Metamoodics Gene Information

 

  Chromosome: chr11    Cytoband: q23.1-q23.2    Gene: DRD2

 

BP - Genomewide Association Studies for DRD2


 

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Description

 
Shown here are the results for gene DRD2 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
11rs4586205112812339GT0.96901.08270.02732.43616308133545(Index SNP)
11rs2002453112794508CT1.00530.92870.02702.206838470754450.9449
11rs4648318112818599CT0.94951.07940.02792.203981030652850.9449
11rs2005313112795259AG1.00391.07360.02712.057694247104110.9449
11rs1076562112801218AG0.99261.07400.02732.051978466858900.9449
11rs2245805112795909GT1.00570.93180.02702.045660991397540.9449
11rs2440390112792088CT0.99840.92680.03481.537452271197340.44954
11rs4483623112857767CT0.84341.17860.07631.504594436853810.0755
11rs12574471112821446CT0.78180.91690.04151.436875039661960.42609
11rs17601612112822955CG0.97030.95260.02441.338092707233980.08545
11rs4938017112809139CT0.98170.95530.02401.245422343955270.42308
11rs7122246112809667AG0.97950.95570.02401.226067352532350.42627
11rs12800853112807724CT0.98461.04550.02401.198733529510380.43954
11rs12364283112852165AG0.91040.92120.04431.195111255377610.00082
11rs12364051112810524AG0.95361.04590.02431.191114132640190.42943
11rs12805897112829503AG0.87361.09110.04791.161276809968630.00405
11rs1116313112801317AG0.98431.04440.02401.158015195409890.43954
11rs2734831112798806GT0.98210.95890.02401.097181531917750.42943
11rs12363125112791126CT0.98991.04250.02391.090550953018730.43255
11rs7131440112805120CT0.98151.04140.02401.042584285277330.42129
11rs6589377112860946AG1.00231.04150.02411.039767126871490.08076
11rs2734837112792039CT1.00311.04060.02381.027750864037400.40638
11rs2734833112798130AG0.99700.96110.02391.015022873584510.40616
11rs4436578112811975CT0.94901.06150.03611.006563769502390.44954
11rs1076563112801119AC0.98881.04010.02391.000173752545590.43255
11rs2734842112785484CG0.98480.95920.02550.9897000433601880.53012
11rs2587548112797422CG0.97940.96200.02400.974284616098660.43255
11rs2734839112791700CT0.99601.03900.02390.9641701747471720.38266
11rs2734838112791711AG0.98801.03900.02390.9605858808238630.43255
11rs4630328112839419AG0.99040.96170.02440.9578184054842340.07253
11rs6275112788687AG0.98991.04130.02550.9484616094846730.45223
11rs2859545112776550CT0.98181.04130.02560.9465373950745450.39777
11rs1003641112778846AG0.99091.04070.02550.9288547095489170.45689
11rs2242592112784640AG0.99410.96110.02540.9259153109717560.45689
11rs4587762112812103AG0.92730.96170.02540.9041335465214570.3139
11rs2587550112778135AG0.98510.96180.02550.8972233851165590.50359
11rs6276112786607CT0.97681.03940.02560.8847224086040990.49749
11rs2734841112786986AC0.99061.03880.02550.8677403104689560.45689
11rs6279112786283CG0.99260.96300.02550.855737226238010.45689
11rs17115583112814112AG0.99731.05390.03630.8279811905754440.37984
11rs4620755112814829AG0.99551.05310.03640.807711387431880.40496
11rs4245146112823183CT0.99871.03200.02330.754487332185850.00995
11rs17529477112822277AG0.99860.96690.02510.7471469690201070.07499
11rs4245147112823217CT1.00200.96960.02320.7354182707619230.00995
11rs4274224112824662AG0.99981.03080.02320.7180580665591750.01348
11rs10891556112857971GT0.98580.96410.03050.6378946807062270.03728
11rs4938019112846601CT0.98781.03830.03330.5875394525700390.00504
11rs1124492112787485AC0.99351.04190.03660.5820303577852630.40496
11rs4350392112840927AC0.98421.03600.03340.539553216119280.00504
11rs10891552112838881AT0.89741.08980.08540.5036239459875990.00189
11rs10891549112783657CT0.99060.97720.02350.4854522473397140.26229
11rs1554929112783974CT0.99061.02320.02350.4825401734597680.25967
11rs7122454112832678CG0.99301.03260.03330.4735314875305230.01135
11rs7131056112834984AC0.99961.02210.02350.4530873568187580.03002
11rs2234689112783693CG0.99480.97260.03000.4519793050944690.12015
11rs1079727112794392CT1.00680.97190.03180.4315635855831150.04223
11rs2075654112794276CT1.00541.02800.03190.4138629747692070.04223
11rs4648317112836742AG0.99141.02930.03340.4121768286810450.01135
11rs11214611112835429AG0.97270.97160.03340.4112802203999430.00716
11rs2283265112790746AC1.00440.97320.03190.403402904373540.04328
11rs1079594112788022AC0.99831.02740.03200.3997896935906720.04059
11rs1079595112787879AC0.99781.02730.03200.3994627056355310.04223
11rs1076560112788898AC0.92540.97170.03410.3982658517398950.03162
11rs2734836112796449CT1.00411.02710.03190.395773946915530.0401
11rs1124491112787300AG0.99790.97370.03200.3940488424351270.04223
11rs2471854112804849CG0.99820.97450.03180.3800722897085320.02375
11rs10891551112837505AG0.99441.02730.03340.3778896396387810.01135
11rs6277112788669AG0.97700.98110.02370.3758210742519780.2562
11rs2734848112775584CT0.98011.02440.03010.3744817710283620.18071
11rs1125394112802395CT0.95900.97610.03210.3459197646934290.0242
11rs2471857112803549CT1.00641.02380.03180.3368646850422460.02375
11rs7103679112808884CT0.99901.02370.03210.3318005158013380.04223
11rs7125415112815891CT0.89800.96960.04230.3315208970674140.31818
11rs4936270112823618CT0.97640.97250.03830.3311483519174810.30425
11rs1079596112801829CT0.96361.02350.03210.3291977157390560.02375
11rs4245148112825629CT0.97240.97280.03830.3269790928711040.26119
11rs7350522112810413GT0.99811.02340.03210.3264262035769480.04223
11rs11214607112817349GT0.99400.97750.03210.3206629694792060.0406
11rs1079597112801496CT0.96231.02200.03210.3025962767995120.01938
11rs11214601112777972CT0.98461.01920.03210.2577463300934060.0358
11rs12422191112779220AG0.87190.97750.03930.2501864147070620.00561
11rs2511520112779981CT0.17721.09200.15690.2403321553103690.00698
11rs11214606112815079CT1.00870.97150.05160.2396529214700940.01391
11rs11214599112776570CT0.98481.01770.03210.2333641136897320.03624
11rs4648319112819573AG0.98950.98300.03200.2268720759666650.04223
11rs2471851112806279AC0.96201.01710.03200.2241711855353880.02302
11rs4460839112827006CT0.96361.01450.03900.1478861391502380.19386
11rs4936274112835661AG0.98481.00830.03920.07956359344924140.24755
11rs1800497112776038AG0.94430.99440.02970.07093887591523460.03879
11rs1799978112851561CT0.97161.00890.05320.06163040254819370.01341
11rs1800499112792904CT0.36831.00900.09850.03277974021703260.00774
11rs11214613112840469AG0.98171.00140.03920.01260190086298260.23882
11rs4581480112829684CT0.99151.00090.03910.007667440952535690.24868
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.