Metamoodics Gene Information

 

  Chromosome: chr3    Cytoband: q27.1    Gene: DVL3

 

BP - Genomewide Association Studies for DVL3


 

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Description

 
Shown here are the results for gene DVL3 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
3rs2175525185369639AC0.74240.91000.04811.30163843394489(Index SNP)
3rs2231224185383975AG0.95270.95970.02990.7703181576823240.01206
3rs8478185382526CT0.95201.04140.03000.7554754884299160.01525
3rs4912474185349180AC1.01521.02650.02450.5440897596172570.19691
3rs1976700185375965CG0.85320.97150.02730.5385014732169810.24812
3rs4575925185349537CT1.01771.02570.02450.523603173274670.19691
3rs4912527185352567CT1.01320.97540.02450.5086383061657270.19691
3rs843366185383374CG1.00661.02460.02490.4826721177056260.17258
3rs843369185379862AG1.00241.02370.02500.4580465255417640.21232
3rs16858473185350316CT0.83461.07410.09570.3423705686110480.00068
3rs844540185346507AT1.01650.98310.02460.3113132757158770.20509
3rs2231216185379335CT0.70641.01460.02760.222428195308590.05765
3rs1709642185364469AG0.94280.99000.02390.1714689933548990.1097
3rs843346185376213CT0.80491.01280.03190.1610879725940010.01525
3rs843360185348494AT0.95701.00810.02380.1337717526203530.0991
3rs843368185380319CT0.97271.00530.02350.08444188458847960.06576
3rs843367185383032CT0.97590.99670.02340.05183163827286830.06828
3rs843365185383423CT0.97830.99700.02340.04599883231842980.06401
3rs843364185383530AG0.97990.99710.02340.04469717723830830.07505
3rs11919795185373562AG0.86030.99770.02780.03016490692420260.26641
3rs1969253185359206AC0.93130.99890.02400.01691522726221150.06179
3rs2231223185383886AG0.42711.00220.09270.00824246046565190.00579
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.