Metamoodics Gene Information

 

  Chromosome: chr22    Cytoband: q11.21    Gene: COMT

 

BP - Genomewide Association Studies for COMT


 

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Description

 
Shown here are the results for gene COMT from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
22rs1048310318300949AG0.79990.85910.06561.6848696828164(Index SNP)
22rs287104718306331AG0.80360.86110.06541.654038458186861
22rs960618618300359CG0.85611.05670.02521.539102157243450.02569
22rs574684718301003CT0.99980.95150.02351.464959186748840.01961
22rs154432518311668AG0.98961.05080.02361.444784594873930.01961
22rs88720018343666CT1.00010.92610.03721.410162056852540.08275
22rs574684618300646CG0.98811.04670.02341.291579099865290.02481
22rs17467418314025AG0.91930.95200.02691.172372295232570.07054
22rs93327118311407CT0.96680.95520.02631.088948979671870.07692
22rs88719918341955AG0.90840.93950.03601.081550257598840.06878
22rs17469918334458CT0.96540.91720.05071.055418635773070.25084
22rs17467518314051CT0.97651.04510.02611.040767750949000.07361
22rs960503018301137CT0.81491.06530.03761.033764375901420.00339
22rs933237718335692CT0.91180.94960.03360.906228218501270.00513
22rs111047718342380CT0.98380.92490.05190.8771290771355650.25084
22rs16572818337023CT0.98880.92590.05160.8664610916297820.31919
22rs17469718333832AG0.97660.92620.05170.8588639098792610.31919
22rs16581518339473CT0.89720.94820.03620.8467950999157160.07526
22rs74060318325177AG0.78741.03470.02630.713319030645070.00231
22rs251882318340188CT0.79101.05930.04570.6821455106685310.19366
22rs1215820118346749CT0.97041.05540.05430.4932244633933570.00183
22rs224071418341010CT0.86371.05400.05370.484391050765520.00212
22rs224071318341101CT0.96321.05380.05460.4726279171723880.00185
22rs599388318317638GT0.96170.97770.02380.4640732586044310.02834
22rs223939418341926AG0.93230.95320.05400.4259687322722810.00208
22rs223939518342203GT0.97720.95420.05340.4205594028602030.00183
22rs74060118330763GT0.99631.01950.02370.3820565651710276e-04
22rs223939318330428AG0.99700.98130.02370.3706923599262516e-04
22rs464631218328337CT1.00151.01750.02370.3338565727084426e-04
22rs651859118304021AG0.99721.02150.02930.3312414582490420.00513
22rs448564818299405CT0.99940.97930.02930.3229408226078390.00513
22rs75837318340394AG0.87130.96280.05360.3193019703023650.00212
22rs16577418332561AG0.76300.98060.02870.3062730510763530.01331
22rs599389118339746CT0.84571.03710.05520.2926853664112920.00208
22rs464631018308806AG0.99430.98130.02930.2834124223243080.00524
22rs1170561918304579CT0.99570.98150.02930.2803373169819530.00513
22rs17469618333176CT0.59120.97960.03680.2401056259745010.03734
22rs960503118301378CT0.95981.01470.02620.2382976324585870.01188
22rs814026518301641AG0.95890.98570.02630.2344059446805550.01188
22rs202091718308884CT0.95501.01360.02630.2158107946190390.01188
22rs599388218317533GT1.01100.98630.02730.2134615195021980.00709
22rs73786518310121AG0.95441.01300.02630.2048154103175760.01157
22rs73786618310109CT0.95630.98760.02630.1972262747080240.01188
22rs88720418347068AG0.99291.01120.02630.172049471697370.01745
22rs463318330235CT0.99080.99040.02340.1669166658216570.02834
22rs251882418342963GT0.90440.99120.02750.1262145391817990.0148
22rs464631618332132CT0.94190.99150.02830.1179310555638520.00206
22rs16584918338669AG0.92021.00740.02630.1074601953413650.01544
22rs468018331271AG0.99221.00550.02340.08894897967187350.02741
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.