Metamoodics Gene Information

 

  Chromosome: chr13    Cytoband: q33.2    Gene: DAOA

 

BP - Genomewide Association Studies for DAOA


 

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Description

 
Shown here are the results for gene DAOA from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
13rs1557072104925835CT0.73800.82400.09011.49839307758117(Index SNP)
13rs9519679104908386AG0.82270.95150.02571.270916242956390.01593
13rs4772687104911548GT0.82281.05000.02571.235599677043610.01581
13rs3916966104908896AC0.84061.04890.02601.182963773949970.0133
13rs1341403104914808AC0.84360.95370.02591.172307711325550.0133
13rs3916967104915349CT0.84400.95480.02591.130533589919130.01365
13rs2391191104917447AG0.84470.95540.02591.107961079658710.0133
13rs7986339104928953AG0.89001.04760.02711.066107964235790.09568
13rs9558574104943926AG0.97190.95990.02421.040672354027830.01484
13rs7998530104930720AC0.92050.95960.02540.984221243610960.01299
13rs1341406104948881CT0.99730.96020.02490.984221243610960.08397
13rs9558579104946679CG0.99071.03960.02400.9759250126925740.01484
13rs1539070104922458CG0.95360.95340.02960.969400278034050.1453
13rs954580104949855CT1.00231.04090.02490.968187728669630.08046
13rs9558567104929595AT0.91881.04170.02540.967381239149280.01299
13rs12583219104932990AT0.92180.96040.02530.956244873031320.01267
13rs9558568104930220AC0.92001.04100.02540.9476909003526770.01299
13rs9558576104946286CG0.93500.96140.02490.9457700901366030.01331
13rs778327104950903CT0.97301.04090.02540.942333896090170.02692
13rs3916968104925530CT0.89280.95830.02700.938170692705300.0927
13rs9634548104945934CT0.93731.03960.02490.9251835593548250.01277
13rs9558581104946804CG0.93401.03960.02490.9251835593548250.01277
13rs11069596104944360AG0.89180.96090.02560.9240882385172230.0122
13rs9558571104936367CT0.92171.04020.02540.9211808169011510.01251
13rs9558578104946582AG0.99051.03800.02400.9208187539523750.01484
13rs9634547104945866CT0.93370.96210.02490.9161391991334270.01353
13rs2111802104950621CT0.98180.96340.02410.9161391991334270.01505
13rs7332963104933608CT0.96270.96420.02430.8722474841670270.01451
13rs9634546104945815CG0.93231.03790.02490.8690233083943830.01277
13rs7139958104934733AT0.96230.96450.02430.8620132672764680.01484
13rs7984976104935462AC0.96331.03660.02430.8560488835760360.01451
13rs9558570104936261CG0.96300.96490.02430.8501653032842150.01318
13rs3918341104918420AG0.86671.03740.02500.8480176045425260.01744
13rs1341401104913158CG0.29321.12990.09620.6899442622491090.00111
13rs4598771104938781AG0.94601.04310.03450.6554112574212860.20949
13rs17713906104912457CT0.30340.90550.09300.5442417968958630.00111
13rs2893229104929201AG0.90241.02500.02520.4850539946919960.04429
13rs12876563104931760CT0.99530.97310.03050.4295738216410270.00374
13rs954581104950267CT0.99441.02700.03060.4161214015013740.00345
13rs12865487104950681AG0.99341.02700.03060.4153296155356510.00345
13rs16966707104948205AG0.99521.02600.03050.3970722871408110.00345
13rs9670704104927721AT0.90590.97920.02520.3952341152961130.02948
13rs9519686104927899AT0.90641.02100.02520.3880643749598770.02878
13rs8002278104935155CT0.96731.01890.02380.3648179513437320.02437
13rs947267104937663GT0.96691.01800.02380.3440935818197850.02437
13rs9555175104943461AG0.75941.01980.02670.3345128192171890.02724
13rs701567104939996CT0.96881.01760.02380.3341376997968450.02478
13rs2153674104929139CT0.98191.01560.02340.293623644160310.0294
13rs10492528104924887AG1.00130.98150.03020.2705922030369320.00366
13rs7988538104945044AT0.66241.03110.05800.2237347817318910.05276
13rs7985577104919903AG0.71391.02900.06100.194567111867869e-04
13rs9586864104931366AC0.72420.97220.06020.1941594511853270.00112
13rs9301030104924309CT0.91600.99010.02540.1582027011256450.02028
13rs7329925104938737CT0.28210.94400.15020.1539723246356210.00044
13rs9583000104931276CT0.72350.97810.06020.1466668949976650.00112
13rs9583001104931340CT0.72300.97840.06020.1446020033459310.00112
13rs9586862104929883AG0.72270.97870.06020.1417636645704870.00118
13rs4771497104930845AG0.72281.02150.06020.1405614645449440.00114
13rs9586861104929873CT0.72270.97920.06020.1382864124285660.00112
13rs9284229104931159GT0.72480.97960.06010.1359638172742250.00112
13rs9586865104931434CT0.72261.02060.06030.1335354340282600.00112
13rs9583002104931633CT0.72311.02050.06030.1328272488213500.00112
13rs12584039104920864CT0.71430.98080.06090.1248229401852960.00111
13rs7987770104945199AG0.72721.01890.06000.1218805153028320.00111
13rs9519681104924828GT0.12451.04520.17090.0990869322623310.00137
13rs7995553104942346CT0.87691.00600.02650.08597434830367130.01727
13rs12583208104911914CT0.66581.01320.06260.07878187880504970.00111
13rs1341402104913510CT0.83031.00610.02900.07836553894629460.01432
13rs12585199104913388AG0.66641.01250.06250.0743785452091710.00112
13rs7321928104908141CT0.66401.01200.06260.07099001450603880.00112
13rs9284226104928138AG0.14821.02270.12500.06676587128519190.00179
13rs778326104948042AT0.98780.99570.02560.06163040254819370.01709
13rs6491961104928380CG0.92390.99580.02530.06143024377893880.01984
13rs7321955104908237AG0.66521.00830.06250.04812844287163560.00112
13rs7322456104908285AG0.66440.99180.06250.04807992647970640.00111
13rs11069595104929618AC0.98860.99670.02550.0466269492733040.01734
13rs12584489104913592AT0.66840.99360.06230.03729926829565890.00111
13rs778324104945573AG0.98761.00260.02560.03682628362474840.0176
13rs7989006104932855AC0.98811.00240.02560.03442204208947210.01701
13rs9514392104943370AG0.91560.99750.02620.03418704696339690.01563
13rs2226083104930984CT0.98821.00230.02560.03198428600635820.01107
13rs778294104940236CT0.98691.00170.02560.02342078135989000.01709
13rs12864685104941856CT0.69421.00220.03620.02195650609003710.0077
13rs12874006104918986GT0.96951.00200.03690.01890657685407020.00285
13rs9519689104943481CT0.93551.00020.02610.003225729138695430.0169
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.