Metamoodics Gene Information

 

  Chromosome: chr9    Cytoband: p21.3    Gene: ELAVL2

 

BP - Genomewide Association Studies for ELAVL2


 

View in Genome Browser

 

Description

 
Shown here are the results for gene ELAVL2 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
Download:
   
Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
9rs1096603923705981CT0.94841.07140.02811.85294232897164(Index SNP)
9rs136022623703284AG0.94760.93540.02771.804653941651580.9589
9rs1690772323773166GT0.96820.84870.07491.543330370576240.00778
9rs78346023787136CT0.34181.25310.13451.029513651152350.01153
9rs818113323791406AC0.90171.12400.07001.022916879684150.01138
9rs132902823677097CG0.90330.95300.02911.008596697419960.10126
9rs132902423696348CT0.99871.07200.04240.9952488444090.30233
9rs1073867923675236AC0.89441.04750.02860.9804683154687450.10884
9rs1073339323737362CT0.50040.85490.09890.9473060580750320.01168
9rs969713123685277CT1.00120.93830.04230.8787685448503790.30233
9rs1096603223695108CT0.97540.95470.03300.7964232250220270.43469
9rs1096607523759881CG0.99711.06550.04540.7902169851514850.03053
9rs1223527423757062CG0.99861.06440.04530.773657912836370.02793
9rs1096603723704475AT0.94450.95580.03300.76674999045890.49917
9rs1692365123739865CG0.91671.06260.04460.7604502791595270.03182
9rs1096602723684556CG0.97331.04570.03300.7559704109699780.47195
9rs72775823692730AG0.98941.04120.03000.7466619946738940.40527
9rs818112823791297AG0.97720.94370.04370.7332980331159120.03139
9rs1096603823705614AC0.94331.04440.03300.7246886454581880.49917
9rs1096604123708281AG0.93990.95770.03310.716698771296450.50549
9rs136009123705657CG0.90640.89730.08400.7059749059046770.01552
9rs136022523703148CT0.94551.04340.03300.7039933306863280.49917
9rs1690778223792442CT0.98601.05720.04340.69853592685670.0318
9rs929885023755511CT0.75760.96650.02690.6873995607387410.01677
9rs382908823703680CT0.94811.04260.03300.6865546295735860.49917
9rs141084023692349GT0.99860.96400.02990.658169943079490.40527
9rs1049181723759754AC1.00290.94670.04500.6511112769285620.02793
9rs1081196823775380CT0.98391.05390.04430.6272720591144050.03138
9rs1234179323819824AG0.99371.03790.03200.6111885865264760.0242
9rs1096603123693900AG0.88380.95890.03610.6101254416090150.3629
9rs1081195523687417AG0.95361.03530.03020.602233743873550.37184
9rs786980623821031AG0.95641.04520.03860.5970511706555950.00958
9rs1690781323817873CT0.99321.11000.09130.5970511706555950.00758
9rs132902523688373AG0.93561.09990.08370.593289541390210.01562
9rs172825623780801AG0.98421.05080.04420.580705278246540.03139
9rs1690773823779876GT0.98561.05070.04420.5790545940780280.03138
9rs1096604823718707AC0.87491.05700.04970.5772460586986520.04791
9rs132903823818146AG0.97830.90250.09210.5760990814715830.00758
9rs1690774623779938CG0.98561.05010.04410.5725138909042140.03139
9rs78345523822770AG0.85950.97020.02740.5694412304772420.07564
9rs963288623779405CT0.98590.95250.04420.5667103148049740.03179
9rs132904423737791CT0.98500.96670.03080.5644741485013450.0548
9rs1096608323799492CT0.68081.06430.05690.5628839069519210.06355
9rs703852523762277CT0.98941.03420.03080.5612994670992640.0548
9rs448629123711025CG0.78220.95190.04570.5522219907053790.02869
9rs238326823671361AC0.79441.02850.02600.552067134407820.00483
9rs379357623727408AC0.90221.05320.04830.5477534254795630.04791
9rs1690760023671975CT0.78871.04890.04510.5385014732169810.20235
9rs1690769523743106AC0.94030.95550.04340.530914700876880.03182
9rs99254923778043CT0.97710.97120.02820.5231683714877390.04764
9rs221750423672669AG0.75691.02930.02850.5090587946432130.30789
9rs95909123765449AG0.94840.95610.04430.5068208793174850.03139
9rs141084723700663AT0.56590.92580.07640.5045944368538070.02373
9rs99254823777897AG0.97751.02850.02820.4974363308926370.04764
9rs1329073923803667CG0.93670.93110.07190.4933596944334970.01592
9rs1179032823684329AC0.96870.97500.02560.4916049668669470.02577
9rs1328745623748914CG0.98431.06630.06740.4677553563734180.01552
9rs1330124223770286AG0.95640.93510.07040.4675004139053370.01166
9rs1096602123675144CT0.76810.97340.02840.4653394241715560.32671
9rs1690773123778214CT0.97120.97530.02640.4644527208233320.05034
9rs165308123780800CT0.99010.95920.04390.4636941276489660.03139
9rs379359023772688CT0.95941.06880.07030.4635678241779870.01552
9rs379358923772685AG0.95740.93630.07030.45655281991830.01552
9rs785981923685179CT0.97600.97660.02540.4539511335982660.00868
9rs379358823768312CT0.96221.06530.07000.4359260210228530.01552
9rs78356223813399AG0.89190.97740.02540.4337982811450870.00338
9rs147376523745232AG0.95121.06390.06900.4330913447731970.01552
9rs1096606423737517CG0.86060.96380.04140.4281747509591710.05144
9rs379358723768084CG0.96360.94010.07000.4233131947990040.01552
9rs379358423763141GT0.96510.94050.06990.420216403383190.01552
9rs379358523763473AG0.96520.94050.06990.4201021303968960.01552
9rs379358323763013AG0.96560.94070.06990.4180503416266820.01552
9rs1329407323758764CG0.96520.94430.06990.3851027839668650.00399
9rs1690761823688649GT1.00381.02080.02540.3786159715183470.03195
9rs289118823746299CT0.99900.97030.03830.3656235059116320.04505
9rs143130423758971AT0.98721.03040.03900.3534982499683880.04505
9rs497789223806554GT0.91301.02410.03170.3439976793170430.00392
9rs1690768523730241CT0.98720.96200.05210.3399887787106690.02325
9rs1011977323726400AG0.84041.01870.02550.3286419965565080.03187
9rs1755117423807548AG0.97771.02340.03260.3204812563042110.00196
9rs379359323800059AC0.17420.82280.27930.3143478158844760.00377
9rs1205707123749368AC0.99301.02650.03830.3053948010664310.04505
9rs969649923681051CG0.52331.04390.06330.3037310032544670.00224
9rs1096609323822717CT0.86990.97730.03510.2905604258675890.06556
9rs379357723727627AG0.84321.01620.02550.2776129058228760.03187
9rs202603723752529CT0.98940.98050.03150.2737619531973620.01914
9rs379360523814841GT0.85110.98040.03220.2684918164039750.00776
9rs1690767023726992CT0.75530.96890.05320.2575105354182250.0139
9rs136022423703125CG0.94910.98420.02790.2459576132145640.13376
9rs188790123692543AC0.88981.06620.11390.2413151501175590.02423
9rs785465423696338GT1.00311.01520.02920.2187474057515440.10273
9rs784798923708363CT0.99830.98540.02920.2112661411722920.10863
9rs1748182223696960CT0.99961.01470.02920.2099964796095110.10698
9rs1179122123708620GT0.91611.01570.03120.2095037230328900.09696
9rs141084123673174CT0.15661.06310.12260.2090115249111840.02404
9rs89164923671621AT0.83871.06110.12060.2056513961039170.00288
9rs102370423694310GT0.94420.98760.02550.204537105609620.12245
9rs702422423769696CT0.97181.01890.03840.2037032599482080.04895
9rs71771923721563AC0.99281.01350.02910.1907770783105780.00079
9rs379357823728335CT0.97350.97660.05220.1868194674139880.02325
9rs1234723223716069AG0.88430.97710.05130.1866191932661440.02754
9rs382908723703214CG0.99850.98700.02920.1842894602110370.10698
9rs1096608123773743AG0.82341.01840.04130.1810486883598270.05071
9rs1096609623825746AT0.87540.98770.02830.179864248129570.07962
9rs1096603523701955CG0.99990.98730.02920.1792076189117960.10698
9rs93288323676123AC0.79881.01210.02800.1755487299633870.00862
9rs1179055523693152CT0.99950.98780.02920.1715979215084070.10698
9rs1690771023756896AG0.98850.97680.05570.1714045436282980.01578
9rs785516823819684CT0.99210.98990.02420.1699248335702500.0553
9rs78345423822931GT0.89381.01030.02490.1675549588258890.07313
9rs1096609523825264CG0.90221.01150.02810.1646265475299910.07677
9rs785516123819702AG0.99180.99020.02420.1641826457065270.05522
9rs969506323823938AT0.90250.98870.02810.1638025192210750.07836
9rs969506223823909CT0.90260.98870.02810.1634860011093290.06728
9rs1096609023819865CT0.99380.99030.02420.1633594584272260.05801
9rs382908923703724AC0.99760.98830.02920.1631064836235660.10698
9rs238329423826062AG0.90151.01140.02810.1627272974977000.07836
9rs1748484123796012CG0.99650.98790.03080.1588909155318460.04033
9rs1096605623727227AG0.95011.01160.02930.1588283055004680.00524
9rs787072823819728GT0.99261.00940.02420.1562068016740870.05522
9rs382909023728298AG0.99370.98900.02900.1526124489726050.00079
9rs1075744723720654CT0.96151.01110.02900.1522423116076690.00466
9rs70222323803840AC0.97060.99080.02450.1516876963727160.00467
9rs185444223689886AG1.00480.98910.02910.1511337885052210.10698
9rs1690777923791446CT0.98990.98880.03010.1498440775779080.0548
9rs277104623800888AC0.99640.98920.02940.1482525808667360.05963
9rs132904023705135CT0.98171.01030.02780.1475810070629990.13152
9rs289118923751274AG0.95090.99030.02650.1466060225493340.08276
9rs1081197423822176CT0.91541.01020.02790.1447838052666370.07836
9rs1755779623820403AG0.99360.99130.02420.1437545992099460.05522
9rs379360223803023CT1.00240.98980.02930.1397219002477650.05963
9rs1690765823720232CT0.96130.98200.05290.1363797797296840.02325
9rs1223619523741700CT0.94311.01000.02950.1338899601556230.06959
9rs414214923821141AC0.97380.99190.02440.1325325121409490.06143
9rs183123423787302AG0.88161.01790.05520.1265050177438310.02308
9rs381859923720792CT0.96340.98350.05290.1229743841327510.02325
9rs1755061723795555CT0.99560.99040.03080.1221681085071060.06725
9rs1049181623707134AG1.00250.99100.02920.1213633269734830.10698
9rs379360323803100AG0.99851.00940.03080.1187294960706420.04033
9rs1268555223782601CT0.99701.00900.03000.116792966647610.05556
9rs379359423800167AC0.99650.99100.03080.1135656803710620.04033
9rs379359523801127AC0.92040.99130.03040.1122139651616280.04528
9rs1081196323720783AT0.91831.00830.02940.1093554637047520.00751
9rs379359923801669AG0.99581.00830.03080.1025378619869370.04033
9rs1096601723671867AG0.78611.00760.02930.098487190870060.07236
9rs204315323679584AC0.75320.96970.12570.0935033402006470.00352
9rs132902923675661CT0.83300.99310.02840.09334178232840020.09995
9rs81068123789239AT0.96910.99340.02770.09039048950983110.05058
9rs1690778823798910AG0.99640.99300.03080.0868752096104410.02429
9rs1081197323821902AG0.88331.00630.02860.08307253388700730.06263
9rs647575723805155CG0.96100.99320.03110.08301995267961780.04142
9rs1096602023674909GT0.82100.99400.02840.07966792846041070.08572
9rs497788723708520GT0.87841.00520.02490.07810552907089770.017
9rs379360123801903GT0.99651.00520.03080.06263258248271040.03893
9rs71771823721597AT0.97610.99550.02680.06238182060617650.01034
9rs70221723782674CT0.96051.00900.05370.06158035420680690.02358
9rs1081197623823710CT0.78231.00620.03740.06113017848701330.02874
9rs1096608723806941CT0.98780.99520.02990.0597326085539880.0548
9rs1096605923730030AC0.95771.00440.02700.05963295401433480.00098
9rs141084623778680CT0.97691.00400.02590.05606053552778360.05553
9rs379359123773162CT0.77281.00540.03920.05012229596312520.03226
9rs379359723801315AG0.48560.98640.10430.04793440981494970.00163
9rs1073339223684188CT1.00700.99670.02640.04619200233469280.11484
9rs1096604723718276AC0.88260.99670.02760.04421607108308860.00276
9rs132904123710904CT0.98120.99680.02670.04282386959515380.01034
9rs1081196223718372AG0.88210.99690.02760.04148389657695890.00049
9rs1081196523731278CT0.99580.99720.02690.03748860649240310.00463
9rs497788623679717AC0.87061.00280.02760.03711001260820880.08728
9rs219573123775967AC0.96720.99560.05370.02946717023167570.02308
9rs1096604623716194CG0.98201.00200.02670.02617967564731640.01034
9rs70221623782084AC0.96410.99610.05350.02599520310258540.02308
9rs185444323689733AG0.99551.00200.02850.02493600390476390.1129
9rs1096604523714832CT0.98050.99820.02670.02383349986802480.0085
9rs132903723774889CT0.84200.99820.02910.02163685291611710.06644
9rs1096609423823417AT0.82340.99850.03560.01479814163542820.03565
9rs497788923776433AG0.96191.00200.05370.01282549891245830.02308
9rs647575623804973CG0.82401.00110.03220.01233373507372540.06661
9rs211622723677455AG0.77240.99890.03200.01206573476784140.0725
9rs786164623722000CT1.01431.00080.02640.01059468199848400.01034
9rs1096606123730210AC1.00431.00070.02660.009128595198514030.01034
9rs497789023776488CT0.96481.00090.05370.006123085058788790.02308
9rs219573223775979CT0.96310.99980.05380.001087095641214160.02308
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.