Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: p15.3    Gene: DIP2C

 

BP - Genomewide Association Studies for DIP2C


 

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Description

 
Shown here are the results for gene DIP2C from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
10rs17158845318070AG0.80120.84120.06522.09783387072895(Index SNP)
10rs10904498591355AG0.98401.12790.05061.762959208620810.11201
10rs2018975307501CT0.96361.05840.02561.578889870206570.0269
10rs10736957305525AT0.85491.14040.05981.552221990705380.99999
10rs12763075556152CT0.22500.62830.21961.464199709175100.00029
10rs11253096580418AG0.99381.10790.04921.427128397799520.24052
10rs12049717591031AC0.95770.89380.05501.386263858738130.24044
10rs17159658588279CT0.96400.89620.05431.362010219215310.24052
10rs11252886550073AT0.84511.11170.05581.239652921470090.14636
10rs11253087578609AG0.96570.90400.05521.172049471697370.00014
10rs3123232338775CG0.95140.95100.02831.120674699215190.00087
10rs11814503583435CT0.95600.90760.05491.111259039317110.00014
10rs11253144586714AG0.96190.90890.05471.091890459607450.24052
10rs4881041343306AG0.96171.04240.02501.015292705517330.01144
10rs11252468481349AG0.88540.92880.04471.008330992620050.06297
10rs11814991378556CG0.68240.91040.05810.9726503922252440.00091
10rs4506561370594GT0.53091.14430.08460.955460239607590.00059
10rs7902669389104AG0.66291.15640.09240.936666641048250.00045
10rs4880568303504CT0.97650.96300.02460.9013562741829430.02597
10rs4881335509830AG0.79700.90570.06750.8464900106991620.00061
10rs10751982511482CT0.93310.90340.06980.8362424760180440.00048
10rs2066316510164CT0.96431.10190.06760.8218867476853680.00044
10rs10795193510540AG0.94850.90630.06890.8153085691824010.00044
10rs10904306510368AG0.95710.90730.06840.8096683018297090.00045
10rs2153752510192CT0.95441.09760.06760.773657912836370.00015
10rs11252820538089GT0.94391.06310.04450.7708302974608990.04601
10rs7903826507942GT0.95690.91160.06740.7703181576823240.00044
10rs2050968543253AC0.93690.94660.04210.7173778871219370.04601
10rs2794954595525AG0.80140.95490.03610.6974526275125140.16248
10rs1672534616897CG0.25770.77200.20370.690582774221860.49367
10rs7070654367161CT0.88741.03180.02590.6447400944726220.01064
10rs11252842542355CT1.00470.95180.04200.6188849192901490.06297
10rs816600537254AG0.51151.16060.12810.6111885865264760.49367
10rs3125027316894CT0.98130.97350.02460.5606673061697370.02691
10rs2288681363048CT0.85411.06400.05800.5456125328530459e-04
10rs12358336556981AT0.99431.02620.02440.5397036732425250.00959
10rs10903803303000AG0.92021.02720.02540.5367043900379970.00837
10rs11252926556379CT0.99571.02600.02440.5352124803540630.00959
10rs816651591114CT0.92531.03810.03600.5238932831598090.23387
10rs11252923556195AG0.99460.97510.02440.5210008683266430.00959
10rs7916145389914CT0.74240.91810.08360.5130031115681770.00044
10rs2288680322199AG0.17171.18950.16990.5127201835569310.15616
10rs10903832310954AG0.96640.96700.03380.4940364819818740.00033
10rs4881399557325AG1.00320.97630.02420.4918744639168010.01008
10rs1539230512487AG0.71551.10860.10680.4756038778961580.00014
10rs10904138441700AG0.93801.02370.02440.4737899961583360.01166
10rs11251372305644GT0.98370.97690.02430.4732731326853640.00891
10rs10903844317832AC1.00120.97810.02330.4678828837511960.01724
10rs4520520387143CT0.18300.83270.19240.4667364832212850.00029
10rs2066315504138CT0.99300.94220.06300.4628107737563550.00044
10rs11252791534349AC0.53350.89540.11690.462684726887990.49367
10rs816602535195CG0.47570.91640.09240.4625587165920520.15616
10rs7100363583382AG0.94331.03860.04120.4451475656279460.17439
10rs10903945353275CG0.92680.97830.02420.4379451703436210.01783
10rs4881224431442CG0.92950.97810.02450.4365189146055890.00129
10rs10903806304421AG0.98311.02220.02430.4352156154960130.00885
10rs12415961458599CT0.96060.97850.02460.4251588049366150.00927
10rs7896421309879CT0.98380.97920.02430.4128505017456560.00891
10rs12359454558081CT0.94910.98000.02390.3989182722159770.01783
10rs10795124457785AC0.95890.97950.02460.3975059311927190.00927
10rs3123247300225CT0.84321.05290.06170.3942641061232531
10rs816583545223CT0.95980.97060.03610.3902988976206000.20755
10rs12261462602945GT0.26200.84970.19770.3871102307125150.49367
10rs11252614508199AG0.48901.05940.07010.3868984830330870.00114
10rs7912391567444AG0.98900.96610.04240.3812199754937850.06297
10rs6560848545246CT0.94501.02920.03550.3808022842070530.17898
10rs7071018545514CT0.95980.97160.03590.3738650213646110.21217
10rs10795167494878AG0.95811.05340.06500.3730440485645530.00044
10rs11252809535945AG0.61451.07500.09080.3711004355793930.24052
10rs17221323608685CT1.00771.02320.02910.3660268442103260.00384
10rs1621280556592CT0.82911.02840.03550.3660268442103260.14615
10rs816623599945CT0.64661.05370.06870.3504704340521810.15616
10rs3922851397584AG0.89630.98120.02510.3476569449372850.0127
10rs7914425585877AG0.99840.96900.04220.3419886033428880.06364
10rs11253065573548AG0.98760.96860.04310.338565949606080.06364
10rs7074740586770CT0.98961.03190.04240.3381873144627390.07322
10rs11253136585674AG0.84690.96020.05500.3373365904259620.00076
10rs11252919555831AC0.98810.96910.04260.3353580244438740.0623
10rs11253246606610CT0.84931.04080.05530.328364403397870.00106
10rs17221260315841GT1.00270.98300.02390.3256901110585230.01122
10rs17159685607663AG0.21671.15300.19820.325506282703650.49367
10rs11252313454904AG0.50591.05190.07060.3244966152720430.00076
10rs4242757407250CT0.51611.10440.14010.3199365725180510.00014
10rs7076375582926GT0.98230.97660.03350.3194831906187450.18506
10rs17293454623495CT0.72421.02980.04170.3172233536855660.00173
10rs7085214458133CT0.88830.98280.02470.3163227011813080.02296
10rs11593378582873CG0.72271.02080.02950.3136318965269640.00762
10rs11253253611653AG0.78231.05660.08010.3082114755973020.49367
10rs816622597307AT0.90920.97460.03780.3045183235098030.23567
10rs2386705550600CT0.96021.02320.03420.2998156703778020.18506
10rs7912017564892CG0.95440.97690.03490.2986911147719250.16667
10rs10466270546129AG1.00420.98460.02330.2961070463674550.01989
10rs12357593315134CT0.99890.98430.02390.2935382623686450.01099
10rs3123242309493CG0.25611.15230.21460.2934528973596430.00014
10rs7096559489188AG0.97370.98450.02360.2933675491267050.02071
10rs11252337457958AG0.83320.96450.05490.2923446764688130.00062
10rs7906612563131CT0.98741.02840.04270.2906452241656040.06297
10rs7896737455649CT0.95861.01610.02460.2872661409300480.00893
10rs6560836434997CT0.96761.01540.02370.2857540889821060.02351
10rs816643577401AC0.98600.97270.04300.2834958362267830.0603
10rs12252088579196CT0.99561.02790.04280.2831622767004760.06364
10rs17159728634015AC0.88311.03140.04920.2758060804856700.00107
10rs4881331507451CG0.97240.96060.06420.2749054789185310.00044
10rs1750792728630CT0.99320.97360.04290.2728655762395110.00074
10rs12570174629750AC0.89710.94700.08750.2727841790915070.49367
10rs7068385560543CG0.97390.97860.03500.2706731903531390.20755
10rs11253259615356AG0.71171.05070.08050.2681695797118380.23933
10rs11252917555362CT0.96480.97910.03500.2620920766253610.20591
10rs865289585504AG0.84950.98480.02550.2616158764878440.0269
10rs816608654615AG0.90051.02810.04610.2615365605380480.00106
10rs17159703616412AG0.95091.03030.05030.2576677176428520.00089
10rs816593539642CG0.88060.93840.10720.2569608451950670.00014
10rs4488125427940CT0.97390.98610.02380.2550814575586470.01251
10rs947469522162CT0.49741.06940.11470.2528990686350140.49367
10rs17159707621666CG0.94790.97120.05020.2509597312965430.00089
10rs3131998324063CT0.96151.01560.02680.2495687513397980.00383
10rs10904083419977AG0.98360.98600.02460.2469534383734710.00795
10rs10795103441849AC0.94720.98660.02400.2407855687657560.02337
10rs12263864465035CT0.57271.07350.12670.2398792147354320.00044
10rs2050969543407GT0.94900.98680.02400.2382976324585870.02104
10rs2085345653443AC0.89921.02630.04660.2382224624918220.00062
10rs17159676604358AC0.46050.94820.09570.2376215706880360.24052
10rs816640569869AG0.96720.98150.03400.234554981909850.16667
10rs12265644604946AG0.44751.05420.09610.2343314452409860.24052
10rs4881313477973CT1.00210.98740.02320.2330669061627160.02303
10rs4472852653682CT0.84071.02550.04670.2288536511850150.00113
10rs12776623405242CT0.58210.95360.08880.2271650727609820.00059
10rs10751997551952CT0.99800.98770.02330.2261404476233130.01608
10rs3125028321398AG0.93491.01800.03360.2249723999011550.00311
10rs7080530585469CT0.96261.01830.03510.2181728470675720.20257
10rs11252492485452CT0.96901.03150.06200.2099260515736950.00044
10rs11253244606500CT0.91141.02440.04830.2095740826088890.49153
10rs7092412419932CT0.95411.01240.02480.2092223986623060.00826
10rs10904450578406AG0.97240.98270.03520.2083795173071860.19923
10rs4880704556395CT0.95870.98300.03450.2083093509798820.18506
10rs4554800448477GT0.97120.98860.02360.2030096094543140.02223
10rs11253163588813CG0.93730.97860.04480.2012803148149940.0756
10rs919643347849CT0.92630.98010.04190.1997642106726460.00156
10rs816620635916CT0.95521.01140.02390.1974999322356070.00055
10rs9804310354399AG0.96550.98440.03330.1959287511143390.00274
10rs3935081459349AG0.96960.98840.02500.1926679607088100.00754
10rs11594718422103CG0.93851.02760.05970.1879561020697730.00029
10rs17159679604898CG0.18831.10780.23220.1808510571928660.49367
10rs816621636219CT0.85100.97880.04850.1807193530275190.00111
10rs1672503560172CT0.94900.98960.02440.1746388040473670.01027
10rs816627608409CT0.93200.98400.03780.1745738822321770.26985
10rs2386709652193AC0.94711.02120.04940.1736012178123820.00074
10rs7908298317780CT0.97951.01610.03770.1726307269461750.0019
10rs17221309605782AG0.85750.98930.02570.1709536631468170.01253
10rs12246970414200AG0.96371.01400.03330.1700533040583640.00221
10rs12245012413555AG0.98991.01400.03330.1694754859027420.00917
10rs11253082578126CT0.99311.01710.04100.1677466298029920.06297
10rs574112729162AG0.89251.01980.04740.1676188397529599e-04
10rs3125026316214AG0.36320.93060.17900.1625378285140050.00014
10rs17136375698293AG0.98691.01970.04950.1590161626796220.00075
10rs12252141579228CT0.91791.01700.04320.1570788792400180.05308
10rs3740304313283AG0.98890.98980.02670.1549019599857430.00406
10rs7074221403440CT0.78411.01030.02660.1539723246356210.0234
10rs17159756652688AG0.86900.98190.04810.1526124489726058e-04
10rs943203723392AG0.76340.98150.04900.1525507375008270.00106
10rs10904199461516AG0.86770.99020.02580.1521190025546250.00889
10rs9787422403010CT0.85330.98830.03140.1499054056132990.00017
10rs816570670475CT0.88660.99070.02570.1445414196139640.00108
10rs7095189616782AG0.99431.01400.04030.1366176515592120.06364
10rs4242758416966AG0.96560.99150.02460.136498699358550.00763
10rs10128312614127CT0.79661.02860.08400.1323557660969020.49367
10rs705488732145CG0.89081.01590.04760.1304162922865769e-04
10rs2124585670428AG0.86590.99150.02580.1298888446355990.00087
10rs12763675734591CT0.87560.99150.02590.1289527386945010.00145
10rs7913021589732CT0.97371.01460.04490.1267956907229590.09558
10rs816650591089CT0.98151.01420.04460.1239554497539050.09654
10rs4880678480472AG0.99350.99290.02330.119415043935020.02104
10rs4881278456286AG0.91960.99220.02570.1189578918065940.00744
10rs7077209474159CT0.95971.00720.02370.1178740802299680.02256
10rs816628609170CG0.97840.98940.03520.1173047376184030.23567
10rs7088729406444CT0.81840.98880.03820.1149216158507760.00346
10rs12765028391093CT0.52030.97570.08410.1134528766088940.00074
10rs7093951591771AG0.96780.98710.04490.1123826996642640.09654
10rs12251997544186CT0.88911.01840.06330.1117081546434850.49367
10rs11253260615483AT0.89171.01210.04220.1109225073499360.05134
10rs4880567303304CT0.92281.00720.02510.1105302160304930.00231
10rs7903876472678CT0.98621.00660.02340.1081281695544160.02071
10rs4881219425880CG0.98070.99360.02340.1062382379420570.01925
10rs11252754528637AG0.97981.00650.02360.1052410056281080.01834
10rs4573619413211AC0.93920.99360.02410.1025928603384203e-05
10rs10904172452298AG0.79331.00740.02810.1007815821486270.00749
10rs10128281613841CT0.80211.02160.08360.0980515349269160.24052
10rs7082405608841AG0.98240.98700.05160.09739886933346870.00074
10rs11252332457318AT0.94630.99380.02470.0956632077975050.00925
10rs17293419527014AG0.97340.99430.02360.09301884677114590.01727
10rs3750730689089AG0.86190.97940.08570.09274991711867160.00014
10rs10904173452885AG0.91601.00590.02460.09103269958161220.01076
10rs3922852397657CG0.91201.00550.02440.08507535179485150.01558
10rs1539231520644AG0.95741.01370.06240.08244197917456390.49367
10rs12242090599078CG0.72000.97790.10370.08107890990866420.49367
10rs4881333509164CG0.92700.99490.02410.07925073872429170.02104
10rs12261918318690AC0.98750.99230.03800.07660053384128350.00113
10rs7918643337752CT0.97030.99340.03290.07556563645676940.00252
10rs11251963408676AG0.86471.00500.02490.07453319930846211e-05
10rs885593530161CG0.93560.98620.07060.07355465218161070.49367
10rs7895529347599AG0.96270.99240.03930.07283502570063010.00173
10rs1773487617233CT0.62421.02200.11340.07186029312488020.49367
10rs11252756528811AT0.93151.01100.05860.06971335275448040.24052
10rs1769236724229GT0.93681.00800.04520.0650977416776869e-04
10rs12258965521982AG0.66190.98310.09750.06474471821595270.49367
10rs816646582283AG0.84540.99560.02550.06464390705442690.0148
10rs725314308677AG0.98001.00460.02650.06378795567975120.00546
10rs10904535686237AG0.90940.99210.04640.0631847688023670.00092
10rs3125034338019CG0.96640.99450.03300.06133019897732080.00266
10rs12249596583646CG0.47780.97540.15460.05943371350990980.49367
10rs4881308474983GT0.97271.00370.02350.05714899344566260.02071
10rs1672535617211AC0.90561.00620.04030.05625823416868620.23718
10rs12246027308076AG0.97961.00390.02650.05403929642243140.00552
10rs2050970505870CT0.99511.00330.02330.05168485931065220.01958
10rs2096134523331AG0.90091.00800.05940.04919717703534151
10rs11253256613410AG0.95600.99680.02380.04885683989244740.01783
10rs12573723405651AG0.40680.97850.16390.04832256265669940.00014
10rs12261505321054CT0.93790.99550.03540.04633693625290870.00263
10rs3815985319493AC0.98090.99580.03840.04014804520039470.00176
10rs2066317510309CT0.98611.00250.02340.03867384406528910.01958
10rs11252693522139CT0.97811.00250.02360.03843653763793050.01834
10rs11252630511186CT0.98530.99770.02350.03536329621149850.0192
10rs1133113402449AG0.88911.00250.02600.03489241415094410.00898
10rs4880660453246AG0.69641.00290.03160.03259244340252720.00409
10rs816613624679AG0.86111.00370.04260.03105031901865740.21536
10rs10128217616237AG0.32640.98570.17940.02867775475718710.49367
10rs816599537567AG0.82381.00530.06820.02784346414050640.23944
10rs12761735631961CT0.89971.00300.03920.02770457138886040.00288
10rs11251599343532AG0.62150.99550.05870.02714944415276990.00082
10rs3097730349403AC0.97640.99790.03270.02236783475400050.00283
10rs11251600343589CT0.93350.99790.03810.0198147630526650.00212
10rs17159691609316AG0.80561.00460.08290.01976930860896830.49367
10rs2605905596908CG0.95001.00230.04290.01904268377037980.07718
10rs3131999324799CT0.89900.99820.03490.01845319495476380.00263
10rs17159711626509AC0.88090.99610.07990.01709588220737190.49367
10rs12245224611338CT0.89610.99670.07490.01542768437836780.24052
10rs2380151339241CT0.99030.99880.03780.01086177578421090.00194
10rs4881337519144AG0.49701.00350.12240.01010543628122690.24052
10rs816598537658GT0.90631.00090.06220.00502332635030890.24052
10rs3125031328553CT1.00090.99970.03140.003050751504618820.00302
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.