620.1223407558883910.01054
16rs72049874050194CT0.94140.99230.02480.1216505777822250.21182
16rs80529064051292AT0.95081.00870.02850.1182160444066150.08226
16rs22834974006062GT0.53820.99030.03270.1163953390777080.04196
16rs3782004083182CT0.96770.98870.03830.1156011744433140.02743
16rs22393124006436AG0.47750.98720.04510.1103062085558150.00067
16rs19673084005678CT0.48151.01170.04490.0993052255476020.00011
16rs25320204064108AG0.94001.00720.02780.098487190870060.10485
16rs20412473972582CT0.98730.99190.03170.0975619438013350.00157
16rs25319683992346AG0.43781.01830.07120.09734452478207410.00716
16rs110768044044390CG0.91071.00630.02510.09474395125154870.04722
16rs25320014109390AG1.00860.99330.02730.09420411963213150.11012
16rs26018134064338CG0.94040.99320.02780.09366495819490940.11146
16rs25319883968418GT0.98330.99220.03180.09323411045927229e-05
16rs22384313948231CT0.71021.00840.03420.09258863922541380.00232
16rs22834964005993AC0.47821.01100.04510.09248115389337070.00011
16rs47864594075836AG0.96421.00900.03960.08586848736910620.01021
16rs9175224037223CT0.98271.00780.03670.0801377464444620.05419
16rs10349064068854CG0.91810.99290.03470.0767041593444960.06522
16rs72003974001617AG0.54281.00650.03210.07541061433058180.07093
16rs25319823973098AG0.46021.00760.03820.07463633264589840
16rs7302424010434CT0.55040.99380.03200.0726809750403440.0684
16rs80460073945522CT0.95160.99570.02390.0676277178520860.00841
16rs25320194064301GT0.94351.00470.02770.06298389253518580.12644
16rs19664193944794AG0.94910.99600.02390.06253226035662250.01243
16rs26018314036512CT0.98450.99420.03670.05898575629443030.05419
16rs171367334047099CG0.92971.00560.03490.05883653984152680.07136
16rs22384453990384AG0.43730.98920.07100.05630767289398330.00697
16rs20723383996928AG0.43961.01080.07090.05591232058456580.00697
16rs22307393973437CT0.52540.99490.03390.05536929814372180.00075
16rs8872454001032CG0.55411.00450.03190.05168485931065220.07543
16rs22384463990689CG0.43951.00900.07060.04604711676807690.00724
16rs99363424038075CG0.66080.99350.05300.04488976902944820.03492
16rs116479794034795AG0.98020.99570.03680.04272802000705710.05144
16rs10349054068954CT0.92541.00400.03460.04229695845116860.07586
16rs80611824010334CT0.55321.00310.03200.03470420418834380.0684
16rs171367574058392AG0.85380.99710.03470.03011835625350010.08637
16rs129334234027513AG0.89541.00320.03910.02923484021923230.02534
16rs22384263943734AG0.89421.00190.02460.02747318213414430.00464
16rs116478283991514CT0.54690.99770.03170.02548830726267160.04508
16rs25319793974068CT0.56211.00210.03530.02095267305203530.00621
16rs80641514054277CG0.92871.00200.03430.02026956933771450.08046
16rs22384243943045GT0.93191.00120.02410.01781925440359740.00653
16rs124449204047143AG0.89650.99850.03620.01412464269160630.03375
16rs171367514058180AT0.92730.99870.03430.01336260438984610.08046
16rs47864544016137AG0.45591.00150.04460.01193179660736480.02671
16rs22384273943764AG0.91120.99920.02440.01179789974121910.00808
16rs118621624053237AC0.92611.00080.03430.008153946355103320.07839
16rs22384253943055AC0.95461.00040.02380.006123085058788795e-04
16rs171367544058260CG0.92750.99960.03430.004320939488377820.08046
16rs22393134046207CG0.91591.00020.02510.002395212539545620.17641
16rs171367554058288AT0.92691.00000.034300.07692
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.